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公开(公告)号:JPH11181318A
公开(公告)日:1999-07-06
申请号:JP35789697
申请日:1997-12-25
申请人: SUMITOMO CHEMICAL CO
IPC分类号: C07D333/42 , C09B29/26 , C09B67/48 , D06P1/18 , D06P3/54
摘要: PROBLEM TO BE SOLVED: To obtain a disperse dye which effects a satisfactory dying even under a severe condition at a high temperature by employing a crystalline monoazo disperse dye in which a certain peak appears in an X-ray diffraction analysis with Cu-Kα ray. SOLUTION: This is a crystalline monoazo disperse dye in which a strong peak appears at a 2θ of 5.3-in the diffraction angle 2 θ range of 5 deg.-30 deg.. In this dye, weak peaks also appear at 9.2-,12.9-, 16.0-, 16.3-, 17.6-, 18.8- and 21.1-. A monoazo disperse dye having such a crystalline form is obtained by, directly or after a neutralization at pH 6-7, agitating a reaction mass for a typical monoazo dye at a temp. of 50-130 deg.C for 0.5-30 hr. Alternatively, the monoazo disperse dye is obtained by dispersing a cake which is a filtered solid compound separated from a reaction mass into an aqueous medium of pH 7.5-12.0 and agitating it at a temp. of 60-130 deg.C for 0.5-30 hr.
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公开(公告)号:JPH10120631A
公开(公告)日:1998-05-12
申请号:JP15856397
申请日:1997-06-16
申请人: LILLY CO ELI
发明人: HAHN PATRIC JAMES , KALDOR STEPHEN WARREN , SIEGEL MILES GOODMAN , DRESSMAN BRUCE ANTHONY , FRITZ JAMES ERWIN
IPC分类号: G01N33/15 , B01J19/00 , B01L3/00 , C07B61/00 , C07C209/00 , C07C211/03 , C07D207/08 , C07D209/42 , C07D209/88 , C07D211/60 , C07D213/38 , C07D213/50 , C07D215/18 , C07D241/20 , C07D249/18 , C07D265/30 , C07D277/04 , C07D295/08 , C07D295/18 , C07D303/02 , C07D307/46 , C07D307/52 , C07D317/28 , C07D319/12 , C07D333/22 , C07D333/28 , C07D333/42 , C07D405/12 , C40B60/14
摘要: PROBLEM TO BE SOLVED: To obtain the subject compound useful for discovering a new lead compound for developing medicines by a combined reaction in a liquid phase. SOLUTION: This combined reductive amination reaction process by using a scavenger comprises producing a library of a compound having a tertiary amine skeleton containing three reversible substituent groups. Each library compound is shown by formula I (R1 , R2 and R3 are each a nonobstructive substituent group) and is obtained by adding an aldehyde of the formula R3 CHO to a reaction region containing a liquid medium, then adding a secondary amine reagent of formula II to the reaction region, then maintaining the reaction system at a temperature for a time to enable the reductive amination of the compound of formula II, adding an amine reactive scavenger of formula III (P is an insoluble solid support; L is a bondable group; (ARS) is an amine reactive substituent group), maintaining the reaction system at a temperature for a time to react the amine reagent with the scavenger, separating the solid support scavenger and recovering the tertiary amine library compound. The reaction is carried out generally at -10 deg.C to 60 deg.C under normal pressure.
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公开(公告)号:JPH09504787A
公开(公告)日:1997-05-13
申请号:JP50895194
申请日:1994-09-05
IPC分类号: C07D233/54 , A61K31/341 , A61K31/345 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/428 , A61P9/06 , C07C217/84 , C07D235/04 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/32 , C07D277/56 , C07D277/64 , C07D277/68 , C07D307/71 , C07D307/73 , C07D333/42 , C07D521/00
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公开(公告)号:JPH07258247A
公开(公告)日:1995-10-09
申请号:JP5071694
申请日:1994-03-22
申请人: KIRIN BREWERY
发明人: TANAKA YOSHIHIRO , NAKAJIMA TATSUO
IPC分类号: C07D333/42 , A61K31/38 , A61K31/381 , A61P11/00 , A61P11/08
摘要: PURPOSE:To provide the novel compound having an action to more specifically relax bronchial smooth muscles than vascular smooth muscles, and useful as an antiasthmatic medicine capable of dilating bronchial tubes without being accompanied by the lowering in blood pressure. CONSTITUTION:This compound is N-Cyano-N'-(2-nitroethyl)-2-(5-nitrothiophene) carboximidamide of formula I. The compound is obtained by treating 2-cyano-5- nitrothiophene of formula II with hydrogen chloride gas in a propanol solution, reacting the obtained propyl=2-(5-nitrothiophene)carboximidate with cyanamide in a buffer solution preferably comprising a phosphoric acid solution, and subsequently reacting the obtained propyl=N-cyano-2-(5-nitrothiophene)carboximidate of formula III with 2-nitroxyethylamine.
