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公开(公告)号：US11621413B2
公开(公告)日：2023-04-04
申请号：US16897407
申请日：2020-06-10
摘要： A positive electrode material which is used in a positive electrode of a lithium ion secondary battery disclosed here includes a positive electrode active material including a compound capable of storing and releasing lithium ions, a first coating material disposed on at least a part of the surface of the positive electrode active material, and a second coating material disposed on at least a part of the surface of the positive electrode active material. The positive electrode material is characterized in that the first coating material contains a nickel oxide having a rock salt structure, and the second coating material contains a titanium oxide.
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公开(公告)号：US20220357217A1
公开(公告)日：2022-11-10
申请号：US17623987
申请日：2020-06-25
发明人： Masazumi FUJIWARA
摘要： An object provide a technique capable of measuring temperature on the basis of optically detected magnetic resonance with higher precision, The object is achieved by a method for measuring the temperature of an object on the basis of optically detected magnetic resonance of an inorganic fluorescent particle, including (a) irradiating the object, containing the inorganic fluorescent particle with each of multiple microwaves having different frequencies, (b) measuring the fluorescence intensities of the inorganic fluorescent particle with individual photon counters at the time of irradiation of respective microwaves, (c) correcting the fluorescence intensities on the basis of dependencies in the number of pulse measurements between the photon counters and (d) Calculating the temperature of the object on the basis of the obtained fluorescence intensity with the correction values.
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3.发明申请公开(公告)号：US20220280601A1
公开(公告)日：2022-09-08
申请号：US17630391
申请日：2020-07-31
发明人： Hiromi KUMON , Hidenori SHIRAHA , Atsushi OYAMA , Daisuke UCHIDA , Masaya IWAMURO , Hiroyuki OKADA
IPC分类号： A61K38/17 , A61P35/00 , A61K33/243 , A61K31/44 , A61K31/47 , A61K31/4439 , A61K31/404 , A61K31/506 , A61K31/517 , A61K45/06 , A61K48/00 , A61K31/282
摘要： This invention provides a method for treatment of hepatic cancer with the use of an anti-tumor agent in combination with the REIC/Dkk-3 gene. This invention also provides a therapeutic agent for treatment of hepatic cancer used in combination with an anti-tumor agent, which comprises, as an active ingredient, the REIC/Dkk-3 gene.
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公开(公告)号：US20220111063A1
公开(公告)日：2022-04-14
申请号：US17298624
申请日：2020-12-17
摘要： One purpose of the present invention aims to provide a novel drug delivery means for targeting neovascularity. Another purpose of the invention is to provide a novel drug delivery means for targeting hyperpermeable vasculature. Still another purpose of the invention is to provide a method and a detection reagent for treatment or diagnosis of various diseases including malignant tumors.
The present conjugate of a drug and an anti-HMGB1 antibody or an antigen-binding fragment thereof is administered to a subject and incorporated into proangiogenic or hyperpermeable vascular endothelial cells to deliver the drug to the cells. In addition, the conjugate is used to provide a method and a detection reagent for treatment or diagnosis of various diseases including malignant tumors.-
公开(公告)号：US20210290598A1
公开(公告)日：2021-09-23
申请号：US17053223
申请日：2019-05-07
IPC分类号： A61K31/423 , A61K31/40 , A61K31/405 , A61K31/366 , A61K31/47 , A61K31/22 , A61K31/505 , A61P9/00
摘要： Provided is a medicament useful for cardiovascular diseases.
An agent for prevention and/or treatment of a cardiovascular diseases, comprising a combination of pemafibrate or a salt thereof and an HMG-CoA reductase inhibitor.-
公开(公告)号：US20210205038A1
公开(公告)日：2021-07-08
申请号：US17206808
申请日：2021-03-19
发明人： Hiroki KITAMURA , Akira Heya , Takafumi Namba , Tetsushi Kamegawa , Takayuki Matsuno , Takao Hiraki
摘要： The invention may provide a puncture robot that can precisely move a needle in the puncture direction by setting needle position in a CT gantry. Provided is a puncture robot comprising a puncture unit, puncture robot being configured such that: the puncture unit comprises a puncture needle, an arm unit, a frame unit, and a base unit; the frame unit comprises a first frame and a second frame that are each provided with an advancing and retracting shaft, and a connecting rod; the arm unit comprises an upper arm and a lower arm, with the puncture needle being mounted to be parallel to the advancing and retracting shaft; and the upper arm and the lower arm are advanced and retracted along the advancing and retracting shaft.
