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    New peptide
    2.
    发明专利
    New peptide 审中-公开
    新肽

    公开(公告)号：JP2009184984A

    公开(公告)日：2009-08-20

    申请号：JP2008028093

    申请日：2008-02-07

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： HAYASHI YUYA ,  TAKIGUCHI KUMIKO ,  TAKAGI KYOKO ,  HONMA YOICHI

    IPC: C07K5/103 ,  A23L1/305 ,  A61K8/64 ,  A61K38/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08

    Abstract: PROBLEM TO BE SOLVED: To provide a new peptide having a specific amino acid sequence having the safe and significant promotion capacity of collagen production, its derivative or their salts. SOLUTION: This new peptide having the specific amino acid sequence and expressed by formula (1): Leu-Arg-Xaa-Asn [wherein, Xaa is expressed by any of His, Lys or Arg] is found to be utilized as a new material having the safe and significant promotion capacity of the collagen production. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供具有特异性氨基酸序列的新肽，其具有胶原蛋白生产的安全和显着的促进能力，其衍生物或其盐。 解决方案：发现具有特定氨基酸序列并由式（1）表达的新肽：Leu-Arg-Xaa-Asn [其中，Xaa由任何His，Lys或Arg表达]用作 一种具有安全而显着促进胶原蛋白生产能力的新材料。 版权所有（C）2009，JPO＆INPIT

    Aquaporin expression promoter
    3.
    发明专利
    Aquaporin expression promoter 审中-公开
    AQUAPORIN表达促进剂

    公开(公告)号：JP2006290873A

    公开(公告)日：2006-10-26

    申请号：JP2006058780

    申请日：2006-03-05

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： HONMA YOICHI

    IPC: A61K31/355 ,  A61P17/00 ,  A61P17/16 ,  A61P43/00 ,  C07D311/72

    Abstract: PROBLEM TO BE SOLVED: To provide an aquaporin expression promoter in skin cells and to provide an improving agent for the skin cell environment promoting expression of a hyaluronic acid synthase, promoting the expression of the aquaporin in the skin cells and maintaining the state of the whole environment of the skin cells healthy.
    SOLUTION: The aquaporin expression promoter comprising a tocopheryl retinoate as an active ingredient is provided. The aquaporin expression promoter having excellent humectant effects on the aqueous environment of the skin cells by promoting the expression of the aquaporin is provided. Since the expression of the aquaporin is promoted by increasing the expression of the hyaluronic acid synthase, remarkably increasing the amount of the synthesized hyaluronic acid and simultaneously promoting the expression of the aquaporin using the tocopheryl retinoate as the active ingredient, the excellent improving agent for the skin cell environment preparing the suitable whole environment of the skin cells containing intercellular spaces and maintaining the cells healthy is provided.
    COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供皮肤细胞中的水通道蛋白表达启动子，并提供促进透明质酸合酶表达的皮肤细胞环境的改善剂，促进水通道蛋白在皮肤细胞中的表达并保持状态 的整个环境的皮肤细胞健康。 提供了包含生育酚维甲酸酯作为活性成分的水通道蛋白表达启动子。 提供了通过促进水通道蛋白酶的表达，对皮肤细胞的水性环境具有优异的保湿作用的水通道蛋白表达启动子。 由于通过增加透明质酸合酶的表达来促进水通道蛋白的表达，因此显着增加合成的透明质酸的量，同时通过维生素A维生素A作为活性成分促进水通道蛋白酶的表达， 提供了制备包含细胞间隙并维持细胞健康的皮肤细胞的合适的整个环境的皮肤细胞环境。 版权所有（C）2007，JPO＆INPIT

    External preparation for skin
    4.
    发明专利
    External preparation for skin 审中-公开
    外用皮肤制剂

    公开(公告)号：JP2006213696A

    公开(公告)日：2006-08-17

    申请号：JP2005071146

    申请日：2005-03-14

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： HARADA AYAKO ,  HONMA YOICHI ,  ABE MASAMICHI

