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公开(公告)号:US20250102360A1
公开(公告)日:2025-03-27
申请号:US18896776
申请日:2024-09-25
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ZANDEF DEKSIT INC. , DESERT BOTANICAL GARDENS
Inventor: Jnaneshwar DAS , Rakshith VISHWANATHA , Cole BRAUER , Zhiang CHEN , Lakshmi ANTERVEDI , Harish ANAND , Sophia DAVIS , Darwin MICK , Luiza APARECIDO , Kshitij SRIVASTAVA , Heather THROOP , Devin KEATING , Alejandro CUEVA RODRIGUEZ , Desmond HANAN , Kevin HULTINE , Amanda CLARKE , Jason Achilles MEZILIS , Roberta MARTIN , Elizabeth TREMBATH-REICHERT , Ramón ARROWSMITH
Abstract: An environmental monitoring system with a plurality of sensor units and an imaging system. The sensor units are configured to be distributed over a monitored area and to collect spatiotemporal data. Each of the sensor units may have a temperature sensor, an air pressure sensor, a humidity sensor, a clock, and/or a Wi-Fi transceiver. The sensor units are configured to communicatively couple together to form a sensor network. The imaging system may be configured both for handheld use and for mounted use. The imaging system may have a camera and a spectrometer. The imaging system is configured to generate a real-time semantic map of the area and position the sensor units on the semantic map. The environmental monitoring system is configured to use the semantic map and the spatiotemporal data to predict a need of the monitored area and variation of the need across the monitored area.
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公开(公告)号:US20250095347A1
公开(公告)日:2025-03-20
申请号:US18293315
申请日:2022-08-24
Inventor: Roy Asim
IPC: G06V10/82 , G06V10/778
Abstract: Described herein are means for systematically generating transparent models for computer vision and image recognition utilizing deep learning non-transparent black box models. According to a particular embodiment, there is a specially configured system for generating an explainable AI model by performing operations, including: training a Convolutional Neural Network (CNN) to classify objects; training a Convolutional Neural Network (CNN) to classify objects from training data having a set of training images; training a multi-layer perceptron (MLP) to recognize both the objects and parts of the objects; generating the explainable AI model based on the training of the MLP; receiving an image having an object embedded therein, wherein the image forms no portion of the training data for the explainable AI model; executing the CNN and the explainable AI model within an image recognition system, and generating a prediction of the object in the image via the explainable AI model; recognizing parts of the object; providing the parts recognized within the object as evidence for the prediction of the object; and generating a description of why the image recognition system predicted the object in the image based on the evidence comprising the recognized parts.
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公开(公告)号:US20250084157A1
公开(公告)日:2025-03-13
申请号:US18829906
申请日:2024-09-10
Inventor: Michael SIERKS , Huilai TIAN
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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公开(公告)号:US20250074803A1
公开(公告)日:2025-03-06
申请号:US18820649
申请日:2024-08-30
Applicant: Dennis Grubb , Arizona Board of Regents on behalf of Arizona State University , FREEPORT MINERALS CORPORATION
Inventor: Anca Delgado , Evelyn Miranda , Nasser Hamdan , Leonard Santisteban , Dennis Grubb
IPC: C02F3/34 , C02F3/28 , C02F101/10 , C02F101/20 , C02F103/10
Abstract: Described herein is a method of purifying contaminated fluid influent, the method comprising: providing a reactor comprising a reactor inlet, a reactor outlet, and a purification composition; circulating contaminated fluid influent through the reactor to create a slag-treated fluid; providing a biochemical reactor comprising a biochemical reactor inlet, a biochemical reactor outlet, and a purification media; and circulating the slag-treated fluid through the biochemical reactor to generate a purified fluid. Also described herein is a contaminated fluid influent purification system, comprising: a reactor having a reactor inlet, a reactor outlet, and a purification composition; a biochemical reactor having a biochemical reactor inlet, a biochemical outlet, and a purification media; a settling tank; and a mixing tank; wherein the mixing tank is fluidly connected to a contaminated fluid influent source, the reactor and the settling tank; and wherein the settling tank is fluidly connected to the mixing tank and the biochemical reactor.
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公开(公告)号:US20250073325A1
公开(公告)日:2025-03-06
申请号:US18597598
申请日:2024-03-06
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , BAYLOR COLLEGE OF MEDICINE
Inventor: Sri KRISHNA , Marshall POSNER , Andrew SIKORA , Karen ANDERSON
Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
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公开(公告)号:US12241855B2
公开(公告)日:2025-03-04
申请号:US18335818
申请日:2023-06-15
Applicant: Board of Regents, The University of Texas System , Arizona Board of Regents on Behalf of Arizona State University , William Marsh Rice University
Inventor: Dino Villagran , Paul Westerhoff , Jonathan Josue Calvillo Solis , Michael Wong
Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%. Providing the electrochemical sensor can include providing at least one member selected from the group consisting of perfluoro-1-octanethiol (PFTO), 2,2,2-trifluoroethanethiol (TFET) or perfluorodecanethiol (PFDT) on the surface of the glassy carbon substrate.
