Caustic stable chromatography ligand
    3.
    发明专利
    Caustic stable chromatography ligand 审中-公开
    主要稳定的色谱仪

    公开(公告)号:JP2012229212A

    公开(公告)日:2012-11-22

    申请号:JP2012116704

    申请日:2012-05-22

    摘要: PROBLEM TO BE SOLVED: To provide ligands used in affinity chromatography for the fast and economical purification of a target molecule in high yield.SOLUTION: The alkaline-stable chromatography ligand comprises two or more B domains or two or more Z domains of Staphylococcus protein A (SpA), or a functional fragment or variant thereof, where the two or more B domains or two or more Z domains are attached to a chromatography resin at more than one site on the resin.

    摘要翻译: 要解决的问题:提供用于亲和层析的配体,以高产率快速和经济地纯化目标分子。 解决方案:碱稳定色谱配体包含两个或多个B结构域或葡萄球菌蛋白A(SpA)的两个或多个Z结构域或其功能片段或变体,其中两个或多个B结构域或两个或更多个 Z结构域在树脂上的多个位点连接到色谱树脂上。 版权所有(C)2013,JPO&INPIT

    Corrosion-stable chromatography ligand
    6.
    发明专利
    Corrosion-stable chromatography ligand 有权
    腐蚀性稳定的色谱仪

    公开(公告)号:JP2010156687A

    公开(公告)日:2010-07-15

    申请号:JP2009286006

    申请日:2009-12-17

    IPC分类号: G01N30/88 C07K4/04

    摘要: PROBLEM TO BE SOLVED: To provide a chromatography ligand with improved corrosion stability. SOLUTION: An alkali-stable chromatography ligand includes a B domain with two or more staphylococcus proteins A (SpA), or a Z domain with two or more staphylococcus proteins A (SpA), or these functional fragments or varieties. The alkali-stable chromatography ligand, to which two or more B domains or two or more Z domains adhere on a chromatography resin in two or more sites, further includes a B domain with two or more staphylococcus proteins (SpA), or a Z domain with two or more staphylococcus proteins (SpA), or these functional fragments or varieties. COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译: 要解决的问题:提供具有改善的腐蚀稳定性的色谱配体。 解决方案:碱稳定色谱配体包括具有两个或多个葡萄球菌蛋白A(SpA)的B结构域或具有两个或更多个葡萄球菌蛋白A(SpA)或这些功能片段或品种的Z结构域。 两个或多个B结构域或两个或多个Z结构域粘附在两个或多个位点上的色谱树脂上的碱稳定色谱配体还包括具有两个或多个葡萄球菌蛋白(SpA)或Z结构域的B结构域 与两种或多种葡萄球菌蛋白(SpA)或这些功能片段或品种。 版权所有(C)2010,JPO&INPIT