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公开(公告)号：US20210156797A1
公开(公告)日：2021-05-27
申请号：US17092437
申请日：2020-11-09
发明人： Akihiro HONDA , Hideki FUKANO
摘要： A method is provided that allows the sulfur component concentration in gasoline to be estimated to high precision. The measuring method of the disclosure is a method of measuring the concentration of sulfur components in gasoline that contains sulfur components and aromatic components. The measuring method of the disclosure comprises: (A1) removing a portion of the gasoline by gasification to lower the proportion of the aromatic component concentration with respect to the sulfur component concentration in the gasoline, (A2) measuring values related to the refractive index of the gasoline, and (A3) measuring the sulfur component concentration in the gasoline based on the values related to the refractive index.
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公开(公告)号：US20210054061A1
公开(公告)日：2021-02-25
申请号：US17050384
申请日：2019-04-15
申请人： NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , NIIGATA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY , KAWASAKI GAKUENN EDUCATIONAL FOUNDATION
发明人： Masakiyo SAKAGUCHI , Shinichi TOYOOKA , Shuta TOMIDA , Kazuhiko SHIEN , Hiroki SATO , Rie KINOSHITA , Junichiro FUTAMI , Kota ARAKI , Mikio OKAZAKI , Eisaku KONDO , Yusuke INOUE , Akira YAMAUCHI
摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.
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公开(公告)号：US10206979B2
公开(公告)日：2019-02-19
申请号：US15725357
申请日：2017-10-05
申请人： NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人： Tsuyoshi Inoue , Toshiharu Suzuki , Saori Ban
摘要： Disclosed is a method of treatment for anti-Alzheimer's disease based on an action mechanism associated with amyloid β protein, which action mechanism is different from conventional action mechanisms. The treatment Alzheimer's disease uses a therapeutic agent for cognitive impairment induced by amyloid β protein, which therapeutic agent comprises a peptide having the amino acid sequence represented by SEQ ID NO:1 or a peptide similar to this peptide, especially a peptide containing the amino acid sequence represented by SEQ ID NO:2, which is a partial sequence of SEQ ID NO:1. VLSSQQFLHRGHQPPPEMAGHSLASSHRNSMIPSAAT (SEQ ID NO:1) HRGHQPPPEMA (SEQ ID NO:2).
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公开(公告)号：US20180280300A1
公开(公告)日：2018-10-04
申请号：US15766641
申请日：2016-10-06
申请人： Hiroki HAMADA , Yoshio SHIMIZU , ENSUIKO SUGAR REFINING CO., LTD. , National University Corporation Okayama University
发明人： Hiroki HAMADA , Masaharu SENO , Tomonari KASAI , Tsukasa SHIGEHIRO , Koji HARA , Tetsuya ITO , Ichiro FUJIWARA
IPC分类号： A61K9/127 , A61K31/337 , A61K31/7048 , A61K47/24 , A61K47/28 , A61K47/34
摘要： An object of the present invention is to provide a method for encapsulating a poorly water-soluble pharmacologically active substance in a liposome with high efficiency.The present invention provides a composition comprising a lipid having a phosphatidylcholine group, a cholesterol compound, a lipid having a phosphatidylethanolamine group, and a poorly water-soluble pharmacologically active substance, wherein the molar ratio of the lipid having a phosphatidylcholine group, the cholesterol compound, the lipid having a phosphatidylethanolamine group, and the poorly water-soluble pharmacologically active substance is 3 to 8:2 to 7:0.1 to 3:0.001 to 5, respectively.
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