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8 条记录 (耗时 0.021 秒)

    Corneal implant and uses thereof
    3.
    发明授权
    Corneal implant and uses thereof 失效
    角膜植入物及其用途

    公开(公告)号：US07476398B1

    公开(公告)日：2009-01-13

    申请号：US10606796

    申请日：2003-06-27

    申请人： Charles J. Doillon ,  May Griffith ,  Fengfu Li ,  Shigeto Shimmura

    发明人： Charles J. Doillon ,  May Griffith ,  Fengfu Li ,  Shigeto Shimmura

    IPC分类号： A61F2/00 ,  A61F2/14

    CPC分类号： A61F2/142 ,  A61L27/26 ,  C08L33/26

    摘要： A membrane for corneal implant or keratoprosthesis comprising a biological polymer and a polyacrylamide is described. The mixture of both polymers produces a hydrogel that becomes a transparent film or membrane upon drying. The resulting device and tissue engineered implants are useful for biomedical applications of the cornea, such as tissue repair and transplantation.

    摘要翻译： 描述了包含生物聚合物和聚丙烯酰胺的角膜植入物或角膜假体的膜。 两种聚合物的混合物产生水凝胶，其在干燥时变成透明膜或膜。 所得到的装置和组织工程植入物可用于角膜的生物医学应用，例如组织修复和移植。

    Vision enhancing ophthalmic devices and related methods and compositions
    4.
    发明申请
    Vision enhancing ophthalmic devices and related methods and compositions 审中-公开
    视力增强眼科装置及相关方法和组合物

    公开(公告)号：US20060134170A1

    公开(公告)日：2006-06-22

    申请号：US11203685

    申请日：2005-08-12

    申请人： May Griffith ,  David Carlsson ,  Fengfu Li ,  Yuwen Liu ,  J.Christopher Marmo ,  Mehrdad Asmanrafat

    发明人： May Griffith ,  David Carlsson ,  Fengfu Li ,  Yuwen Liu ,  J.Christopher Marmo ,  Mehrdad Asmanrafat

    IPC分类号： A61F2/14 ,  A61K38/39

    CPC分类号： A61L27/24 ,  A61F9/0017 ,  A61K38/39 ,  A61L27/20 ,  A61L27/52 ,  A61L2430/16

    摘要： Devices, methods, and compositions for improving vision or treating diseases, disorders or injury of the eye are described. Ophthalmic devices, such as corneal onlays, corneal inlays, and full-thickness corneal implants, are made of a material that is effective in facilitating nerve growth through or over the device. The material may include an amount of collagen greater than 1% (w/w), such as between about 10% (w/w) and about 30% (w/w). The material may include collagen polymers and/or a second biopolymer or water-soluble synthetic polymer cross-linked using EDC/NHS chemistry. The material may additionally comprise a synthetic polymer. The devices are placed into an eye to correct or improve the vision of an individual or to treat a disease, disorder or injury of an eye of an individual.

    摘要翻译： 描述了用于改善视力或治疗眼睛疾病，障碍或损伤的装置，方法和组合物。 眼科装置，例如角膜镶嵌，角膜镶嵌和全厚度角膜植入物，由有助于通过或超过装置的神经生长有效的材料制成。 该材料可以包括大于1％（w / w）的胶原，例如约10％（w / w）至约30％（w / w）的胶原。 该材料可以包括使用EDC / NHS化学交联的胶原聚合物和/或第二生物聚合物或水溶性合成聚合物。 该材料可另外包含合成聚合物。 将装置放置在眼睛中以校正或改善个体的视力或治疗个体的眼睛的疾病，障碍或损伤。

    Crosslinked Hydrogels and Related Method of Preparation
    5.
    发明申请
    Crosslinked Hydrogels and Related Method of Preparation 有权
    交联水凝胶及相关制备方法

    公开(公告)号：US20120321585A1

    公开(公告)日：2012-12-20

    申请号：US13499088

    申请日：2010-09-29

    申请人： May Griffith ,  Fengfu Li ,  Jae-Il Ahn

    发明人： May Griffith ,  Fengfu Li ,  Jae-Il Ahn

    IPC分类号： A61K38/39 ,  A61P27/02 ,  C07K14/78

    CPC分类号： A61K9/06 ,  A61K9/0051 ,  A61K31/522 ,  A61K38/39 ,  A61K41/0042 ,  A61K47/42 ,  A61K49/0073 ,  A61L27/24 ,  A61L27/52 ,  A61L2430/16 ,  C08H1/06 ,  C08J3/075 ,  C08J3/24 ,  C08J2300/16 ,  C08J2389/06 ,  C08K5/0025 ,  C08K5/29 ,  C08L89/06

    摘要： The present invention provides a method of manufacturing a hydrogel comprising the step of crosslinking a biopolymer using a carbodiimide crosslinker of Formula I wherein at least one of R1 and R2 is a functional group that is a bulky organic functional group. R1 and R2 can each independently be an optionally substituted saturated or unsaturated functional group selected from the group consisting of an alkyl, a cycloalkyl, a heterocyclic, and an aryl. The bulky organic functional group will slow down the crosslinking reaction of carbodiimide due to the steric effects and/or electronic effects, in comparison to a crosslinking reaction using EDC. Also provided are the hydrogels and ophthalmic devices prepared using the method of the invention and uses thereof.

