-
公开(公告)号：US07829524B2
公开(公告)日：2010-11-09
申请号：US10560260
申请日：2004-06-10
申请人： Dorotea Raventos Segura , Per Holse Mygind , Hans-Henrik Kristensen Hoegenhaug , Alessandro Tossi
发明人： Dorotea Raventos Segura , Per Holse Mygind , Hans-Henrik Kristensen Hoegenhaug , Alessandro Tossi
CPC分类号： C11D3/48 , A01N37/46 , A23K20/147 , A23K20/174 , A23K20/189 , A23K20/195 , A23K20/30 , A23K50/00 , A23K50/75 , A23K50/80 , A61K38/00 , C07K14/001 , C07K14/47 , C11D3/3719 , C11D3/38 , Y02A40/818
摘要： The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有抗微生物活性的多肽和具有编码多肽的核苷酸序列的多核苷酸。 本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。
-
2.发明授权Peptidomimetic inhibitors of retroviral proteases and their use as antivirals 失效逆转录病毒蛋白酶的拟肽抑制剂及其作为抗病毒剂的用途公开(公告)号：US07691818B2
公开(公告)日：2010-04-06
申请号：US11629720
申请日：2005-06-15
IPC分类号： A61K38/08 , A61K38/06 , A61K38/05 , A61K38/04 , A61K31/401
CPC分类号： C07D207/08 , A61K31/401 , A61K31/405 , C07D207/09
摘要： New peptidomimetic inhibitors of retroviral proteases are in particular for human immunodeficiency virus (HIV) protease. These inhibitors include as the core structure a new diamiriodiol isostere of the dipeptide Phe-Pro having four stereogenic centers. The inhibitors have been shown to inhibit HIV-protease and can therefore be usefully employed as antivirals for post-exposure prophylaxis and as a therapy for viral infections by a retrovirus, in particular HIV. The syntheses processes of the isosteres and inhibitors are also described.
摘要翻译： 逆转录病毒蛋白酶的新肽模拟抑制剂尤其适用于人类免疫缺陷病毒（HIV）蛋白酶。 这些抑制剂包括作为核心结构的具有四个立体中心的二肽Phe-Pro的新的二酰胺基等离子体。 已经显示抑制剂抑制HIV-蛋白酶，因此可以有用地用作暴露后预防的抗病毒剂，并且作为逆转录病毒特别是HIV的病毒感染的治疗。 还描述了等温线和抑制剂的合成过程。
-
公开(公告)号：US20070259087A1
公开(公告)日：2007-11-08
申请号：US10560269
申请日：2004-06-10
IPC分类号： C07K14/00 , A01H5/00 , A23K1/17 , C07K14/47 , C11D3/00 , C12N15/11 , C07K7/08 , A61K38/16 , A61P31/04
CPC分类号： C11D3/48 , A23K20/174 , A23K20/189 , A23K20/30 , A23K50/00 , A23K50/75 , A23K50/80 , A61K38/00 , C07K7/08 , C07K14/001 , C07K14/47 , C07K14/705 , C11D3/3719 , C11D3/38
摘要： The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有抗微生物活性的多肽和具有编码多肽的核苷酸序列的多核苷酸。 本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。
-
公开(公告)号：US20080213430A1
公开(公告)日：2008-09-04
申请号：US10560260
申请日：2004-06-10
申请人： Dorotea Raventos Segura , Per Holse Mygind , Hans-Henrik Kristensen Hoegenhaug , Alessandro Tossi
发明人： Dorotea Raventos Segura , Per Holse Mygind , Hans-Henrik Kristensen Hoegenhaug , Alessandro Tossi
IPC分类号： A23K1/165 , A23K1/16 , A01H5/00 , C11D3/48 , C12N1/36 , C12P21/02 , C12N1/21 , C12N15/74 , C12N15/11 , C07K14/00
CPC分类号： C11D3/48 , A01N37/46 , A23K20/147 , A23K20/174 , A23K20/189 , A23K20/195 , A23K20/30 , A23K50/00 , A23K50/75 , A23K50/80 , A61K38/00 , C07K14/001 , C07K14/47 , C11D3/3719 , C11D3/38 , Y02A40/818
摘要： The present invention relates to polypeptides having antimicrobial activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有抗微生物活性的多肽和具有编码多肽的核苷酸序列的多核苷酸。 本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及用于产生和使用多肽的方法。
-
5.发明申请Peptidomimetic Inhibitors Of Retroviral Proteases And Their Use As Antivirals 失效逆转录病毒蛋白酶的拟肽抑制剂及其用作抗病毒药物公开(公告)号：US20070207968A1
公开(公告)日：2007-09-06
申请号：US11629720
申请日：2005-06-15
IPC分类号： A61K38/08 , A61K38/06 , A61K38/05 , A61K38/04 , A61K31/401
CPC分类号： C07D207/08 , A61K31/401 , A61K31/405 , C07D207/09
摘要： The patent describes new peptidomimetic inhibitors of retroviral proteases, in particular of human immunodeficiency virus (HIV) protease. These inhibitors comprise as the core structure a new diaminodiol isostere of the dipeptide Phe-Pro having four stereogenic centres. The inhibitors of the invention have been shown to inhibit HIV protease and can therefore be usefully employed as antivirals for post-exposure prophylaxis and as a therapy for viral infections by a retrovirus, in particular HIV. The syntheses processes of the isosteres and inhibitors are also described.
摘要翻译： 该专利描述了逆转录病毒蛋白酶，特别是人类免疫缺陷病毒（HIV）蛋白酶的新型肽模拟抑制剂。 这些抑制剂包含作为核心结构的具有四个立体中心的二肽Phe-Pro的新的二氨基二醇异构体。 已经显示本发明的抑制剂抑制HIV蛋白酶，因此可以有用地用作暴露后预防的抗病毒剂，并且作为逆转录病毒特别是HIV的病毒感染的治疗剂。 还描述了等温线和抑制剂的合成过程。
-
-
-
-
搜索结果
5 条记录 (耗时 0.011 秒)
