公开(公告)号：JPH03275679A

公开(公告)日：1991-12-06

申请号：JP7617390

申请日：1990-03-26

申请人： TAISHO PHARMA CO LTD ,  NIPPON SUISAN KAISHA LTD

发明人： IWATA MICHIZOU ,  IMANISHI TAKESHI ,  SATO MASAKAZU ,  KAWASHIMA YUTAKA ,  GOTO JUN ,  CHIBA YOSHIYUKI ,  SATAKE MIKIO

IPC分类号： C07D277/04 ,  A61K31/425 ,  A61K31/426 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/08 ,  A61P25/28

摘要： NEW MATERIAL:A compound expressed by formula I [R is H, benzoyl or (substituted) phenyl sulfonyl; n is 0-3; X is H, halogen or lower alkoxy; R is expressed by formula II (R is H or lower alkyl) or expressed by formula III]. EXAMPLE:Ethyl 4-[(thiazolidine-2-yl)methyl]phenoxy acetate. USE:Used as an antagonist against thromboxane A2. Said compound has low toxicity and is useful for remedy of cerebrovascular twitch after subarachnoid hemorrhage and following cerebral ischemia symptom or asthma, etc. PREPARATION:An alcoholic substance expressed by formula IV is made to an aldehyde substance expressed by formula V by chromate oxidation with chromate anhydride, etc. Then, the aldehyde substance is reacted with cisthiamine hydrochloride in a solvent such as water or water-containing methanol to afford the compound expressed by formula I having H as the group R .

公开(公告)号：JPH0373546B2

公开(公告)日：1991-11-22

申请号：JP1135683

申请日：1983-01-28

申请人： UBE INDUSTRIES

发明人： IWATA FUMIO ,  HARADA KATSUMASA ,  SUGISE RYOJI

IPC分类号： C07D277/04 ,  C07D277/10 ,  C07D279/06 ,  C07D281/02 ,  C07D283/02

公开(公告)号：JPH03500886A

公开(公告)日：1991-02-28

申请号：JP50011789

申请日：1988-10-11

IPC分类号： C07D277/04 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K38/00 ,  A61P9/12 ,  C07C235/04 ,  C07C237/04 ,  C07C237/22 ,  C07C255/59 ,  C07C323/52 ,  C07C323/60 ,  C07D207/09 ,  C07D213/75 ,  C07D263/06 ,  C07D265/06 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

公开(公告)号：JPH01301671A

公开(公告)日：1989-12-05

申请号：JP13224388

申请日：1988-05-30

申请人： SUNTORY LTD

发明人： SAITO MASAYUKI ,  TANAKA TAKAHARU ,  HIGUCHI NAOKI ,  HASHIMOTO MASAKI ,  FUKAMI JIICHI

IPC分类号： C12N9/99 ,  A61K31/425 ,  A61K31/426 ,  A61P25/28 ,  A61P43/00 ,  C07D277/04 ,  C07D277/06 ,  C07D417/06

摘要： NEW MATERIAL:A thiazolidine derivative shown I [n is 2 or 3; X is S, CH2 or CH(OH); R is nonsubstituted, substituted phenyl or 5-20C which may contain unsaturated bond; Y is O, CO or CH2]. EXAMPLE:N-(4-Phenylbutanoyl)proline-thiazolidinamide. USE:A drug having excellent anti-prolylendopeptidase activity extremely useful as a drug for alleviating amnesia. PREPARATION:A compound shown by formula II is condensed with a compound shown by formula III (R' is methyl or ethyl) in a solvent not to participate in the reaction in the presence of a condensation reagent to give a compound shown by formula IV. Then this compound is hydrolyzed with an alkali by a conventional procedure to give a carboxylic acid, which is condensed again with thiazolidine in a solvent not to participate in the reaction in the presence of a condensation agent to give a compound shown by formula I.

公开(公告)号：JPH01199941A

公开(公告)日：1989-08-11

申请号：JP31363588

申请日：1988-12-12

申请人： BASF AG

发明人： ANDOREASU HOOMAN ,  UORUFUGANGU ROITAA ,  RORUFU FUIIKENCHIYAA ,  TEO PURORU

IPC分类号： C07D277/04 ,  C07C319/02 ,  C07C319/06 ,  C07C323/25 ,  C07C323/58 ,  C07D277/60

公开(公告)号：JPS646263A

公开(公告)日：1989-01-10

申请号：JP3867588

申请日：1988-02-23

申请人： ONO PHARMACEUTICAL CO

发明人： TODA MASAAKI ,  OUCHIDA SHUICHI ,  ONO HIROYUKI

IPC分类号： C12N9/99 ,  A61K31/425 ,  A61K31/426 ,  A61K31/445 ,  A61K31/47 ,  A61K31/505 ,  A61P25/28 ,  A61P43/00 ,  C07D277/04 ,  C07D277/06 ,  C07D417/06

