公开(公告)号：US20070042001A1

公开(公告)日：2007-02-22

申请号：US11505694

申请日：2006-08-16

Applicant: Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

Inventor： Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

IPC: A61K39/145 ,  C07H21/04 ,  C12N7/00 ,  C12N5/06 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2800/105

Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.

Abstract translation: 本发明提供流感蛋白，包括亚基蛋白和免疫原性组合物，其可以使用或不含佐剂，作为用于在动物模型和人类中防止流感感染的疫苗。 转化的昆虫细胞在其基因组中含有合适的表达盒的集成拷贝来表达重组蛋白质。 本发明使用黑腹果蝇表达系统提供具有天然样构象的高产量的重组亚基蛋白。

公开(公告)号：US20100116592A1

公开(公告)日：2010-05-13

申请号：US12269016

申请日：2008-11-11

Applicant: Jeffrey David Clements ,  Rodney Wayne Rosenthal

Inventor： Jeffrey David Clements ,  Rodney Wayne Rosenthal

IPC: E06C7/04

CPC classification number: E06C7/44 ,  E06C1/39 ,  E06C7/46

Abstract: A stepladder with four individually adjustable, self-locking rails so that the ladder can be placed on uneven terrain then safely adjusted to maintain level orientation. The ladder rails will consist of four pairs of outer and inner rails. Each outer and inner rail pair is designed with profiles that when brought together will lock into one another providing stability yet minimal friction. Each inner rail is held in place by a spring-loaded lever with attached hooks. The spring forces the hooks to be engaged with an adjustment bracket that is fixed to the outer rail. A foot will be fixed to the bottom of each inner rail. Each foot will have arched surfaces along 2 perpendicular horizontal axes so that consistent surface area contact is maintained with the ground regardless of the angle of the ground. On a level surface, when the ladder is in an un-adjusted state, the four inner rails are designed to be extended with respect to the outer rails providing equal distance between each step and reducing weight and production costs.

Abstract translation: 梯子具有四个可单独调节的自锁导轨，使梯子可以放置在不平坦的地形上，然后安全调整以保持水平方向。 梯子轨道将由四对外轨和内轨组成。 每个外轨道和内轨对都设计有轮廓，当组合在一起时将彼此锁定，从而提供稳定性，但最小的摩擦力。 每个内轨通过带有连接钩的弹簧加载杆固定在适当位置。 弹簧迫使钩与固定在外轨上的调节支架接合。 一只脚固定在每个内轨的底部。 每个脚将沿着两个垂直的水平轴线具有拱形表面，以便与地面的角度保持一致的表面积接触。 在水平表面上，当梯子处于未调整状态时，四个内轨道被设计成相对于外轨道延伸，在每个台阶之间提供相等的距离，并减轻重量和生产成本。

公开(公告)号：US20090151297A1

公开(公告)日：2009-06-18

申请号：US12093451

申请日：2006-11-10

Applicant: David Clements ,  Alan Benson

Inventor： David Clements ,  Alan Benson

IPC: E04B1/00 ,  E04G21/14 ,  E04B1/38

CPC classification number: H02B1/50

Abstract: A method for attaching a surface mountable unit to a ground surface, said method comprising (i) fixing a foundation frame, an upper portion of which is attachable to said surface mountable unit to the ground surface, and (ii) attaching the surface mountable unit to the upper portion of the foundation frame. Systems comprising combinations of foundation frames and surface mountable units and elements for use therein are also described and claimed.

Abstract translation: 一种用于将表面可安装单元附接到地面的方法，所述方法包括（i）将基部框架的上部固定到所述表面安装单元到地面上，以及（ii）将所述表面安装单元 到基础框架的上部。 还描述并要求保护包括基础框架和表面安装单元以及用于其中的元件的组合的系统。

公开(公告)号：US5960588A

公开(公告)日：1999-10-05

申请号：US822390

申请日：1997-03-20

Applicant: Georg Wurm ,  David Clements

Inventor： Georg Wurm ,  David Clements

IPC: B60J5/04 ,  E05F11/52 ,  E05F11/48

CPC classification number: B60J5/0416 ,  E05F11/488 ,  E05Y2201/684 ,  E05Y2201/702 ,  E05Y2600/20 ,  E05Y2900/55

Abstract: Apparatus for adjusting a frameless window pane moved by a cable window lifter in an automobile. The apparatus includes a first guide rail which has an unlocked and a locked state, and a second guide rail. The first guide rail is freely movable to a limited degree in the unlocked state and fixed in the locked state. A window pane is connected between the first guide rail and the second guide rail such that movement of the second guide rail causes the first guide rail to move when in its unlocked state. A bolt is provided for moving the second guide rail and for locking the first guide rail.