    IPC: A61K8/00 ,  A61K8/30 ,  A61K8/49 ,  A61K8/67 ,  A61K31/07 ,  A61K31/375 ,  A61K31/522 ,  A61K47/10 ,  A61K47/24 ,  A61P17/02 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide an external preparation for the skin, excellent in percutaneous absorption of vitamin As, specific vitamin Cs and xanthine derivatives.
    SOLUTION: The external preparation for the skin, excellent in percutaneous absorption of the vitamin As, the specific vitamin Cs and the xanthine derivatives contains a phospholipid and a glycol ether. As a result, the efficient penetration of the vitamin As, the specific vitamin Cs and the xanthine derivatives to the skin is expected.
    COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供皮肤的外用制剂，维生素As，特定维生素Cs和黄嘌呤衍生物的经皮吸收性优异。

    解决方案：外用皮肤制剂，经皮吸收维生素As，特定维生素Cs和黄嘌呤衍生物含有磷脂和二醇醚。 因此，预期将维生素As，特定的维生素C 3和黄嘌呤衍生物有效渗入皮肤。 版权所有（C）2006，JPO＆NCIPI

    Elastin production promoter
    5.
    发明专利
    Elastin production promoter 审中-公开
    ELASTIN生产促销商

    公开(公告)号：JP2008074788A

    公开(公告)日：2008-04-03

    申请号：JP2006257445

    申请日：2006-09-22

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： TAKIGUCHI KUMIKO ,  HONMA YOICHI ,  KIKUCHI KAZUAKI ,  TSUNETSUGU SHUICHI

    IPC: A61K8/64 ,  A61K38/00 ,  A61K45/00 ,  A61P17/16 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/08 ,  C07K5/103 ,  C07K7/06

    CPC classification number: C07K5/101 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/08

    Abstract: PROBLEM TO BE SOLVED: To provide a useful new elastin production promoter having remarkable elastin production-promoting ability.
    SOLUTION: The elastin production promoter includes at least one component selected from the group consisting of the peptide having an amino acid sequence represented by the formula I: Leu-Glu-His-Ala, derivatives thereof and salts thereof. Another version of the elastin production promoter includes at least one component selected from the group consisting of peptides having an amino acid sequence wherein one or more amino acids are conservatively substituted, deleted and/or added in the amino acid sequence of the formula I and having elastin production-promoting ability in cells, derivative thereof and salt thereof.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供具有显着的弹性蛋白生产促进能力的有用的新的弹性蛋白生产促进剂。 解决方案：弹性蛋白生产促进剂包括至少一种选自具有由式I表示的氨基酸序列的肽的组分：Leu-Glu-His-Ala，其衍生物及其盐。 弹性蛋白生产促进剂的另一版本包括至少一种选自具有氨基酸序列的肽的组分，其中一个或多个氨基酸在式I的氨基酸序列中被保守取代，缺失和/或添加并具有 细胞中的弹性蛋白生产促进能力，其衍生物及其盐。 版权所有（C）2008，JPO＆INPIT

    Skin care preparation
    8.
    发明专利
    Skin care preparation 审中-公开
    皮肤护理准备

    公开(公告)号：JP2007045808A

    公开(公告)日：2007-02-22

    申请号：JP2005369975

    申请日：2005-12-22

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： HARADA AYAKO ,  HONMA YOICHI ,  ABE MASAMICHI

    IPC: A61K47/08 ,  A61K8/33 ,  A61K8/55 ,  A61K9/06 ,  A61K47/24 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide a skin care preparation excellent in percutaneous absorption of an active constituent. SOLUTION: The skin care preparation comprises a composition comprising a phospholipid, and ≥22 wt.%. of one kind or two kinds or more of glycol ethers selected from a group comprising ethylene glycol monoether, ethylene glycol diether, propylene glycol monoether, propylene glycol diether, butylene glycol monoether, butylene glycol diether, diethylene glycol monoether, diethylene glycol diether, dipropylene glycol monoether, dipropylene glycol diether, dibutylene glycol monoether and dibutylene glycol diether. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 待解决的问题：提供优异的活性成分的经皮吸收的护肤制剂。 皮肤护理制剂包含含有磷脂的组合物，≥22重量％。 选自乙二醇单醚，乙二醇二醚，丙二醇单醚，丙二醇二醚，丁二醇单醚，丁二醇二醚，二甘醇单醚，二甘醇二醚，二丙二醇的一种或两种以上的二醇醚 单醚，二丙二醇二醚，二丁二醇单醚和二丁二醇二醚。 版权所有（C）2007，JPO＆INPIT