摘要： NEW MATERIAL:The thiazolidine derivative of formula I [R is G-E-D-B-A-; A and B are single bond or 1-6C alkylene, A may be 2-6C alkenylene or group of formula II-III; Y is 1-4C alkylene or 2-4C alkenylene; D is single bond, O, CO or group of formula IV-V; R is H, 1-4C alkyl, phenyl or benzyl; E is single bond or 1-8C alkylene which may have substituent (phenyl or ben zyl); G is carbon ring or heterocyclic group which may have 1-3 substituents (1-6C alkyl, halogen, CF3 or NO2); A and B are not single bond at the same time]. EXAMPLE:4(R)-3-[3-[N-(4-methylbenzyl)carbamoyl]propionyl]thiazolidin-4 -al. USE:A prolylendopeptitase inhibitor useful as an antiamnestic agent. PREPARATION:The compound of formula I can be produced by oxidizing a compound of formula VI [R is G-E-D -B-A-; D is D or CH(OH)] under mild condition.

公开(公告)号：JPS63277642A

公开(公告)日：1988-11-15

申请号：JP8802988

申请日：1988-04-08

申请人： LILLY CO ELI

发明人： ROBAATO DEIREIN DEIRAADO ,  DORISU ERUFURETSUDO MATSUKARUR ,  FURANSHISU PATORITSUKU KAARU

IPC分类号： C07D277/04 ,  A61K31/12 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/38 ,  A61K31/382 ,  A61K31/41 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61P11/00 ,  A61P37/08 ,  A61P43/00 ,  C07C49/00 ,  C07C51/00 ,  C07C51/08 ,  C07C51/347 ,  C07C53/132 ,  C07C59/125 ,  C07C59/64 ,  C07C59/90 ,  C07C67/00 ,  C07C69/732 ,  C07C69/738 ,  C07C201/00 ,  C07C205/45 ,  C07C213/00 ,  C07C225/22 ,  C07C229/42 ,  C07C229/44 ,  C07C253/00 ,  C07C255/15 ,  C07C255/33 ,  C07C257/04 ,  C07C313/00 ,  C07C317/24 ,  C07C317/28 ,  C07C317/44 ,  C07C317/46 ,  C07C317/48 ,  C07C323/18 ,  C07C323/19 ,  C07C323/22 ,  C07C323/29 ,  C07C323/62 ,  C07D257/04 ,  C07D285/10 ,  C07D335/00 ,  C07D417/04

公开(公告)号：JPS6354712B2

公开(公告)日：1988-10-28

申请号：JP15813079

申请日：1979-12-07

申请人： SOGO YATSUKO KK

发明人： OOSAWA YASUKO ,  UCHIKUGA SABURO

IPC分类号： C07D277/04 ,  C07D277/60

公开(公告)号：JPS63203672A

公开(公告)日：1988-08-23

申请号：JP3570587

申请日：1987-02-20

申请人： KOWA CO

发明人： KYOTANI YOSHINORI ,  YAMAGUCHI TAKASHI ,  ISHIHAMA HIROSHI ,  OTA TOMIO

IPC分类号： C07D513/04 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/495 ,  A61K31/535 ,  A61P1/04 ,  A61P1/16 ,  C07D277/04 ,  C07D277/18 ,  C07D277/20 ,  C07D277/38 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/50 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12

摘要： NEW MATERIAL:The compound of formula I {R1 and R2 are H, alkyl, alkoxy, phenyl, etc., or together form group of formula II (R3 is alkyl, alkoxy, acyl, phenyl, etc.; n is 0-4); A is group of formula III or formula IV [R4-R7 are H, CN or B-R8 (B is Alk, CO, Alk-CO, SO2, Alk-SO2, etc.; Al is alkylene or alkenylene; R8 is H, halogen, amino, aryl, etc.)]}. EXAMPLE:3-Methyl-2-cyanoiminobenzothiazoline. USE:An antiulcer agent and a remedy for hepatopathy. PREPARATION:For example, a compound of formula VII can be produced by reacting a compound of formula V with a dimethyl cyanamidothiocarbonate of formula VI.

公开(公告)号：JPS6330901B2

公开(公告)日：1988-06-21

申请号：JP14882279

申请日：1979-11-19

申请人： NISSHIN FLOUR MILLING CO

发明人： TAWARA YOSHUKI ,  KOYAMA HIROYASU ,  KOMATSU YASUHIRO ,  KUBOTA REIKO ,  TAKAHASHI TOSHIHIRO

IPC分类号： C07D295/02 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07D231/12 ,  C07D233/58 ,  C07D277/04 ,  C07D295/03 ,  C07D521/00