公开(公告)号：US20080269119A1

公开(公告)日：2008-10-30

申请号：US11660135

申请日：2005-08-12

申请人： May Griffith ,  David J. Carlsson ,  Fengfu Li ,  Yuwen Liu ,  Mehrdad Rafat

发明人： May Griffith ,  David J. Carlsson ,  Fengfu Li ,  Yuwen Liu ,  Mehrdad Rafat

IPC分类号： A61K38/18 ,  A61K47/42 ,  A61K38/02 ,  A61P27/02 ,  A61K38/08 ,  A61K38/06

CPC分类号： A61L27/24 ,  A61F9/0017 ,  A61K38/39 ,  A61L27/20 ,  A61L27/52 ,  A61L2430/16

摘要： Devices, methods, and compositions for improving vision or treating diseases, disorders or injury of the eye are described. Ophthalmic devices, such as corneal onlays, corneal inlays, and full-thickness corneal implants, are made of a material that is effective in facilitating nerve growth through or over the device. The material may include an amount of collagen greater than 1% (w/w), such as between about 10% (w/w) and about 30% (w/w). The material may include collagen polymers and/or a second biopolymer or water-soluble synthetic polymer cross-linked using EDC/NHS chemistry. The material may additionally comprise a synthetic polymer. The devices are placed into an eye to correct or improve the vision of an individual or to treat a disease, disorder or injury of an eye of an individual.

摘要翻译： 描述了用于改善视力或治疗眼睛疾病，障碍或损伤的装置，方法和组合物。 眼科装置，例如角膜镶嵌，角膜镶嵌和全厚度角膜植入物，由有助于通过或超过装置的神经生长有效的材料制成。 该材料可以包括大于1％（w / w）的胶原，例如约10％（w / w）至约30％（w / w）的胶原。 该材料可以包括使用EDC / NHS化学交联的胶原聚合物和/或第二生物聚合物或水溶性合成聚合物。 该材料可另外包含合成聚合物。 将装置放置在眼睛中以校正或改善个体的视力或治疗个体的眼睛的疾病，障碍或损伤。

公开(公告)号：US4048367A

公开(公告)日：1977-09-13

申请号：US554990

申请日：1975-03-03

申请人： David J. Carlsson ,  Tony Suprunchuk ,  David M. Wiles

发明人： David J. Carlsson ,  Tony Suprunchuk ,  David M. Wiles

IPC分类号： C08J7/06 ,  D06M10/00 ,  B05D1/18 ,  B05D3/14 ,  B32B27/02 ,  B32B27/16

CPC分类号： D06M10/001 ,  C08J7/065 ,  Y10T428/265 ,  Y10T428/2967 ,  Y10T428/2969

摘要： Articles formed from polymers which are susceptible to degradative attack by ultraviolet radiation are stabilized by the application of a thin continuous layer of an energy transfer agent, which agent does not significantly absorb radiation in the ultraviolet region of the spectrum. The energy transfer agent is a substituted phenol, and the agent is used in amounts of at most 0.4%, by weight, based on the demonstrate prolonged resistance to ultraviolet degradation.

摘要翻译： 由易受紫外线辐射降解侵袭的聚合物形成的物品通过施加能量转移剂的薄连续层来稳定，该载体不会显着吸收光谱的紫外区域中的辐射。 能量转移剂是取代的苯酚，并且基于证明延长的耐紫外线降解性，该试剂的用量至多为0.4重量％。