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    SCREENING OF DRUG FOR ATTENTION DEFICIT HYPERACTIVE DISORDER BY USING GIT1 KNOCK-OUT MICE AS A NOVEL ADHD MOUSE MODEL
    1.
    发明申请
    SCREENING OF DRUG FOR ATTENTION DEFICIT HYPERACTIVE DISORDER BY USING GIT1 KNOCK-OUT MICE AS A NOVEL ADHD MOUSE MODEL 有权
    通过使用GIT1 KNOCK-OUT MICE作为新的ADHD鼠标模型来注意缺陷性高血压疾病的药物

    公开(公告)号：US20130061338A1

    公开(公告)日：2013-03-07

    申请号：US13446789

    申请日：2012-04-13

    Applicant: Eunjoon KIM ,  Changwon KANG ,  Won MAH ,  Hyejung WON ,  Eun-Kyoung HAHM ,  EUNJIN KIM

    Inventor： Eunjoon KIM ,  Changwon KANG ,  Won MAH ,  Hyejung WON ,  Eun-Kyoung HAHM ,  EUNJIN KIM

    IPC: A61K49/00 ,  A01K67/027

    CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

    Abstract: Provided is a method of using any mammal except humans, in particular, a mammal as an attention deficit hyperactivity disorder model, wherein genes of G protein-coupled receptor kinase interacting protein 1 (GIT1) as a neuronal synapse protein in the brain are knocked out from the mammal. In addition, disclosed is analysis of GIT1 knock-out mice in aspects of molecular biology, cellular biology, electrical biology and animal behavior and, more particularly, a screening method of novel drug, wherein excessive behavior as an attention deficit hyperactive disorder as well as recovery of theta wave in the frontal lobe are observed by administering a candidate material of the drug, thereby inducing recovery of the attention deficit hyperactivity disorder.

    Abstract translation: 本发明提供了除人以外的任何哺乳动物，特别是哺乳动物作为注意缺陷多动障碍模型的方法，其中G蛋白偶联受体激酶相互作用蛋白1（GIT1）作为脑中神经元突触蛋白的基因被敲除 从哺乳动物。 另外，公开了分子生物学，细胞生物学，电学生物学和动物学行为方面对GIT1敲除小鼠的分析，更具体地说，是新药的筛选方法，其中作为注意缺陷多动障碍的过度行为以及 通过施用药物的候选物质来观察额叶中θ波的恢复，从而诱导注意缺陷多动障碍的恢复。

    Screening of drug for attention deficit hyperactive disorder by using GIT1 knock-out mice as a novel ADHD mouse model
    2.
    发明授权
    Screening of drug for attention deficit hyperactive disorder by using GIT1 knock-out mice as a novel ADHD mouse model 有权
    通过使用GIT1敲除小鼠作为新型ADHD小鼠模型筛选注意缺陷多动障碍药物

    公开(公告)号：US08552253B2

    公开(公告)日：2013-10-08

    申请号：US13446789

    申请日：2012-04-13

    Applicant: Eunjoon Kim ,  Changwon Kang ,  Won Mah ,  Hyejung Won ,  Eun-Kyoung Hahm ,  Eunjin Kim

    Inventor： Eunjoon Kim ,  Changwon Kang ,  Won Mah ,  Hyejung Won ,  Eun-Kyoung Hahm ,  Eunjin Kim

    IPC: G01N33/00 ,  A01K67/027

    CPC classification number: A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356

    Abstract: Provided is a method of using any mammal except humans, in particular, a mammal as an attention deficit hyperactivity disorder model, wherein genes of G protein-coupled receptor kinase interacting protein 1 (GIT1) as a neuronal synapse protein in the brain are knocked out from the mammal. In addition, disclosed is analysis of GIT1 knock-out mice in aspects of molecular biology, cellular biology, electrical biology and animal behavior and, more particularly, a screening method of novel drug, wherein excessive behavior as an attention deficit hyperactive disorder as well as recovery of theta wave in the frontal lobe are observed by administering a candidate material of the drug, thereby inducing recovery of the attention deficit hyperactivity disorder.

    Abstract translation: 本发明提供了除人以外的任何哺乳动物，特别是哺乳动物作为注意缺陷多动障碍模型的方法，其中G蛋白偶联受体激酶相互作用蛋白1（GIT1）作为脑中神经元突触蛋白的基因被敲除 从哺乳动物。 另外，公开了分子生物学，细胞生物学，电学生物学和动物学行为方面对GIT1敲除小鼠的分析，更具体地说，是新药的筛选方法，其中作为注意缺陷多动障碍的过度行为以及 通过施用药物的候选物质来观察额叶中θ波的恢复，从而诱导注意缺陷多动障碍的恢复。

    COMPOSITION, KIT, AND METHOD FOR DIAGNOSING ADHD RISK
    3.
    发明申请
    COMPOSITION, KIT, AND METHOD FOR DIAGNOSING ADHD RISK 审中-公开
    用于诊断ADHD风险的组合物，套件和方法

    公开(公告)号：US20130072391A1

    公开(公告)日：2013-03-21

    申请号：US13446711

    申请日：2012-04-13

    Applicant: Changwon KANG ,  Eunjoon KIM ,  Jae-Won Kim ,  Eunjin KIM ,  Hyejung WON ,  Won MAH ,  Soo-Churl CHO

    Inventor： Changwon KANG ,  Eunjoon KIM ,  Jae-Won Kim ,  Eunjin KIM ,  Hyejung WON ,  Won MAH ,  Soo-Churl CHO

    IPC: C40B30/04 ,  C40B40/06 ,  C07H21/04 ,  G01N21/64

    CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  G01N21/76

    Abstract: The following disclosure relates to a technology of genotyping a particular single nucleotide polymorphism (SNP) having significant association with attention deficit hyperactivity disorder (ADHD) and using the SNP genotypes for predicting the risk of ADHD. The present invention relates to providing a method of predicting ADHD risk by identifying the nucleotide of rs5508181 SNP in GIT1, which is C or T at the 24926101st residue on human chromosome 17, and a linkage disequilibrium block harboring rs5508181. Further, the present invention relates to a composition for diagnosing ADHD risk, including a probe for detecting the SNP or a primer for amplifying the chromosomal region, and a diagnosing kit having the probe immobilized on a surface thereof. Therefore, the method, the composition and the kit for diagnosing ADHD risk according to the following disclosure are useful technologies that can conveniently classify risk groups for ADHD at high sensitivity.

    Abstract translation: 以下公开内容涉及与注意缺陷多动障碍（ADHD）具有显着相关性并使用SNP基因型来预测ADHD风险的特定单核苷酸多态性（SNP）进行基因分型的技术。 本发明涉及通过鉴定GIT1中rs5508181 SNP的核苷酸，即在17号染色​​体上的第24926101位残基处的C或T以及含有rs5508181的连锁不平衡块来提供预测ADHD风险的方法。 此外，本发明涉及用于诊断ADHD风险的组合物，包括用于检测SNP的探针或用于扩增染色体区域的引物，以及具有固定在其表面上的探针的诊断试剂盒。 因此，根据以下公开的方法，组合物和用于诊断ADHD风险的试剂盒是可以以高灵敏度方便地分类ADHD风险组的有用技术。

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