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公开(公告)号:US08604042B2
公开(公告)日:2013-12-10
申请号:US12862517
申请日:2010-08-24
申请人: Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人: Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号: A01N43/54 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
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公开(公告)号:US20130243853A1
公开(公告)日:2013-09-19
申请号:US13888096
申请日:2013-05-06
申请人: TARGEGEN, INC.
发明人: Arvind JAYAN , Janice CACACE , Ayalew TEFFERI
IPC分类号: A61K31/506 , A61K9/48
CPC分类号: A61K31/506 , A61K9/48 , A61K9/4866
摘要: Provided herein are compositions and methods for treating myelofibrosis in a subject. The methods comprise administering to the subject an effective amount of compound which is which is N-tert-butyl-3-[(5-methyl-2-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide or a pharmaceutical salt thereof or a hydrate thereof.
摘要翻译: 本文提供了用于治疗受试者骨髓纤维化的组合物和方法。 所述方法包括向受试者施用有效量的化合物,其为N-叔丁基-3 - [(5-甲基-2 - {[4-(2-吡咯烷-1-基乙氧基)苯基]氨基}嘧啶 -4-基)氨基]苯磺酰胺或其药用盐或其水合物。
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公开(公告)号:US20100330069A1
公开(公告)日:2010-12-30
申请号:US12684312
申请日:2010-01-08
IPC分类号: A61K31/53 , C07D253/10 , C07D401/12 , C07D401/14 , C07D249/14 , C07D403/12 , A61K31/4196 , A61K31/4439 , A61K31/506 , A61K31/501 , A61K39/395 , A61P35/00 , A61J1/05
CPC分类号: A61K31/506 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D213/65 , C07D239/48 , C07D253/06 , C07D271/113 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
摘要翻译: 公开了衍生自苯并三嗪,三嗪,三唑和恶二唑的杂环化合物。 还提供了这种杂环化合物的合成和使用方法。
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公开(公告)号:US07528143B2
公开(公告)日:2009-05-05
申请号:US11588638
申请日:2006-10-26
申请人: Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人: Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号: A01N43/54 , A61K31/505 , C07D239/02 , C07D401/00 , C07D403/00 , C07D407/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译: 本发明提供具有一般结构(A)的联芳基间 - 嘧啶化合物。 本发明的嘧啶化合物能够抑制激酶,例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号:US20060079526A1
公开(公告)日:2006-04-13
申请号:US11212064
申请日:2005-08-24
IPC分类号: C07D253/08 , A61K31/53
CPC分类号: A61K31/506 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D213/65 , C07D239/48 , C07D253/06 , C07D271/113 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
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公开(公告)号:US20130243754A1
公开(公告)日:2013-09-19
申请号:US13722858
申请日:2012-12-20
申请人: TARGEGEN, INC.
IPC分类号: A61K31/506 , C07D403/12 , A61K45/06 , C07D401/12 , A61K31/4439 , A61K31/501
CPC分类号: A61K31/506 , A61K31/4439 , A61K31/501 , A61K45/06 , C07D213/65 , C07D239/48 , C07D253/06 , C07D271/113 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.
摘要翻译: 公开了衍生自苯并三嗪,三嗪,三唑和恶二唑的杂环化合物。 还提供了这种杂环化合物的合成和使用方法。
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公开(公告)号:US20110269721A1
公开(公告)日:2011-11-03
申请号:US13057133
申请日:2009-08-03
申请人: John D. Hood
发明人: John D. Hood
IPC分类号: A61K31/635 , A61K31/5377 , A61P7/06 , A61K31/506
CPC分类号: A61K31/506
摘要: Provided herein are method of treating, ameliorating, or delaying at least one symptom of a genetic blood disorder, e.g. sickle cell disorder or thalassemia, in a patient in need thereof, comprising administering a therapeutically effective amount of a Jak2 inhibitor. Also provided in part is a method of reducing an enlarged spleen in a patient suffering from thalassemia, comprising administering a therapeutically effective amount of a Jak2 inhibitor.
摘要翻译: 本文提供了治疗,改善或延迟遗传性血液病症的至少一种症状的方法,例如, 镰状细胞疾病或地中海贫血,包括给予治疗有效量的Jak2抑制剂。 还部分提供减少患有地中海贫血的患者中的脾脏增大的方法,其包括施用治疗有效量的Jak2抑制剂。
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公开(公告)号:US20110166149A1
公开(公告)日:2011-07-07
申请号:US12866665
申请日:2009-02-06
IPC分类号: A61K31/519 , A61P11/00 , A61P11/08 , A61P11/06
CPC分类号: A61K31/519
摘要: The invention provides methods and compositions for treating asthma and/or COPD. For example, provided herein are compositions that include a kinase inhibiting agent such as 6,7-bis(3-hydroxyphenyl)-pteridine-2,4-diamine or pharmaceutically acceptable salts thereof; and a surfactant.
摘要翻译: 本发明提供了治疗哮喘和/或COPD的方法和组合物。 例如,本文提供了包含激酶抑制剂如6,7-双(3-羟基苯基) - 蝶啶-2,4-二胺或其药学上可接受的盐的组合物; 和表面活性剂。
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公开(公告)号:US07691858B2
公开(公告)日:2010-04-06
申请号:US11789832
申请日:2007-04-25
申请人: John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
发明人: John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
IPC分类号: C07D475/08 , C07D241/20 , C07D241/12 , C07D241/24 , A61K31/4985 , A61P9/08 , A61P11/00 , A61P35/00 , A01N43/50
CPC分类号: C07D475/08
摘要: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
摘要翻译: 组合物和方法,用于治疗与受损的血管淤滞相关的疾病。 本发明的方法和组合物可用于治疗各种疾病,包括例如中风,心肌梗死,癌症,缺血/再灌注损伤,自身免疫疾病如类风湿性关节炎,眼睛疾病如葡萄膜炎,视网膜病变或黄斑变性,黄斑水肿或其他 玻璃体视网膜疾病,诸如自身免疫性疾病,血管渗漏综合征,水肿或涉及白细胞激活的疾病,移植排斥,呼吸系统疾病如哮喘,成人或急性呼吸窘迫综合征(ARDS),慢性阻塞性肺疾病等的炎性疾病。
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公开(公告)号:US20080027070A1
公开(公告)日:2008-01-31
申请号:US11772572
申请日:2007-07-02
申请人: Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
发明人: Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号: A61K31/495 , A61K31/505 , A61P19/02 , A61P27/02 , A61P29/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D239/02
CPC分类号: C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要: Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译: 提供具有一般结构(A)的化合物。 本发明的化合物能够抑制激酶,例如Src激酶家族的成员,Vegfr和各种其它特异性受体和非受体激酶。
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