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公开(公告)号:US20250058266A1
公开(公告)日:2025-02-20
申请号:US18815777
申请日:2024-08-26
Inventor: Klaus LACKNER , Shreyans KEDIA , Venkatram CHOODAMANI , Robert PAGE
IPC: B01D53/04
Abstract: A device for passive collection of atmospheric carbon dioxide is disclosed. The device includes a release chamber having an opening and a sorbent regeneration system. The device also includes a capture structure coupled to the release chamber, having at least one collapsible support and a plurality of tiles spaced along the collapsible support. Each tile has a sorbent material. The capture structure is movable between a collection configuration and a release configuration. The collection configuration includes the capture structure extending upward from the release chamber to expose the capture structure to an airflow and allow the sorbent material to capture atmospheric carbon dioxide. The release configuration includes the collapsible support being collapsed and the plurality of tiles being sufficiently enclosed inside the release chamber that the sorbent regeneration system may operate on the plurality of tiles to release captured carbon dioxide from the sorbent material and form an enriched gas.
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公开(公告)号:US12220369B2
公开(公告)日:2025-02-11
申请号:US16858302
申请日:2020-04-24
Applicant: Arizona Board of Regents on behalf of Arizona State University , Dignity Health , Luis Lopez
Inventor: Thomas Sugar , Luis Lopez , Lee Griffith , Robin Parmentier , Saivimal Sridar , Pham Huy Nguyen , Jeremy Palmiscno , Will Meredith
Abstract: A soft wearable medical device may comprise a force actuation system at least partially disposed in a glove assembly. The force actuation system may be a passive or active actuation system. The force actuation system may be configured to adjust a grip of a patient during use of the soft wearable medical device. The soft wearable medical device may further comprise a force indication system including a plurality of force sensors and a light array, each force sensor disposed in a finger of the glove assembly and the light array mounted to the glove assembly.
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公开(公告)号:US12216737B2
公开(公告)日:2025-02-04
申请号:US17698805
申请日:2022-03-18
Inventor: Zongwei Zhou , Jae Shin , Jianming Liang
IPC: G06V10/82 , G06F18/21 , G06F18/214 , G06T7/00 , G06V10/764 , G16H30/40
Abstract: Described herein are systems, methods, and apparatuses for actively and continually fine-tuning convolutional neural networks to reduce annotation requirements, in which the trained networks are then utilized in the context of medical imaging. The success of convolutional neural networks (CNNs) in computer vision is largely attributable to the availability of massive annotated datasets, such as ImageNet and Places. However, it is tedious, laborious, and time consuming to create large annotated datasets, and demands costly, specialty-oriented skills. A novel method to naturally integrate active learning and transfer learning (fine-tuning) into a single framework is presented to dramatically reduce annotation cost, starting with a pre-trained CNN to seek “worthy” samples for annotation and gradually enhances the (fine-tuned) CNN via continual fine-tuning. The described method was evaluated using three distinct medical imaging applications, demonstrating that it can reduce annotation efforts by at least half compared with random selection.
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公开(公告)号:US20250035627A1
公开(公告)日:2025-01-30
申请号:US18778278
申请日:2024-07-19
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , Mayo Foundation for Medical Education and Research
Inventor: Shaopeng WANG , Nanxi YU , Chao CHEN , Xinyu ZHOU , Januario E. CASTRO , Eider F. Moreno Cortes
IPC: G01N33/569 , B01L3/00 , C12N5/00 , G01N33/543 , G01N33/68 , G06V10/70
Abstract: Provided herein are methods of differentiating cell types in a cell population. The methods include removing at least some non-Chimeric Antigen Receptor (CAR)-T cells from a fluidic sample obtained from a subject without centrifuging the fluidic sample to produce a purified fluidic sample. The fluidic sample comprises CAR-T cells and the non-CAR-T cells. The methods also include capturing cells in the purified fluidic sample on a surface that comprises binding moieties that bind at least to the CAR-T cells to produce a captured cell population. In addition, the methods also include distinguishing the CAR-T cells from the non-CAR-T cells in the captured cell population using a trained machine learning model to produce a captured CAR-T cell population data set. Additional methods as well as related devices and systems are also provided.
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