-
1.发明授权6-aryl/heteroalkyloxy benzothiazole and benzimidazole derivatives, method for preparing same, application thereof as drugs, pharmaceutical compositions and novel use in particular as C-MET inhibitors 失效6-芳基/杂烷氧基苯并噻唑和苯并咪唑衍生物，其制备方法，作为药物的用途，药物组合物和特别用作C-MET抑制剂的新用途公开(公告)号：US08188078B2
公开(公告)日：2012-05-29
申请号：US12761973
申请日：2010-04-16
Applicant: Conception Nemecek , Sylvie Wentzler
Inventor： Conception Nemecek , Sylvie Wentzler
IPC: A61K31/535 , C07D417/12 , C07D277/82
CPC classification number: C07D235/30 , C07D235/32 , C07D277/82 , C07D417/12
Abstract: The disclosure relates to compounds of formula (I): wherein A, W, R, R5, and R6 are as defined in the disclosure, or a salt thereof, and to their use as drugs, in particular as c-Met inhibitors.
Abstract translation: 本公开涉及式（I）的化合物：其中A，W，R，R 5和R 6如本公开内容中所定义，或其盐，以及它们作为药物，特别是作为c-Met抑制剂的用途。
-
![NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS](/abs-image/US/2011/10/20/US20110257171A1/abs.jpg.150x150.jpg)
2.发明申请NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS 审中-公开新型咪唑并[1,2-A]吡啶衍生物，其制备方法，作为药物，药物组合物和特别用作抑制剂的新用途公开(公告)号：US20110257171A1
公开(公告)日：2011-10-20
申请号：US13003604
申请日：2009-07-16
Applicant: Dominique Damour , Conception Nemecek , Patrick Nemecek , Sylvie Wentzler
Inventor： Dominique Damour , Conception Nemecek , Patrick Nemecek , Sylvie Wentzler
IPC: A61K31/437 , A61P9/00 , A61P7/04 , A61P3/00 , A61P37/08 , A61P11/06 , A61P7/02 , A61P25/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P3/10 , A61P21/00 , A61P35/00 , A61P35/04 , C07D413/14 , A61K31/5377 , C07D471/04
CPC classification number: C07D277/82 , C07D471/04
Abstract: The invention relates to the novel products of formula (I): in which: Ra is H, Hal, aryl or heteroaryl, which are optionally substituted; Rb is H, Rc, —COORc-CO-Rc or —CO—NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
Abstract translation: 本发明涉及式（I）的新产物：其中：R a是任选取代的H，Hal，芳基或杂芳基; Rb是H，Rc，-COORc-CO-Rc或-CO-NRcRd; 其中R c是烷基，环烷基，杂环烷基，芳基和杂芳基，全部被取代; Rd为H，烷基或环烷基; 这些产品是所有异构体形式和盐，作为药物，特别是作为MET抑制剂。
-
3.发明授权Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US07968566B2
公开(公告)日：2011-06-28
申请号：US12410135
申请日：2009-03-24
Applicant: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
Inventor： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC: C07D401/14 , A61K31/437
CPC classification number: C07D471/04
Abstract: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
-
4.发明授权Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途公开(公告)号：US07759379B2
公开(公告)日：2010-07-20
申请号：US11627518
申请日：2007-01-26
Applicant: Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
Inventor： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
IPC: C07D239/02 , A61K31/505 , A61P43/00
CPC classification number: C07D403/04
Abstract: The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
Abstract translation: 本发明涉及式（I）化合物：其中R1，R2，L1，X，R3，A，R4，R4'，R4“，R4”'，R5，Y和L2如本文所定义， 作为蛋白激酶抑制剂的用途，以及治疗包括其施用的疾病的方法。
-
5.发明申请Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效新型吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途公开(公告)号：US20070093480A1
公开(公告)日：2007-04-26
申请号：US11541051
申请日：2006-09-29
Applicant: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
Inventor： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger
IPC: A61K31/5377 , C07D471/02 , A61K31/4745
CPC classification number: C07D471/04
Abstract: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
-
Patent Agency Ranking
公开(公告)号：US07148215B2
公开(公告)日：2006-12-12
申请号：US10803566
申请日：2004-03-18
Applicant: Andrew James Ratcliffe , Roger John Aitchison Walsh , Tahir Nadeem Majid , Sukanthini Thurairatnam , Shelley Amendola , David John Aldous , John Edward Souness , Conception Nemecek , Sylvie Wentzler , Corinne Venot
Inventor： Andrew James Ratcliffe , Roger John Aitchison Walsh , Tahir Nadeem Majid , Sukanthini Thurairatnam , Shelley Amendola , David John Aldous , John Edward Souness , Conception Nemecek , Sylvie Wentzler , Corinne Venot
CPC classification number: A61K31/495 , C07D487/04 , Y02A50/411
Abstract: The present invention concerns compounds of general formula (I): in which the substituents are as described herein.
Abstract translation: 本发明涉及通式（I）的化合物：其中取代基如本文所述。
-
7.发明授权2-imino-3-alkylbenzothiazoline derivatives bearing a heterocyclic substituent on the alkyl group, their preparation and medicinal products containing them. 失效在烷基上带有杂环取代基的2-亚氨基-3-烷基苯并噻唑啉衍生物及其制备物和含有它们的药用产品。
公开(公告)号：US5260297A
公开(公告)日：1993-11-09
申请号：US815220
申请日：1991-12-31
Applicant: Patrick Jimonet , Claude Gueremy , Joseph Le Blevec , Conception Nemecek
Inventor： Patrick Jimonet , Claude Gueremy , Joseph Le Blevec , Conception Nemecek
IPC: C07D277/82 , C07D417/06 , C07D417/12 , A61K31/44 , A61K31/445 , A61K31/495
CPC classification number: C07D417/06 , C07D277/82 , C07D417/12
Abstract: Compounds of formula: ##STR1## in which R.sub.1 represents a substituted 1-piperazinyl, substituted 1,2,3,6-tetrahydro-1-pyridyl or substituted piperidino radical, R.sub.2 represents a polyfluoroalkoxy or a polyfluoroalkyl radical and n is equal to 2 or 3, the salts of these compounds with an acid, processes for preparing them and medicinal products containing them.
