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公开(公告)号：US20210268096A1
公开(公告)日：2021-09-02
申请号：US17168553
申请日：2021-02-05
摘要： Improvements to vaccines against RSV include G protein CCD portions complexed with mAb that block interaction with CX3C-R and modified forms of mAb to prolong serum half-life, as well as inhalable vaccines.
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公开(公告)号：US20190055304A1
公开(公告)日：2019-02-21
申请号：US16181260
申请日：2018-11-05
发明人： Lawrence M. KAUVAR , Stefan RYSER , Angeles ESTELLES , Reyna J. SIMON , Lauren Opremcak BAKALETZ , Steven David GOODMAN
IPC分类号： C07K16/12 , G01N33/566 , G01N33/569 , A61K39/40 , A61K45/06 , C07K14/31 , A61K49/00 , C12Q1/18
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
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公开(公告)号：US09321839B2
公开(公告)日：2016-04-26
申请号：US14475348
申请日：2014-09-02
发明人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
CPC分类号： C07K16/2863 , C07K16/22 , C07K16/30 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.
摘要翻译： 描述了用于产生特异性结合与胰岛素结合位点不同的位点处的胰岛素依赖型HER3的抗体的重组材料和方法。 这些抗体特别可用于治疗表达HER3的癌症。
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公开(公告)号：US08828388B2
公开(公告)日：2014-09-09
申请号：US13744299
申请日：2013-01-17
发明人： Bruce Keyt , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2863 , C07K16/22 , C07K16/30 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Antibodies which specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
摘要翻译： 描述了在不同于调节蛋白结合位点的位点上特异性结合随机结合的HER3的抗体。 这些抗体特别可用于治疗癌症。
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公开(公告)号：US20220111049A1
公开(公告)日：2022-04-14
申请号：US17560830
申请日：2021-12-23
摘要： Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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公开(公告)号：US09688744B2
公开(公告)日：2017-06-27
申请号：US14697459
申请日：2015-04-27
发明人： Lawrence M. Kauvar , Stote Ellsworth , William Usinger , Krista Maureen McCutcheon , Ying-Ping Jiang , Fen Zhang , Bo Chen , Gizette Sperinde , Minha Park , Orit Foord
IPC分类号： A61K39/395 , C07K16/08 , C07K16/46 , A61K39/245 , A61K39/00
CPC分类号： C07K16/088 , A61K39/245 , A61K2039/505 , C07K16/08 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
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公开(公告)号：US20160237145A1
公开(公告)日：2016-08-18
申请号：US15144681
申请日：2016-05-02
IPC分类号： C07K16/12 , A01N63/02 , G01N33/577 , A61K49/00 , C07K14/31 , G01N33/569 , A61K39/40 , A61K45/06
CPC分类号： C07K16/1271 , A01N63/02 , A61K39/00 , A61K39/40 , A61K45/06 , A61K49/00 , A61K2039/505 , C07K14/31 , C07K16/1214 , C07K16/1228 , C07K16/1242 , C07K16/1275 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12Q1/18 , G01N33/566 , G01N33/56911 , G01N2333/195 , G01N2333/21 , G01N2333/245 , G01N2333/26 , G01N2333/285 , G01N2469/10 , A61K2300/00
摘要： Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
摘要翻译： 描述了能够破坏不同来源的细菌生物膜的结合剂，包括适合于给予所选物种的单克隆抗体，以及包括适体核酸的抗体模拟物。 还描述了防止用这些结合剂形成或溶解生物膜的方法。 还描述了用于引发抗体破坏生物膜的免疫原。
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公开(公告)号：US20130122000A1
公开(公告)日：2013-05-16
申请号：US13744299
申请日：2013-01-17
发明人： Bruce KEYT , Lawrence M. Kauvar , Ellen J. Collarini , Orit Foord , Gizette Sperinde , Marjan Fatholahi , Hung Nguyen
IPC分类号： C07K16/40
CPC分类号： C07K16/2863 , C07K16/22 , C07K16/30 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： Antibodies which specifically bind heregulin-coupled HERS, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer.
摘要翻译： 描述了在不同于调节蛋白结合位点的位点上特异性结合随机结合的HERS的抗体。 这些抗体特别可用于治疗癌症。
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9.发明授权公开(公告)号：US11773143B2
公开(公告)日：2023-10-03
申请号：US16159497
申请日：2018-10-12
IPC分类号： C07K14/135 , A61P31/14 , A61K39/155 , C07K14/005 , A61K39/12 , C07K16/10 , A61K39/00
CPC分类号： C07K14/135 , A61K39/12 , A61K39/155 , A61P31/14 , C07K14/005 , C07K16/1027 , A61K2039/552 , C12N2760/18522 , C12N2760/18533 , C12N2760/18534
摘要： X-ray crystallography has defined conformational properties of a key functional region of the G protein of respiratory syncytial virus (RSV). Mimics of these epitopes have utility as immunogens, as tools for discovery of antibodies and other monoclonal binding agents, and as pharmacological agents to modulate activity of the host receptors for this viral protein.
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10.发明授权公开(公告)号：US10858431B2
公开(公告)日：2020-12-08
申请号：US15619327
申请日：2017-06-09
IPC分类号： C07K16/00 , C12P21/08 , C07K16/28 , A61K39/395 , A61K45/06
摘要： Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
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