    Composition having collagen production-accelerating function
    9.
    发明专利
    Composition having collagen production-accelerating function 有权
    具有胶原生产加速功能的组合物

    公开(公告)号：JP2008001661A

    公开(公告)日：2008-01-10

    申请号：JP2006174622

    申请日：2006-06-23

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： TAKIGUCHI KUMIKO ,  HONMA YOICHI ,  KIKUCHI KAZUAKI ,  TSUNETSUGU SHUICHI

    IPC: A61K38/00 ,  A61K8/49 ,  A61K8/64 ,  A61K31/375 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00 ,  A61Q19/00 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08

    CPC classification number: C07K5/101 ,  A61K8/64 ,  A61K8/671 ,  A61K38/07 ,  A61K45/06 ,  A61Q19/08 ,  C07K14/415

    Abstract: PROBLEM TO BE SOLVED: To provide a new composition having marked collagen production-accelerating function.
    SOLUTION: This composition is provided by containing (A) at least one kind selected from a group consisting of ascorbic acid, its derivatives and their salts and (B) at least 1 kind selected from a group consisting of a peptide expressed by Leu-Glu-His-Ala (formula I), its derivatives, and their salts. Further, the composition is provided by containing (A) at least one kind selected from a group consisting of ascorbic acid, its derivatives and their salts and (B) at least 1 kind selected from a peptide having a preservative substitution, deletion and/or addition of ≥1 amino acid in the amino acid sequence of Leu-Glu-His-Ala (formula I), its derivatives, and their salts.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供具有明显的胶原蛋白生产加速功能的新组合物。 解决方案：该组合物通过含有（A）选自抗坏血酸，其衍生物及其盐中的至少一种和（B）至少1种选自由 Leu-Glu-His-Ala（式I），其衍生物及其盐。 此外，组合物通过含有（A）选自抗坏血酸，其衍生物及其盐中的至少一种和（B）至少1种选自具有防腐剂取代，缺失和/或 在Leu-Glu-His-Ala（式I）的氨基酸序列中加入≥1个氨基酸，其衍生物及其盐。 版权所有（C）2008，JPO＆INPIT

    Skin preparation for external use
    10.
    发明专利
    Skin preparation for external use 审中-公开
    外用皮肤制剂

    公开(公告)号：JP2007191396A

    公开(公告)日：2007-08-02

    申请号：JP2006001884

    申请日：2006-01-06

    Applicant: Rohto Pharmaceut Co Ltd ,  ロート製薬株式会社

    Inventor： HARADA AYAKO ,  HONMA YOICHI ,  ABE MASAMICHI

    IPC: A61K8/73 ,  A61K8/14 ,  A61K8/33 ,  A61K8/39 ,  A61K8/55 ,  A61K9/127 ,  A61K31/728 ,  A61K47/08 ,  A61K47/10 ,  A61K47/24 ,  A61P17/16 ,  A61Q19/00

    Abstract: PROBLEM TO BE SOLVED: To provide a skin preparation for external use excellent in percutaneous absorption of hyaluronic acid, hyaluronic acid derivatives or salts of the same.
    SOLUTION: The kin preparation for external use excellent in percutaneous absorption of hyaluronic acid, the hyaluronic acid derivatives or the salts of the same is obtained by bringing the preparation to contain a phospholipid and a glycol ether. Therefore, owing to efficient penetration of hyaluronic acid, the hyaluronic acid derivatives or the salts of the same into the skin, high moisturizing effect, anti-wrinkle effect of giving tension and elasticity to the skin, and the like are expected.
    COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 待解决的问题：提供透明质酸，透明质酸衍生物或其盐的经皮吸收优异的外用皮肤制剂。 解决方案：通过使制剂含有磷脂和二醇醚，可以获得透明质酸的透皮质吸收，透明质酸衍生物或其盐的优异的外用润肤剂制剂。 因此，由于透明质酸的有效渗透，透明质酸衍生物或其盐对皮肤的保湿效果高，对皮肤产生张力和弹性的抗皱作用等。 版权所有（C）2007，JPO＆INPIT

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