Abstract translation: 其中R1表示取代的1-哌嗪基，取代的1,2,3,6-四氢-1-吡啶基或取代的哌啶子基的式：其中R 2表示多氟烷氧基或多氟烷基，n等于2 或3，这些化合物与酸的盐，其制备方法和含有它们的药用产品。
-
8.发明申请DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS 审中-公开6-（6-NH-取代的三唑基亚氨基 - 磺酰基）苯并噻唑和苯并咪唑的衍生物，其制备方法及其作为药物的用途，以及作为抑制剂的用途公开(公告)号：US20120040987A1
公开(公告)日：2012-02-16
申请号：US13147297
申请日：2010-02-04
Applicant: Eric Bacque , Conception Nemecek , Antonio Ugolini , Sylvie Wentzler
Inventor： Eric Bacque , Conception Nemecek , Antonio Ugolini , Sylvie Wentzler
IPC: A61K31/5025 , C07D277/82 , A61P35/00 , A61P21/00 , A61P3/10 , A61P17/06 , A61P27/02 , A61P19/02 , A61P25/00 , A61P11/06 , A61P7/02 , A61P3/00 , A61P37/08 , A61P35/04 , C07D487/04
CPC classification number: C07D277/82 , C07D487/04
Abstract: The invention relates to novel products of the formula (I) where: (II) is a single or double bond; Rb is a hydrogen or fluorine atom; Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical; X is S, SO, or SO2; A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; —O— (CH2)n-phenyl with n=1 to 4; or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH; all of said radicals being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
Abstract translation: 本发明涉及式（I）的新产物，其中：（II）是单键或双键; Rb是氢或氟原子; R a是NH-R c基团，其中R c是任选取代的杂环烷基，芳基，杂芳基或 - 烷基环烷基; X是S，SO或SO 2; A是NH或S; W是H，烷基或COR，其中R是环烷基; 烷基; 烷氧基 O-苯基; -O-（CH 2）n - 苯基，n = 1〜4; 或NR1R2，其中R1是H或alk，R2是H，环烷基或烷基; 或R 1，R 2与任选地含有O，S，N和/或NH的N一起形成一个循环; 所有这些基团任选被取代; 其中所述产物可以是任何异构体或盐形式，并且可以用作药物，特别是作为MET抑制剂。
-
9.发明申请NOVEL TRIAZOLO(4,3-A)PYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE, IN PARTICULAR AS MET INHIBITORS 审中-公开新型三唑（4,3-A）吡啶衍生物，其制备方法，作为药物，药物组合物和新药使用，特别是作为抑制剂公开(公告)号：US20110263594A1
公开(公告)日：2011-10-27
申请号：US13054663
申请日：2009-07-16
Applicant: Eric Bacque , Dominique Damour , Conception Nemecek , Patrick Nemecek , Sylvie Wentzler
Inventor： Eric Bacque , Dominique Damour , Conception Nemecek , Patrick Nemecek , Sylvie Wentzler
IPC: A61K31/437 , C07D413/14 , A61K31/5377 , A61P9/00 , A61P7/04 , A61P3/00 , A61P37/00 , A61P11/06 , A61P7/02 , A61P25/00 , A61P9/10 , A61P17/06 , A61P29/00 , A61P3/10 , A61P21/00 , A61P35/00 , A61P35/04 , C07D471/04
CPC classification number: A61K31/428 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D471/04
Abstract: The invention relates to the novel products of formula (I): in which: Ra represents H, Hal, aryl or heteroaryl, which is optionally substituted; Rb represents H, Rc, —COORc-CO-Rc or —CO—NRcRd; where Rc represents alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd represents H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
Abstract translation: 本发明涉及式（I）的新产物：其中：R a表示任选取代的H，Hal，芳基或杂芳基; Rb表示H，Rc，-COORc-CO-Rc或-CO-NRcRd; 其中R c代表烷基，环烷基，杂环烷基，芳基和杂芳基，全部任意取代; Rd表示H，烷基或环烷基; 这些产品是所有异构体形式和盐，作为药物，特别是作为MET抑制剂。
-
10.发明申请NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS 审中-公开新型双嘧啶衍生物，其作为激酶抑制剂的制备和药物使用公开(公告)号：US20100256141A1
公开(公告)日：2010-10-07
申请号：US12821371
申请日：2010-06-23
Applicant: Conception NEMECEK , William A. METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
Inventor： Conception NEMECEK , William A. METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
IPC: A61K31/5377 , C07D471/04 , A61K31/437 , C07D413/14 , C07D403/14 , A61K31/497 , A61P35/00 , A61P3/00 , A61P11/06 , A61P37/08 , A61P7/02 , A61P25/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P27/02 , C12N9/99
CPC classification number: C07D519/00
Abstract: Disclosed are compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
Abstract translation: 公开了式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
-
-
-
-
-
-
-
-
-
Search Results
37
records
(took 0.036 seconds)
