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公开(公告)号：US20080027070A1
公开(公告)日：2008-01-31
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： A61K31/495 , A61K31/505 , A61P19/02 , A61P27/02 , A61P29/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D239/02
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译： 提供具有一般结构（A）的化合物。 本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20090275569A1
公开(公告)日：2009-11-05
申请号：US12207019
申请日：2008-09-09
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/541 , A61K31/53 , C07D417/12 , C07D413/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08481536B2
公开(公告)日：2013-07-09
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20110294796A1
公开(公告)日：2011-12-01
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/53 , C07D253/10 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/5377 , A61K31/541 , A61P9/10 , A61P35/00 , A61P11/00 , A61P17/02 , A61P19/02 , A61P7/00 , A61P9/00 , A61P37/00 , A61P29/00 , C07D403/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US07456176B2
公开(公告)日：2008-11-25
申请号：US11102405
申请日：2005-04-07
申请人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US08030487B2
公开(公告)日：2011-10-04
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/505 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译： 提供具有一般结构（A）的化合物。 本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20060247250A1
公开(公告)日：2006-11-02
申请号：US11377234
申请日：2006-03-15
申请人： Jianguo Cao , Richard Soll , Glenn Noronha , Kathy Barrett , Colleen Gritzen , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Ute Splittgerber , Binqi Zeng
发明人： Jianguo Cao , Richard Soll , Glenn Noronha , Kathy Barrett , Colleen Gritzen , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Ute Splittgerber , Binqi Zeng
IPC分类号： A61K31/506 , C07D403/14 , C07D403/02
CPC分类号： C07D239/48 , C07D239/49 , C07D401/12 , C07D417/12
摘要： The invention provides pyrimidine compounds having formula A. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式A的嘧啶化合物。本发明的嘧啶化合物能够抑制激酶，例如Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20050245524A1
公开(公告)日：2005-11-03
申请号：US11102405
申请日：2005-04-07
申请人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Ute Splittgerber , Wolfgang Wrasdilo , Ningning Zhao , Elena Dneprovskaia
发明人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John Hood , Chi Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Ute Splittgerber , Wolfgang Wrasdilo , Ningning Zhao , Elena Dneprovskaia
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译： 本发明提供具有式（I）的苯并三嗪化合物。 本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。
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公开(公告)号：US20070161645A1
公开(公告)日：2007-07-12
申请号：US11591252
申请日：2006-10-31
申请人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
IPC分类号： A61K31/506 , A61K31/496 , A61K31/454 , A61K31/427 , A61K31/428 , C07D417/14
CPC分类号： C07D417/12 , C07D239/42 , C07D253/06 , C07D277/42 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/14
摘要： A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophbic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.
摘要翻译： 提供具有通式（A）的化合物：其中A为芳基或杂芳基，Y为亲水连接部分，L为取代基。 化合物（A）可用于治疗各种血管生成相关或血液学疾病，例如对不含有激酶抑制治疗反应的患者中的骨髓增生性疾病，其包括施用目前使用的药物。
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10.发明申请公开(公告)号：US20070149508A1
公开(公告)日：2007-06-28
申请号：US11591076
申请日：2006-10-31
申请人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Binqi Zeng , Chi Mak , Andrew McPherson , Joel Renick , Ved Pathak , Chun Chow , Moorthy Palanki , Richard Soll , Daniel Lohse , John Hood , Elena Dneprovskaia
IPC分类号： A61K31/551 , A61K31/53 , A61K31/506 , C07D403/02
CPC分类号： C07D417/12 , C07D239/42 , C07D253/06 , C07D277/42 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/14
摘要： A compound is provided, having the general structure (A): wherein A is an (un)substituted aryl or (un)substituted heteroaryl moiety, G is N, CH, or CR, R is an unsubstituted or substituted lower alkyl, Y is a hydrophobic linking moiety, and L is a substitutent as defined. The compound (A) can be used for treatment of various angiogenic and hematological-associated disorders, such as myeloproliferative disorder in patients who do not respond to kinase-inhibition therapy that comprises administering approved medications.
摘要翻译： 提供具有一般结构（A）的化合物：其中A是（未）取代的芳基或（未）取代的杂芳基部分，G是N，CH或CR，R是未取代或取代的低级烷基，Y是 疏水连接部分，L是如所定义的取代基。 化合物（A）可用于治疗各种血管生成和血液学相关疾病，例如对不包括施用批准药物的激酶抑制治疗无反应的患者中的骨髓增生性疾病。
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