专利检索 ipc:"C07D409/00" 第 4 页

31.

发明专利
失效

公开(公告)号：JP2002504067A

公开(公告)日：2002-02-05

申请号：JP53033696

申请日：1996-03-25

IPC分类号： A61K38/00 , A61K31/40 , A61K31/41 , A61K31/47 , A61P9/00 , A61P9/10 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D403/00 , C07D403/12 , C07D409/00 , C07D417/00 , C07K5/02 , C07K5/06 , C07K5/078

32.

发明专利
COMPOUND HAVING GROWTH HORMONE-RELEASING CHARACTERISTICS 失效

公开(公告)号：JP2000143613A

公开(公告)日：2000-05-26

申请号：JP32892999

申请日：1999-11-19

申请人： NOVO NORDISK AS

发明人： HANSEN THOMAS KRUSE , PESCHKE BERND , LAU JESPER , LUNDT BEHREND FRIEDRICH , ANKERSEN MICHAEL , WATSON BRETT , MADSEN KJELD

IPC分类号： C07D333/20 , A61K31/00 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/454 , A61K38/00 , A61K38/07 , A61K38/08 , A61P3/00 , A61P5/00 , A61P5/06 , A61P5/10 , A61P15/00 , A61P15/14 , A61P19/00 , B41J19/20 , C07C237/00 , C07C237/22 , C07C311/05 , C07C335/14 , C07D213/12 , C07D227/00 , C07D271/06 , C07D333/00 , C07D333/24 , C07D333/60 , C07D409/00 , C07D413/12 , C07K5/03 , C07K5/06 , C07K5/065 , C07K5/078 , C07K5/10 , C07K7/02 , C07K14/60

摘要： PROBLEM TO BE SOLVED: To obtain a compound having growth hormone-releasing characteristics, having a more excellent property than that of a conventional compound and having an analogous property to a peptide. SOLUTION: This compound is expressed by formula I wherein, R1 and R2 are each H or a (aryl-substituted) (1-6C) alkyl; (a) and (b) are each 1 or 2; G is H, O-(CH2)k-R27 (wherein, R27 is H, a halogen or the like; (k) is 0-2) or the like; J is expressed by formula II (wherein, R32-R36 are each H, a halogen or the like) or the like; E is CONR12R13 [wherein, R12 and R13 are each H, a (substituted) (1-6C) alkyl or the like]; D is expressed by formula III [wherein, R3-R6 are each H, a (substituted) (1-6C) alkyl or the like; (n) is 0-3] or the like} and is e.g. (2E)-5-amino-5-methylhexa-2-enoic acid N-methyl-N-((1R)-1-(N- methyl-N-((1R-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphth yl)ethyl) amide. The compound of formula I is synthesized e.g. through dropping ethyl chloroformate into a solution of both 3-t-butoxycarbonylamino-3-methylbutanoic acid and triethylamine as a starting step.

33.

发明专利
失效

公开(公告)号：JPH11501327A

公开(公告)日：1999-02-02

申请号：JP51753197

申请日：1996-10-28

IPC分类号： A61K31/55 , A61K31/554 , A61P1/00 , A61P1/14 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P15/00 , A61P17/04 , A61P17/06 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D243/06 , C07D243/08 , C07D267/08 , C07D267/10 , C07D267/16 , C07D281/04 , C07D281/06 , C07D281/10 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D413/00 , C07D417/00 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04

34.

发明专利
PYRROLOINDOLE DERIVATIVE AND ITS PRODUCTION INTERMEDIATE 失效

公开(公告)号：JPH10265473A

公开(公告)日：1998-10-06

申请号：JP721198

申请日：1998-01-19

申请人： KYORIN SEIYAKU KK , SAGAMI CHEM RES

发明人： FUKUDA YASUMICHI , SHIMAZAWA RUMIKO , OMORI YASUO , TERAJIMA ATSURO

IPC分类号： C07D487/04 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P31/04 , A61P35/00 , C07D265/30 , C07D409/00 , C07F7/18

摘要： PROBLEM TO BE SOLVED: To obtain a new compound excellent in formation of activator in an organism, useful as a prodrug effective against solid tumor and having low toxicity. SOLUTION: This carbamoyloxy group-containing compound is shown by formula I [R is OH or pyrrolidinyl; (n) is 1 or 2; R is a 1-4C alkyl; X-Y or Y-X is CH2 , CHOH, CH2 -CH2 , etc.; Z is Cl or Br; Ar is a group of formula II (Z is O or NH; (m) is 0 or 1-4), etc.] such as (1S)-chloromethyl-5- [(2S) hydroxymethylpyrrolidin-1ylcarbonyl]oxy}-3-[5(7-methoxybenzofuran-2-yl carbonyl) amino1H-indol2-ylcarbonyl]-7trifluoromethyl-1,2,3,6-tetrahydropyrrolo[ 3,2- e]indole-8carboxylic acid methyl ester.

35.

发明专利
失效

公开(公告)号：JP2802437B2

公开(公告)日：1998-09-24

申请号：JP12771489

申请日：1989-05-19

IPC分类号： C07D207/12 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P23/00 , A61P25/04 , C07D207/26 , C07D211/76 , C07D405/00 , C07D409/00 , C07D409/06 , C07D413/06

36.

发明专利
失效

公开(公告)号：JP2656184B2

公开(公告)日：1997-09-24

申请号：JP1936392

申请日：1992-01-09

申请人： HEKISUTO MARION RUSERU INC

发明人： HEREN FUU ONGU , NIKORASU JEI RIBU , JOZEFU PERESU , JON JERAADO JURUKAKU

IPC分类号： A61K31/495 , A61P25/18 , C07D209/48 , C07D221/20 , C07D239/42 , C07D277/14 , C07D277/20 , C07D277/34 , C07D295/12 , C07D295/125 , C07D401/12 , C07D403/12 , C07D409/00 , C07D409/12 , C07D417/12 , C07D471/04

37.

发明专利
失效

公开(公告)号：JPH08502998A

公开(公告)日：1996-04-02

申请号：JP51325994

申请日：1993-11-18

IPC分类号： A01N43/54 , A01N43/78 , A01N43/84 , A01N47/18 , A01N47/20 , A01N55/00 , C07D239/00 , C07D401/00 , C07D409/00 , C07D413/00 , C07F7/08