Abstract translation: 用于调节由汽车中的电缆窗升降机移动的无框窗玻璃的装置。 该装置包括具有解锁和锁定状态的第一导轨和第二导轨。 第一导轨可在解锁状态下自由移动到有限的程度并固定在锁定状态。 窗玻璃连接在第一导轨和第二导轨之间，使得当处于其解锁状态时，第二导轨的运动导致第一导轨移动。 提供用于移动第二导轨并锁定第一导轨的螺栓。

公开(公告)号：US2694615A

公开(公告)日：1954-11-16

申请号：US21903351

申请日：1951-04-03

Applicant: DAVID CLEMENTS

Inventor： DAVID CLEMENTS

IPC: G01D15/24

CPC classification number: G01D15/24

公开(公告)号：US09271896B2

公开(公告)日：2016-03-01

申请号：US14311289

申请日：2014-06-21

Applicant: David Clements

Inventor： David Clements

IPC: A61M5/00 ,  A61J1/18 ,  A61B19/00

CPC classification number: A61J1/18 ,  A61B90/90 ,  A61B90/92 ,  A61B90/94 ,  A61B90/96 ,  A61J1/00 ,  A61J1/035 ,  A61J1/10 ,  A61J2205/20 ,  A61J2205/50 ,  A61M5/31525 ,  A61M2005/3126

Abstract: An apparatus having a container comprising a volume. The volume is configured to retain a single dose of a medication appropriate for a specific classification of a weight of a patient. A first indicia is disposed on an exterior surface of the container. The first indicia indicates a type of the medication. A second indicia is disposed on the exterior surface. The second indicia indicates the specific classification, wherein the container, pre-packaged with the single dose, is appropriate for a single use dosing of the patient having the specific classification.

Abstract translation: 一种具有容器的装置，包括容积。 体积被配置为保留适合于患者重量的特定分类的单剂量的药物。 第一标记设置在容器的外表面上。 第一个标记表示一种药物。 第二标记设置在外表面上。 第二标记表示具体分类，其中用单次剂量预先包装的容器适合于具有特定分类的患者的单次使用剂量。

公开(公告)号：US20150366757A1

公开(公告)日：2015-12-24

申请号：US14311289

申请日：2014-06-21

Applicant: David Clements

Inventor： David Clements

IPC: A61J1/18 ,  A61B19/00

CPC classification number: A61J1/18 ,  A61B90/90 ,  A61B90/92 ,  A61B90/94 ,  A61B90/96 ,  A61J1/00 ,  A61J1/035 ,  A61J1/10 ,  A61J2205/20 ,  A61J2205/50 ,  A61M5/31525 ,  A61M2005/3126

Abstract: An apparatus comprises a container comprising a volume. The volume is configured to retain a single dose of a medication appropriate for a specific classification of a weight of a patient. A first indicia is disposed on an exterior surface of the container. The first indicia indicates a type of the medication. A second indicia is disposed on the exterior surface. The second indicia indicates the specific classification, wherein the container, pre-packaged with the single dose, is appropriate for a single use dosing of the patient having the specific classification.

Abstract translation: 一种装置包括容器，其包括容积。 体积被配置为保留适合于患者重量的特定分类的单剂量的药物。 第一标记设置在容器的外表面上。 第一个标记表示一种药物。 第二标记设置在外表面上。 第二标记表示具体分类，其中用单次剂量预先包装的容器适合于具有特定分类的患者的单次使用剂量。

公开(公告)号：US20070042002A1

公开(公告)日：2007-02-22

申请号：US11506991

申请日：2006-08-16

Applicant: Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

Inventor： Carolyn Weeks-Levy ,  David Clements ,  Steven Ogata

IPC: A61K39/145 ,  C07H21/04 ,  C12N7/00 ,  C12N5/06 ,  C12N15/86 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2800/105

Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.

