公开(公告)号：US20080081888A1

公开(公告)日：2008-04-03

申请号：US11863977

申请日：2007-09-28

Applicant: Kazuhiro KUBO ,  Shigeru KITANO ,  Chika ITO

Inventor： Kazuhiro KUBO ,  Shigeru KITANO ,  Chika ITO

IPC: C08F4/46

CPC classification number: C08L71/02 ,  C08L2205/05 ,  C08L2666/18

Abstract: A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

Abstract translation: 一种可生物降解的聚氧化烯衍生物的制造方法，其特征在于，包括：使如本文所定义的式（1）表示的生物可降解聚氧化烯化合物与本文所定义的式（I）〜（IV）之一所表示的化合物在 碱性固体盐，可生物降解的聚氧化烯衍生物由如本文所定义的式（2）表示。

公开(公告)号：US5540935A

公开(公告)日：1996-07-30

申请号：US349362

申请日：1994-12-05

Applicant: Tsuyoshi Miyazaki ,  Kazuo Maruyama ,  Motoharu Iwatsuru ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

Inventor： Tsuyoshi Miyazaki ,  Kazuo Maruyama ,  Motoharu Iwatsuru ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

IPC: A61K9/127 ,  A61K47/48 ,  C07F9/6506 ,  C08G65/332 ,  C08G65/335

CPC classification number: A61K9/1271 ,  A61K47/48823 ,  C07F9/65061 ,  C08G65/3328 ,  C08G65/335 ,  Y10T428/2984

Abstract: A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Abstract translation: 1.一种活性囊泡，其特征在于，作为泡囊形成成分，含有由以下通式（1）表示的反应性磷脂衍生物和通过使所述活性囊泡与功能性物质反应制备的功能性物质固定的囊泡： 其中R1C（= O）和R2C（= O）各自表示脂族酰基，R3表示氢原子或甲基，OA表示2-4个碳原子的氧化烯基，n表示加入的氧化烯基团的平均摩尔数 并且为1-1,000，p为0或1，X表示，其中q和r各自为0至4或1至4的整数，M表示氢原子或烷基金属原子。

公开(公告)号：US5478575A

公开(公告)日：1995-12-26

申请号：US37383

申请日：1993-03-26

Applicant: Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

Inventor： Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

IPC: A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48 ,  A61K38/28

CPC classification number: A61K9/0019 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48176 ,  A61K47/4823 ,  Y10S514/866

Abstract: The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

Abstract translation: 本发明提供了在聚合物中具有硼酸基团的糖响应型聚合物复合物。 药物可以包含或连接，优选地，药物具有羟基。 具有硼酸基团的聚合物和具有羟基的药物可以通过硼酸酯键连接。 络合物还可以包含具有硼酸基团的聚合物和具有羟基的聚合物，并且这些聚合物可以是交联的。

公开(公告)号：US4782455A

公开(公告)日：1988-11-01

申请号：US51171

申请日：1987-05-18

Applicant: Kinya Morinouchi ,  Shigeru Kitano

Inventor： Kinya Morinouchi ,  Shigeru Kitano

IPC: G06K7/016 ,  G06K13/067 ,  G06F15/02 ,  G06K5/00

CPC classification number: G06K7/016 ,  G06K13/067

Abstract: A card reader control system includes a measuring device which measures a time interval of a clock signal which is developed from a card reader when a card is manually driven to travel in the card reader. The card reader control system stores the maximum time interval and the minimum time interval of the clock signal measured by the measuring device. When either one or both of the maximum time interval and the minimum time interval is not included in a preferred range, an alarm buzzer is enabled to indicate that the card speed is not suited for the reading operation.

Abstract translation: 读卡器控制系统包括测量装置，其测量当卡被手动驱动以在读卡器中行进时从读卡器开发的时钟信号的时间间隔。 读卡器控制系统存储由测量装置测量的时钟信号的最大时间间隔和最小时间间隔。 当优选范围中不包括最大时间间隔和最小时间间隔中的任何一个或两者时，使能警报蜂鸣器来指示卡速度不适于读取操作。

公开(公告)号：US5463066A

公开(公告)日：1995-10-31

申请号：US349368

申请日：1994-12-05

Applicant: Tsuyoshi Miyazaki ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

Inventor： Tsuyoshi Miyazaki ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