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公开(公告)号:JPH07173151A
公开(公告)日:1995-07-11
申请号:JP33882793
申请日:1993-12-01
申请人: KANEBO LTD
IPC分类号: G03C5/56 , C07D333/12 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/38 , C07D333/42 , C07D409/06 , C07D417/06 , C07D495/04 , C09K9/02 , G11B7/00 , G11B7/004 , G11B7/0055 , G11B7/24 , G11B7/244
摘要: PURPOSE:To provide a new compound having a photochromic property excellent in thermal stability, repetition durability, semiconductor laser susceptibility and sensitivity, etc., of its colored state and suitable for an optical recording material, etc. CONSTITUTION:A compound having a structure of formula I (n is an integer of 2 to 5; l and m are each an integer of 0, l or 2; R and R are each an alkyl; R and R are each H, an alkyl, a dialkylamino, cyano, nitro or an alkoxy; A and B are each an aromatic or a heterocycle), e.g. 1,2-bis[5-(4- methoxyphenyl)-2,4-dimethyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene of formula II. This compound can be obtained, e.g. by synthesizing 3-iodo-5(4- methoxyphenyl)-2,4-dimethylthiophene of formula III from p-iodoanisole, etc., as the raw materials, adding tetrahydrofuran (THF) thereto, cooling it, subsequently adding an n-butyllithiumhexane solution dropwise thereto, then adding a THF solution of perfluorocyclopentene dropwise thereto, subsequently adding water and extracting it with ethyl acetate.
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公开(公告)号:JPH0421677A
公开(公告)日:1992-01-24
申请号:JP12310790
申请日:1990-05-15
申请人: TOKUYAMA SODA KK
发明人: KITAJIMA TOSHIO , KATO SHOZO
IPC分类号: C07D333/42 , A01N43/10
摘要: NEW MATERIAL:A compound of formula I [X1 and X2 are each H, halogen, formyl, NO2, CN, alkoxy, alkylthio, (substituted)alkyl, etc.; X3 and X4 are each H, halogen or (substituted)alkyl; R is H, (substituted)alkyl or (substituted)phenyl; Y is NR R (R and R are each H, alkyl, alkenyl, etc.) or OR (R is H or alkyl)]. EXAMPLE:2-[p-(2-Nitro-3-thienyloxy)phenoxy]ethyl butyrate. USE:A bactericide/fungicide. PREPARATION:For example, the objective compound of the formula I can be obtained by a reaction, in the presence or absence of a solvent (e.g. benzene, toluene, xylene), between (A) a halogenothiophene compound of formula II (X5 is halogen) and (B) a phenol derivative of formula III (M is H or alkali metal).
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公开(公告)号:JPH03261780A
公开(公告)日:1991-11-21
申请号:JP5950190
申请日:1990-03-09
发明人: TOMIYAMA TAKESHI , TOMIYAMA ITARU , WAKABAYASHI SHUICHI , MOCHIZUKI SEIICHIRO , FUTAMURA MASAYUKI , ICHIKAWA SENJU
IPC分类号: C07D333/42 , A61K31/38 , A61K31/381 , A61P9/06
摘要: NEW MATERIAL:A compound of formula I [R1, R2 are H, lower alkyl (excluding a case of R1=R2=H); R3, R4 are lower alkyl; m, n are 0-2 and mnot equal to n]. EXAMPLE:N-[(2-Diethylamino-1-methyl)ethyl]-4-nitrothiophene carboxamide.hydrochloride. USE:An antiarrhythmic agent. PREPARATION:A compound of formula II (X is halogen) is reacted with a compound of formula III preferably in the presence of a base (e.g. an alkali metal hydroxide or an amine) in a solvent such as water or acetone.
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公开(公告)号:JPH03218342A
公开(公告)日:1991-09-25
申请号:JP30727290
申请日:1990-11-15
发明人: SHIMADA YASUHIRO , SATO KOZO
IPC分类号: G03C7/32 , C07C255/23 , C07C255/24 , C07C255/34 , C07C255/35 , C07C255/41 , C07C255/44 , C07C255/47 , C07C317/44 , C07D213/57 , C07D213/64 , C07D213/84 , C07D215/48 , C07D233/72 , C07D233/90 , C07D239/36 , C07D249/10 , C07D249/12 , C07D249/18 , C07D249/20 , C07D275/04 , C07D277/20 , C07D277/30 , C07D277/56 , C07D333/38 , C07D333/42 , C07D417/06 , C07D487/04 , C07D521/00 , G03C7/413
摘要: NEW MATERIAL:A compound expressed by formula I (W is H or eliminating group which causes elimination when oxide of aromatic primary amine derivative is subjected to coupling reaction; R1 is substituent group; V is N or CR3; When V is N, R2 is substituent group and when V is CR3, at least one of R2 and R3 is electron attracting substituent group and the other is substituent group, provided that when R2 or R3 is aliphatic group or aromatic group, the other is not acyl; R1 and R2 together may form a ring). EXAMPLE:A compound expressed by formula II. USE:Cyan coupler for photograph capable of providing cyan color image reduced in subsidiary absorption and having good duplicativity and excellent fastness. PREPARATION:For example, 3-nitrobensonitrile is allowed to heat with acetonitrile in the presence of potassium tert.-butoxide to give a compound expressed by formula III, which is then made to with malononitrile and the resultant compound expressed by formula IV is reduced with iron and then subjected to a reaction with a compound expressed by formula V to provide the exemplified compound.
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公开(公告)号:JPH02142783A
公开(公告)日:1990-05-31
申请号:JP20148989
申请日:1989-08-04
申请人: BASF AG
发明人: RAINAA KOBAA , YOOAHIMU REIENDETSUKAA , RAINAA ZEERE , KURAUSU FUITSUSHIYAA , HANSU TEEOBARUTO , BURUUNO BUYURUTSUAA , KAARUUOTSUTOO BUESUTOFUAREN , NORUBERUTO MAIYAA
IPC分类号: A01N43/10 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/52 , A01N43/74 , A01N43/80 , C07D333/08 , C07D333/16 , C07D333/18 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/42 , C07D333/44 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号:JPS6429373A
公开(公告)日:1989-01-31
申请号:JP16608388
申请日:1988-07-05
申请人: SHELL INT RESEARCH
IPC分类号: C07D333/36 , C07D333/38 , C07D333/42
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