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    TREATMENT OF CONFIRMATION AND BEHAVIOR DISORDER ACCOMPANIED BY AGEING AND DEMENTIA SYNDROME
    1.
    发明专利
    TREATMENT OF CONFIRMATION AND BEHAVIOR DISORDER ACCOMPANIED BY AGEING AND DEMENTIA SYNDROME 失效

    公开(公告)号：JPH02108676A

    公开(公告)日：1990-04-20

    申请号：JP21054889

    申请日：1989-08-15

    申请人： UCB SA

    发明人： ERUNSUTO URUFUEERU ,  JIYAN GOBEERU ,  ERITSUKU KOSUMEN

    IPC分类号： C07D251/18 ,  A61K31/53 ,  A61K31/535 ,  A61P25/04

    摘要： A method for the treatment of cognitive and behavioral disorders associated with aging and with dementia syndromes, for example senile dementia, Alzheimer's type, by administering a 2-amino-4-morpholino-6-propyl-1,3,5-triazine of the formula in which R1=hydrogen, alkyl, aralkyl or acetyl, R2=hydrogen, hydroxyl, alkyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, aryl-hydroxyalkyl, (hydroxycycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3, where R3=alkyl, aryl, halogenoaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, CONR4R5, where R4 and R5=hydrogen or alkyl, or R1 and R2 form an alkyleneimino substituted by hydroxyalkyl, and in addition when R1=acetyl, R2=acetoxyalkyl, or a salt thereof.

    2-AMINO-4-MORPHOLYNO-6-PROPYL-1, 3, 5-TRIAZINES
    6.
    发明专利
    2-AMINO-4-MORPHOLYNO-6-PROPYL-1, 3, 5-TRIAZINES 失效

    公开(公告)号：JPH02108675A

    公开(公告)日：1990-04-20

    申请号：JP21054789

    申请日：1989-08-15

    申请人： UCB SA

    发明人： ERITSUKU KOSUMAN ,  JIYAN GOBEERU ,  RORANDO BOIDEN ,  JIYATSUKU MACHIYUU

    IPC分类号： C07D413/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18

    摘要： New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.