IPC: A61K9/127 ,  A61K47/48 ,  C07D233/64 ,  C07F9/6506 ,  C08G65/332 ,  C08G65/335

CPC classification number: C08G65/3328 ,  A61K47/48238 ,  A61K47/48815 ,  A61K9/1271 ,  C07F9/65061 ,  C08G65/335

Abstract: A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

Abstract translation: 用于反应性泡囊形成剂的新型有用的磷脂衍生物，其由以下通式（1）表示：各自为脂族酰基，R 3表示氢原子或甲基，OA表示氧化烯基 2-4个碳原子，n表示加成的氧化烯基的平均加成摩尔数，为1-1000，p为0或1，X为4或1〜4，M为氢原子或碱金属原子 。

公开(公告)号：US5981786A

公开(公告)日：1999-11-09

申请号：US230605

申请日：1999-01-27

Applicant: Shigeru Kitano ,  Toshihiko Ohta ,  Hiroshi Suzuki ,  Akio Hayashi ,  Yoshishige Murata ,  Kazuo Matsuyama ,  Kenichiro Nakamoto

Inventor： Shigeru Kitano ,  Toshihiko Ohta ,  Hiroshi Suzuki ,  Akio Hayashi ,  Yoshishige Murata ,  Kazuo Matsuyama ,  Kenichiro Nakamoto

IPC: C07F9/09 ,  C07F9/6574 ,  C07F9/10

CPC classification number: C07F9/65742 ,  C07F9/091

Abstract: A process for producing a (meth)acrylate derivative including reacting a compound of formula (1) (wherein R.sup.1 is H or CH.sub.3 ; A is C.sub.1 -C.sub.10 alkylene; and p is 1 to 10) with a chloro-dioxaphosphorus compound of formula (2) (wherein q is 0 or 1) in the presence of a secondary amine of formula (3) (wherein R.sup.2 and R.sub.3 are each C.sub.3 -C.sub.8 alkyl, cycloalkyl, C.sub.6 -C.sub.9 aryl, arylalkyl, etc.) to produce a (meth)acrylate derivative of formula (4) and further reacting the same with a tertiary amine of formula (5) (wherein R.sup.4, R.sup.5 and R.sup.6 are each C.sub.1 -C.sub.4 alkyl etc.) to provide a (meth)acrylate derivative of formula (6). ##STR1##

Abstract translation: PCT No.PCT / JP98 / 02357 Sec。 371日期1999年1月27日第 102（e）日期1999年1月27日PCT提交1998年5月28日PCT公布。 公开号WO98 / 54194 日期：1988年12月3日一种制备（甲基）丙烯酸酯衍生物的方法，包括使式（1）的化合物（其中R 1为H或CH 3; A为C 1 -C 10亚烷基; p为1至10） 式（2）的二氧杂磷化合物（其中q为0或1）在式（3）的仲胺存在下（其中R 2和R 3各自为C 3 -C 8烷基，环烷基，C 6 -C 9芳基，芳基烷基等） ）以制备式（4）的（甲基）丙烯酸酯衍生物，并使其与式（5）的叔胺进一步反应（其中R 4，R 5和R 6各自为C 1 -C 4烷基等），以提供（甲基） 丙烯酸酯衍生物（6）。

公开(公告)号：US08557929B2

公开(公告)日：2013-10-15

申请号：US11863977

申请日：2007-09-28

Applicant: Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

Inventor： Kazuhiro Kubo ,  Shigeru Kitano ,  Chika Ito

IPC: C08F4/46 ,  C08G65/329

CPC classification number: C08L71/02 ,  C08L2205/05 ,  C08L2666/18

Abstract: A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

Abstract translation: 一种可生物降解的聚氧化烯衍生物的制造方法，其特征在于，包括：使如本文所定义的式（1）表示的生物可降解聚氧化烯化合物与本文所定义的式（I）〜（IV）之一所表示的化合物在 碱性固体盐，可生物降解的聚氧化烯衍生物由如本文所定义的式（2）表示。

公开(公告)号：US20060252908A1

公开(公告)日：2006-11-09

申请号：US10538799

申请日：2002-12-13

Applicant: Atsuhiko Ogura ,  Shinji Tanaka ,  Yoshikazu Nakashima ,  Shigeru Kitano

Inventor： Atsuhiko Ogura ,  Shinji Tanaka ,  Yoshikazu Nakashima ,  Shigeru Kitano

