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公开(公告)号:JP4315471B2
公开(公告)日:2009-08-19
申请号:JP50452798
申请日:1997-07-02
发明人: エム. ウィンクラー,マシュー , ビー. ドゥボイス,ドゥワイト , エル. パスロスケ,ブリッタン , ブラウン,デイビッド
IPC分类号: C12N15/09 , C07K14/01 , C12N7/04 , C12N15/10 , C12N15/40 , C12N15/86 , C12N15/88 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号: C12N7/00 , C07K14/005 , C12N15/10 , C12N15/86 , C12N15/88 , C12N2740/16022 , C12N2740/16062 , C12N2740/16222 , C12N2770/00022 , C12N2770/00023 , C12N2770/00042 , C12N2770/34022 , C12N2770/34023 , C12N2770/34042 , C12N2770/36123 , C12N2770/36143 , C12N2795/10122 , C12N2795/10142 , C12N2795/18122 , C12N2795/18123 , C12P19/34 , C12Q1/6851 , C12Q1/702 , C12Q1/706 , C12Q1/707 , C12Q2600/158 , C12Q2545/113
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公开(公告)号:JP2009131272A
公开(公告)日:2009-06-18
申请号:JP2009055769
申请日:2009-03-09
IPC分类号: C12N15/09 , A61K9/127 , A61K9/50 , A61K35/76 , A61K39/00 , A61K47/32 , A61K47/36 , A61K47/44 , A61K48/00 , C07K14/01 , C12N7/04 , C12N15/10 , C12N15/40 , C12N15/86 , C12N15/88 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号: C12N7/00 , C07K14/005 , C12N15/10 , C12N15/86 , C12N15/88 , C12N2740/16022 , C12N2740/16062 , C12N2740/16222 , C12N2770/00022 , C12N2770/00023 , C12N2770/00042 , C12N2770/34022 , C12N2770/34023 , C12N2770/34042 , C12N2770/36123 , C12N2770/36143 , C12N2795/10122 , C12N2795/10142 , C12N2795/18122 , C12N2795/18123 , C12P19/34 , C12Q1/6851 , C12Q1/702 , C12Q1/706 , C12Q1/707 , C12Q2600/158 , C12Q2545/113
摘要: PROBLEM TO BE SOLVED: To provide nuclease-resistant nucleic acids in general and ribonuclease-resistant RNAs in particular. SOLUTION: Methods of making and using such nucleic acids are disclosed. Nucleic acid standards comprising nuclease-resistant nucleic acid segments comprising a sequence coding a standard nucleic acid are disclosed, wherein the nucleic acid segments are protected from nuclease decomposition upon cultivation for 5 minutes or more at a room temperature in normal human serum, and problems are solved by the nucleic acid standards. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译: 待解决的问题:提供一般的核酸酶抗性核酸,特别是核糖核酸酶抗性RNA。 解决方案:公开了制备和使用这些核酸的方法。 公开了包含含有编码标准核酸的序列的核酸酶抗性核酸片段的核酸标准品,其中在正常人血清中室温培养5分钟以上时,核酸片段被保护免于核酸酶分解,并且问题是 通过核酸标准解决。 版权所有(C)2009,JPO&INPIT
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