Process for production of purified chlorogenic acid-containing pharmaceutical preparation
    3.
    发明专利
    Process for production of purified chlorogenic acid-containing pharmaceutical preparation 有权
    生产纯化含氯酸的药物制备方法

    公开(公告)号:JP2012031165A

    公开(公告)日:2012-02-16

    申请号:JP2011150014

    申请日:2011-07-06

    摘要: PROBLEM TO BE SOLVED: To provide a process for the production of a purified chlorogenic acid-containing pharmaceutical preparation useful in the production of chlorogenic acid-containing beverages which rarely become cloudy even in an acid region.SOLUTION: The process for the production of a purified chlorogenic acid-containing pharmaceutical preparation includes: the first step of dispersing or dissolving a starting chlorogenic acid-containing composition in a mixed solvent consisting of an organic solvent and water in the presence of acid clay or activated clay; the second step of removing a precipitate formed in the dispersion or solution obtained in the first step; the third step of adjusting the solution obtained in the second step to a chlorogenic acid concentration of 1.5 to 10 mass% and a pH of 2 to 4; and the fourth step of removing a precipitate formed in the adjusted solution obtained in the third step.

    摘要翻译: 待解决的问题:提供一种用于生产含绿原酸的饮料的纯化含绿原酸的药物制剂的方法,所述含绿原酸的饮料即使在酸性区域中也很少变得浑浊。 解决方案:用于生产纯化的含绿原酸的药物制剂的方法包括:将起始的含有绿原酸的组合物分散或溶解在由有机溶剂和水组成的混合溶剂中的第一步, 酸性粘土或活性粘土; 除去在第一步骤中获得的分散体或溶液中形成的沉淀物的第二步骤; 将第二工序中得到的溶液调整为绿原酸浓度为1.5〜10质量%,pH为2〜4的第3工序; 以及除去在第三步骤中获得的调节溶液中形成的沉淀物的第四步骤。 版权所有(C)2012,JPO&INPIT