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公开(公告)号：US20250154165A1
公开(公告)日：2025-05-15
申请号：US18705801
申请日：2022-10-24
Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) , UNIVERSIDAD DE SEVILLA , ACADEMIA SINICA
Inventor： José Manuel GARCÍA FERNÁNDEZ , Carmen ORTIZ MELLET , Manuel GONZÁLEZ CUESTA , Irene HERRERA GONZÁLEZ , Ya-Jen CHANG , Alan Chuan-Ying LAI
IPC: C07D498/04 , A61K31/439 , A61K39/00 , A61K39/39
Abstract: The invention relates to a multiantennary glycolipid mimetics of formula (I), wherein X, Y, Z and R1 are defined in the description, or a pharmaceutical composition thereof and their use as a medicament, particularly, for the treatment and/or prevention of an immune disease cursed by Th1/Th2 imbalance. Further the invention relates to a vaccine which comprises a compound of formula (I).
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公开(公告)号：US20250136668A1
公开(公告)日：2025-05-01
申请号：US18941224
申请日：2024-11-08
Applicant: ACADEMIA SINICA
Inventor： Kuo-I LIN , Che MA , Chi-Huey WONG , Szu-Wen WANG , Yi-Hsuan CHANG , Xiaorui CHEN , Han-Yi HUANG
Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.
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公开(公告)号：US20250134884A1
公开(公告)日：2025-05-01
申请号：US18926048
申请日：2024-10-24
Applicant: LUMISTAR BIOTECHNOLOGY, INC. , ACADEMIA SINICA
Inventor： Chia-Ning SHEN , Edward Po-Fan CHU , Jen-Chieh CHENG , Yu-Fen CHANG , Wan-Chi SU , Min-Wen CHUNG
IPC: A61K31/496 , A61P3/10
Abstract: A method for treating Type II diabetes. The method involves administering to a subject a pharmaceutical composition comprising an effective amount of a 5-HT1A receptor antagonist. The pharmaceutical composition comprises an effective amount of a 5-HT1A receptor antagonist, and pharmaceutically acceptable carriers thereof.
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公开(公告)号：US20250132035A1
公开(公告)日：2025-04-24
申请号：US18789797
申请日：2024-07-31
Applicant: Academia Sinica
Inventor： Fu-Liang Yang , Justin Chu
IPC: G16H50/00 , G06N3/0464 , G06N3/09
Abstract: The NIBG neural network prediction system based on implicit HbA1c of the present invention comprising a neural network configured to predict BG level of a subject based on implicit HbA1c and cardiovascular signal obtained from the subject. In an embodiment, the subject is not undergoing medical treatment that can affect cardiovascular system of the subject and the neural network is trained using training data from training cohort in which each member of the training cohort is not undergoing medical treatment that can affect cardiovascular system of the subject.
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公开(公告)号：US20250129146A1
公开(公告)日：2025-04-24
申请号：US18572564
申请日：2022-06-24
Applicant: ACADEMIA SINICA
Inventor： Han-Chung WU , Sushree Shankar PANDA
IPC: C07K16/22 , A61K31/497 , A61K39/00 , A61P35/00
Abstract: The present invention relates to combined therapy of cancer using an epithelial cell adhesion molecule (EpCAM) inhibitor and a Wnt signaling inhibitor. Specifically, the EpCAM inhibitor is an antibody which is directed to an extracellular domain (EpEX) of EpCAM. The combined therapy is effective in inducing apoptosis of cancer cells, inhibiting cancer sternness properties, tumor progression and/or metastasis, and/or prolonging survival of a cancer patient.
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Patent Agency Ranking
公开(公告)号：US12252551B2
公开(公告)日：2025-03-18
申请号：US16978278
申请日：2019-03-05
Applicant: Academia Sinica
Inventor： Chih-Cheng Chen , Yu-Chia Chuang
IPC: C07K16/18 , A61K31/135 , A61K31/195 , A61K31/485 , A61K45/06 , A61P25/00 , C07K16/28 , C07K16/44 , A61K39/00
Abstract: Disclosed herein are method and/or kit for rendering a diagnosis on whether a subject is suffering from peripheral neuropathy pain. The method comprises detecting the presence of advillin in a biological sample by forming an immune complex between advillin and a monoclonal antibody specifically binds thereto. Also disclosed herein is a method of treating a subject suffering from peripheral neuropathy pain.
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公开(公告)号：US20250029978A1
公开(公告)日：2025-01-23
申请号：US18222627
申请日：2023-07-17
Applicant: Academia Sinica
Inventor： Maw-Kuan WU , Yu-Hsuan SU , Chin-Yi CHUNG , Yan-Reui CHEN , Feng-Yu WU , Po-Wei CHI , Phillip M. WU
IPC: H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/62 , H01M10/0525
Abstract: An electrode for a lithium-ion battery is provided, which comprises: a current collector; and an electrode material layer disposed on the current collector, wherein the electrode material layer comprises an anode material and a binder, the binder is pectin, its derivative or a combination thereof, and the anode material is selected from the group consisting of lithium vanadium oxide, lithium titanium oxide, lithium iron oxide, graphite, and a combination thereof. In addition, a lithium-ion battery comprising the aforesaid electrode is also provided.
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公开(公告)号：US12178870B2
公开(公告)日：2024-12-31
申请号：US18662436
申请日：2024-05-13
Applicant: ACADEMIA SINICA
Inventor： Chi-Huey Wong , Hsin-Yu Liao , Shih-Chi Wang , Yi-An Ko , Kuo-I Lin , Che Ma , Ting-Jen Cheng
IPC: A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/16 , C07K14/005 , C07K14/11
Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).
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公开(公告)号：US12171729B2
公开(公告)日：2024-12-24
申请号：US17779048
申请日：2020-11-25
Applicant: The Johns Hopkins University , Academia Sinica , National Yang Ming Chiao Tung University
Inventor： Ru Chih C. Huang , Jong Ho Chun , Yu-Ling Lin , Yu-Chuan Liang , Kuang-Wen Liao , Tiffany Jackson , David Mold , Chien-Hsien Lai
IPC: A61K31/05 , A61K9/00 , A61K31/09 , A61K31/444 , A61K31/495 , A61K47/14 , A61K47/22 , A61P35/00
Abstract: The present invention provides novel pharmaceutical formulations comprising derivatives of NDGA, including M4N (tetra-0-methyl nordihydroguaiaretic acid) and temozolomide and their use in the inhibition and treatment of neoplastic diseases, including glioblastoma multiforme, lung and other cancers.
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公开(公告)号：US20240420944A1
公开(公告)日：2024-12-19
申请号：US18701598
申请日：2022-10-12
Applicant: Academia Sinica
Inventor： Yi-Sheng WANG , Yi-Hong CAI
Abstract: Provided herein are designs of a linear time-of-flight (TOF) mass spectrometer that achieves a high mass resolving power (MRP) to ions independently having a mass-to-charge (m/z) ratio between 1,000 and 100,000. The TOF mass spectrometer comprises an ion source, a flight tube, and an ion detector, in which the ion source comprises a sample plate, an extraction plate disposed at a first distance (d1) away from the sample plate; an end plate disposed at a second distance (d2) away from the extraction plate; a first electric field (e1) present between the sample plate and the extraction plate; and a second electric field (e2) present between the extraction plate and the end plate; the flight tube having a length of d3 is disposed downstream and adjacent to the ion source; and the ion detector is disposed downstream and adjacent to the flight tube; and the linear TOF mass spectrometer satisfies the set of criteria I or II, in which the set of criteria I includes (1) d1/L
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