Method for assaying immunologically active substance and reagent therefor
    1.
    发明授权
    Method for assaying immunologically active substance and reagent therefor 失效
    用于测定免疫活性物质及其试剂的方法

    公开(公告)号:US5296355A

    公开(公告)日:1994-03-22

    申请号:US678326

    申请日:1991-06-12

    摘要: A method for assaying an immunologically active substance based on the antigen-antibody reaction in a liquid phase, and a reagent for use in the method are disclosed. This method comprises adding a reagent containing a compound represented by the general formulaR.sup.1 O---[(CH.sub.2 CH.sub.2 O).sub.m (AO).sub.n ]--R.sup.2(wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a hydrocarbyl group containing 1 to 5 carbon atoms, AO represents an oxyalkylene group containing 3 to 4 carbon atoms, m and n represent the number of oxyethylene groups and that of oxyalkylene groups, respectively, with said oxyethylene groups and oxyalkylene groups forming a random copolycondensate and having a molecular weight of 1000 to 20000, and the ratio of m/n being 60/40 to 90/10).

    摘要翻译: PCT No.PCT / JP89 / 01051 Sec。 371日期1991年6月12日 102(e)日期1991年6月12日PCT提交1989年10月12日PCT公布。 公开号WO90 / 04179 日本1990年04月19日。基于液相中的抗原 - 抗体反应测定免疫活性物质的方法和用于该方法的试剂。 该方法包括加入含有通式R 1 -O - ((CH 2 CH 2 O)m(AO)n)-R 2(其中R 1和R 2各自表示氢原子或含有1至5个碳原子的烃基) AO表示含有3〜4个碳原子的氧化烯基,m和n分别表示氧化乙烯基和氧化烯基的数量,所述氧化乙烯基和氧化烯基形成无规共聚缩聚物,分子量为1000〜20000, m / n的比例为60/40〜90/10)。

    Polymer-drug conjugate and a method of producing it
    2.
    发明授权
    Polymer-drug conjugate and a method of producing it 失效
    聚合物 - 药物共轭物及其生产方法

    公开(公告)号:US5130126A

    公开(公告)日:1992-07-14

    申请号:US676384

    申请日:1991-03-28

    IPC分类号: A61K31/557 A61K47/48

    摘要: The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

    摘要翻译: 本发明提供了具有消化器官方向特性的聚合物组合药物,其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。 通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物(如果需要在溶剂中)和必要时在催化剂存在下反应来制备聚合物组合药物。 能够口服给药或静脉注射,以保持血液中的浓度长时间稳定,并直接吸收或摄入消化器官如肠胃。

    Hair-rinse liquid with pearly luster
    6.
    发明授权
    Hair-rinse liquid with pearly luster 失效
    漂亮的液体与珍珠光泽

    公开(公告)号:US4592907A

    公开(公告)日:1986-06-03

    申请号:US713980

    申请日:1985-03-20

    摘要: It is proposed a hair-rinse liquid having pearly luster, which includes the following four components A to D, namely:component A: a cationic surface active agent expressed by the general formula (I), as given below;component B: an amine oxide represented by the general formula (II), as given also in below;component C: an amino acid having an isoelectric point not higher than 7 andcomponent D: a salt of an alkali metal or alkaline earth metal. ##STR1## In the above formulae (I) and (II), R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent each a hydrocarbon group or a hydroxy alkyl group having 1-24 carbon atoms, which may be identical or different with each other, and the sum of the total carbon atoms in each formula should lie within the range of 16-45 and X denotes a halogen atom.

    摘要翻译: 提出了具有珠光泽的漂白液,其包括以下四种组分A至D,即:组分A:由通式(I)表示的阳离子表面活性剂,如下所示; 组分B:由下列通式(II)表示的氧化胺: 组分C:等电点不高于7的氨基酸,组分D:碱金属或碱土金属的盐。 (II)在上述式(I)和(II)中,R 1,R 2,R 3和R 4各自表示烃基或具有1-24个碳原子的羟烷基, 彼此相同或不同,每个式中的总碳原子总和应在16-45的范围内,X表示卤素原子。

    Suppository base composition
    7.
    发明授权
    Suppository base composition 失效
    栓剂基础组成

    公开(公告)号:US4462984A

    公开(公告)日:1984-07-31

    申请号:US425101

    申请日:1982-09-27

    IPC分类号: A61K9/02

    CPC分类号: A61K9/02 Y10S424/15

    摘要: A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

    摘要翻译: 包含5-80重量%的聚乙二醇,5-80重量%的具有6-22个碳原子的脂肪酸的甘油三酯和5-80重量%的特异性有限的环氧烷衍生物的栓剂基础组合物具有熔点 30℃〜60℃,与极性药物成分和非极性药物成分的相溶性,能够提供成型性和保存稳定性优异的栓剂。