    摘要翻译： 本发明提供一种制备水凝胶的方法，其包括使用式I的碳二亚胺交联剂交联生物聚合物的步骤，其中R 1和R 2中的至少一个是大体积有机官能团的官能团。 R 1和R 2可各自独立地为选自烷基，环烷基，杂环和芳基的任选取代的饱和或不饱和官能团。 与使用EDC的交联反应相比，体积大的有机官能团将由于空间效应和/或电子效应而减缓碳二亚胺的交联反应。 还提供了使用本发明的方法制备的水凝胶和眼科装置及其用途。

    Ophthalmic Device and Related Methods and Compositions
    7.
    发明申请
    Ophthalmic Device and Related Methods and Compositions 审中-公开
    眼科装置及其相关方法和组合

    公开(公告)号：US20080269119A1

    公开(公告)日：2008-10-30

    申请号：US11660135

    申请日：2005-08-12

    申请人： May Griffith ,  David J. Carlsson ,  Fengfu Li ,  Yuwen Liu ,  Mehrdad Rafat

    发明人： May Griffith ,  David J. Carlsson ,  Fengfu Li ,  Yuwen Liu ,  Mehrdad Rafat

    IPC分类号： A61K38/18 ,  A61K47/42 ,  A61K38/02 ,  A61P27/02 ,  A61K38/08 ,  A61K38/06

    CPC分类号： A61L27/24 ,  A61F9/0017 ,  A61K38/39 ,  A61L27/20 ,  A61L27/52 ,  A61L2430/16

    摘要： Devices, methods, and compositions for improving vision or treating diseases, disorders or injury of the eye are described. Ophthalmic devices, such as corneal onlays, corneal inlays, and full-thickness corneal implants, are made of a material that is effective in facilitating nerve growth through or over the device. The material may include an amount of collagen greater than 1% (w/w), such as between about 10% (w/w) and about 30% (w/w). The material may include collagen polymers and/or a second biopolymer or water-soluble synthetic polymer cross-linked using EDC/NHS chemistry. The material may additionally comprise a synthetic polymer. The devices are placed into an eye to correct or improve the vision of an individual or to treat a disease, disorder or injury of an eye of an individual.

    摘要翻译： 描述了用于改善视力或治疗眼睛疾病，障碍或损伤的装置，方法和组合物。 眼科装置，例如角膜镶嵌，角膜镶嵌和全厚度角膜植入物，由有助于通过或超过装置的神经生长有效的材料制成。 该材料可以包括大于1％（w / w）的胶原，例如约10％（w / w）至约30％（w / w）的胶原。 该材料可以包括使用EDC / NHS化学交联的胶原聚合物和/或第二生物聚合物或水溶性合成聚合物。 该材料可另外包含合成聚合物。 将装置放置在眼睛中以校正或改善个体的视力或治疗个体的眼睛的疾病，障碍或损伤。

    Bio-synthetic matrix and uses thereof
    8.
    发明申请
    Bio-synthetic matrix and uses thereof 审中-公开
    生物合成基质及其用途

    公开(公告)号：US20060246113A1

    公开(公告)日：2006-11-02

    申请号：US11479297

    申请日：2006-06-30

    申请人： May Griffith ,  David Carlsson ,  Fengfu Li

    发明人： May Griffith ,  David Carlsson ,  Fengfu Li

    IPC分类号： A61F2/00

    CPC分类号： A61F2/02 ,  A61F2/10 ,  A61F2/142 ,  A61K35/12 ,  A61K38/08 ,  A61K47/58 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3839 ,  A61L27/44 ,  C08F220/54 ,  C08L33/26

    摘要： A bio-synthetic matrix comprising a hydrogel which is formed by cross-linking a synthetic polymer and a bio-polymer is provided. The matrix is robust, biocompatible and non-cytotoxic and is capable of supporting cell in-growth in vivo. The matrix can be tailored to further comprise one or more bioactive agents. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating upon deposition of the matrix in vivo. Methods of preparing the bio-synthetic matrix and the use of the matrix in vivo for tissue engineering or drug delivery applications are also provided.

    摘要翻译： 提供了包含通过交联合成聚合物和生物聚合物形成的水凝胶的生物合成基质。 该基质是稳健的，生物相容的和非细胞毒性的，并且能够支持体内细胞生长。 可以调整基质以进一步包含一种或多种生物活性剂。 基质还可以包含包封并分散在其中的细胞，其能够在体内沉积基质时增殖。 还提供了制备生物合成基质的方法和体内基质在组织工程或药物递送应用中的应用。