IPC: C08G69/10

CPC classification number: A61L31/148 ,  A61L31/06 ,  C08G73/02 ,  C08G73/024 ,  C08G73/028 ,  C08L79/02

Abstract: A novel A1-B-A2 polymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even when embedded in a large amount in the body, has good kinetic properties, and is useful for preparing tissue anti-adhesion films. This polymer is composed of segments A1 and A2 each having at least either of modified and unmodified amino acid groups, and segment B composed of PEG having a number average molecular weight of 8000 to 50000. The polymer contains both the modified and unmodified amino acid groups, the content of the modified amino acids is 20 to 85 mol % of all the amino acids in the polymer, and segment A1 is bonded to one end of segment B and segment A2 is bonded to the other end of segment B.

Abstract translation: 提供了数均分子量为10000〜100000的新型的高分子聚合物，其具有优异的生物吸收性，即使在预定时间内即使在 在体内大量嵌入，具有良好的动力学性质，对制备组织抗粘膜有用。 该聚合物由具有至少修饰的和未修饰的氨基酸基团中的至少一个的片段A 1和A 2组成，并且由具有数均分子量的PEG构成的片段B 该聚合物含有经修饰和未修饰的氨基酸基团，修饰氨基酸的含量为聚合物中所有氨基酸的20至85mol％，段A < 被结合到段B的一端，段A 2结合到段B的另一端。

公开(公告)号：US4351008A

公开(公告)日：1982-09-21

申请号：US114745

申请日：1980-01-24

Applicant: Daisuke Mochizuki ,  Shigeru Kitano

Inventor： Daisuke Mochizuki ,  Shigeru Kitano

IPC: G11B20/10 ,  G06F3/06 ,  G06F13/38 ,  G11B20/14 ,  G11B27/032 ,  H04L7/00 ,  G11B5/09

CPC classification number: G06F3/0601 ,  G11B27/032 ,  G06F2003/0698

Abstract: An improved modulator is capable of facilitating recording and reproducing on and from an audio cassette tape digital signals such as programs and numerical data coming from digital signal processing apparatus including an electronic cash register as well as providing safety for the audio cassette tape when in operation. The modulator includes a control circuit for detecting and counting carrier signals and outputting desired information in response to a data transfer instruction and a state detector governed by the control circuit wherein the carrier signals are sent out via data transfer lines when the detector is in a specific state. The control circuit may be implemented with a microprocessor.

Abstract translation: 一种改进的调制器能够便利地在来自音频盒式磁带的数字信号（例如来自包括电子收款机的数字信号处理设备的程序和数字数据）中进行记录和再现，并且在操作时为音频盒式磁带提供安全性。 该调制器包括一个控制电路，用于检测和计数载波信号并输出​​响应于数据传输指令的所需信息和由控制电路管理的状态检测器，其中当检测器处于特定的状态时，通过数据传输线将载波信号发送出去 州。 控制电路可以用微处理器来实现。

公开(公告)号：US4313180A

公开(公告)日：1982-01-26

申请号：US117004

申请日：1980-01-30

Applicant: Daisuke Mochizuki ,  Shigeru Kitano

Inventor： Daisuke Mochizuki ,  Shigeru Kitano

IPC: G11C11/405 ,  G11C5/14 ,  G11C11/406 ,  H02J9/06 ,  G11C7/00

CPC classification number: G11C11/406 ,  G11C5/141 ,  H02J9/06

Abstract: An electronic apparatus comprises a central processor unit (CPU) for controlling the operation of the electronic apparatus, and a dynamic random access memory (RAM). The CPU develops a refresh control signal for refreshing the memory data stored in the dynamic RAM. An additional refresh control circuit is provided outside of the CPU for developing another refresh control signal. The additional refresh control circuit is connected to receive the electric power from a backup battery included in the electronic apparatus. When the service interruption occurs, the additional refresh control circuit is enabled to maintain the memory data stored in the dynamic RAM.

Abstract translation: 电子设备包括用于控制电子设备的操作的中央处理器单元（CPU）和动态随机存取存储器（RAM）。 CPU产生用于刷新存储在动态RAM中的存储器数据的刷新控制信号。 在CPU外部提供另外的刷新控制电路，用于开发另一刷新控制信号。 连接附加的刷新控制电路以从包括在电子设备中的备用电池接收电力。 当服务中断发生时，附加刷新控制电路能够维持存储在动态RAM中的存储器数据。