公开(公告)号：US6136561A

公开(公告)日：2000-10-24

申请号：US937195

申请日：1997-09-25

Applicant: John Ivy ,  Eilen Nakano ,  David Clements

Inventor： John Ivy ,  Eilen Nakano ,  David Clements

IPC: A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/09

CPC classification number: C07K14/005 ,  C07K16/1081 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C12N2770/24122 ,  G01N2333/18

Abstract: The Flaviviridae comprise a number of medically important pathogens that cause significant morbidity in humans including the dengue (DEN) virus, Japanese encephalitis (JE) virus, tick-borne encephalitis virus (TBE), and yellow fever virus (YF). Flaviviruses are generally transmitted to vertebrates by chronically infected mosquito or tick vectors. The viral particle which is enveloped by host cell membranes, comprises a single positive strand genomic RNA and the structural capsid (CA), membrane (M), and envelope (E) proteins. The E and M proteins are found on the surface of the virion where they are anchored in the membrane. Mature E is glycosylated and contains functional domains responsible for cell surface attachment and intraendosomal fusion activities. Problems have arisen in the art with respect to producing recombinant forms of the E glycoprotein that retain their native configuration and attendant properties associated therewith (i.e., ability to induce neutralizing antibody responses). To date, recombinantly produced E glycoproteins have suffered from a number of limitations including improper glycosylation, folding, and disulfide bond formation. The claimed invention has addressed these concerns by providing secreted recombinant forms of the E glycoprotein that are highly immunogenic and appear to retain their native configuration. Carboxy-terminally truncated forms of E containing the amino terminal 395 amino acids and a suitable secretion signal sequence were generated in Drosophila melanogaster Schneider cell lines. The recombinant proteins produced by this expression system should prove useful, inter alia, as immunogens and diagnostic reagents.

Abstract translation: 黄病毒科包括许多在医学上重要的病原体，其引起人类重大的发病率，包括登革热（DEN）病毒，日本脑炎（JE）病毒，蜱传脑炎病毒（TBE）和黄热病病毒（YF）。 黄病毒一般通过慢性感染的蚊子或蜱载体传播给脊椎动物。 由宿主细胞膜包围的病毒颗粒包含单个正链基因组RNA和结构衣壳（CA），膜（M）和包膜（E）蛋白。 E和M蛋白存在于病毒粒子的表面，它们被锚定在膜中。 成熟的E被糖基化并且包含负责细胞表面附着和体内融合活性的功能结构域。 关于生产重组形式的E糖蛋白，其保留其天然构型和与其相关的伴随性质（即，诱导中和抗体应答的能力）方面出现了问题。 迄今为止，重组产生的E糖蛋白已经受到许多限制，包括不正确的糖基化，折叠和二硫键形成。 所要求保护的发明通过提供高度免疫原性并且看起来保持其天然构型的E糖蛋白的分泌重组形式来解决这些问题。 在黑腹果蝇施耐德细胞系中产生含有氨基末端395个氨基酸和合适的分泌信号序列的E的羧基末端截短形式。 由该表达系统产生的重组蛋白尤其应用于免疫原和诊断试剂。

公开(公告)号：US08462519B2

公开(公告)日：2013-06-11

申请号：US12781307

申请日：2010-05-17

Applicant: Esen Bayar ,  Steven David Clements ,  Graham James Quintal

Inventor： Esen Bayar ,  Steven David Clements ,  Graham James Quintal

IPC: H05K9/00

CPC classification number: H05K9/0022 ,  Y10T29/49 ,  Y10T29/49826

Abstract: There is disclosed a method of shielding a circuit board, a circuit board, an electromagnetic shield and a method of manufacturing an electromagnetic shield. In an aspect, the method comprises placing a first electromagnetic shield over a first area of the circuit board and placing a second electromagnetic shield over a second area of the circuit board. At least one of the electromagnetic shields has at least one projection therefrom that contacts and makes electrical connection with a surface of the other electromagnetic shield when the shields are placed on the circuit board.

Abstract translation: 公开了一种屏蔽电路板，电路板，电磁屏蔽以及制造电磁屏蔽的方法。 一方面，该方法包括将第一电磁屏蔽物放置在电路板的第一区域上，并将第二电磁屏蔽物放置在电路板的第二区域上。 当屏蔽件被放置在电路板上时，电磁屏蔽中的至少一个具有至少一个突起，其与另一个电磁屏蔽的表面接触并形成电连接。