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    Methods of treatment using the process and fibrous proteins that produce a fibrous protein
    2.
    发明专利
    Methods of treatment using the process and fibrous proteins that produce a fibrous protein 有权

    公开(公告)号：JP5586486B2

    公开(公告)日：2014-09-10

    申请号：JP2010550909

    申请日：2009-03-13

    申请人： アカデミア シニカAcademia Sinica

    发明人： シュウ メイ リュウ ,  チ メイ リュウ ,  ヤン ポ チン ,  チョン ヤン コウ

    IPC分类号： C07K1/113 ,  C07K1/16

    CPC分类号： C07K1/1136 ,  A61K38/162 ,  A61K38/38 ,  A61K38/39 ,  C07K14/765 ,  C07K14/78 ,  C12N2770/32122 ,  C12N2770/32151

    摘要： A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.