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    Suspension system for heavy and vocational vehicles
    1.
    发明授权
    Suspension system for heavy and vocational vehicles 有权
    重型和职业车辆悬挂系统

    公开(公告)号：US08371596B2

    公开(公告)日：2013-02-12

    申请号：US12778888

    申请日：2010-05-12

    申请人： Marc Johnson ,  Mark Molitor ,  Jeffrey Michael Galla ,  Jason Klein ,  David Roe ,  Daniel R. Dykstra

    发明人： Marc Johnson ,  Mark Molitor ,  Jeffrey Michael Galla ,  Jason Klein ,  David Roe ,  Daniel R. Dykstra

    IPC分类号： B60G9/02 ,  B60G11/64 ,  B60G7/04 ,  B60G21/05

    CPC分类号： B60G11/27 ,  B60G9/003 ,  B60G9/022 ,  B60G11/28 ,  B60G21/0551 ,  B60G2200/314 ,  B60G2200/315 ,  B60G2202/135

    摘要： A vehicle suspension system includes a first trailing arm assembly and a second trailing assembly each including a mounting bracket adapted to be secured to a vehicle frame and a trailing arm member pivotably coupled to the associated mounting bracket and adapted to be operably coupled to an axle member, wherein the trailing arm members each include an aperture extending therein, wherein the aperture has a relatively constant cross-sectional configuration along a depth thereof. The vehicle suspension system further includes a torsional member extending between the first and second trailing arm members and frictionally secured within the apertures thereof, wherein the torsional member has a relatively constant cross-sectional configuration along a length thereof that is received within the apertures of the trailing arms.

    摘要翻译： 车辆悬挂系统包括第一牵引臂组件和第二牵引组件，每个牵引臂组件包括适于固定到车辆框架的安装支架和可枢转地联接到相关联的安装支架的后臂构件，并且适于可操作地联接到轴构件 其中所述尾臂构件各自包括在其中延伸的孔，其中所述孔沿其深度具有相对恒定的横截面构型。 车辆悬架系统还包括在第一和第二牵引臂构件之间延伸并摩擦地固定在其孔内的扭转构件，其中扭转构件具有沿其长度的相对恒定的横截面构造，该横截面构造被容纳在 拖尾臂。

    Method and apparatus for aligning time references when separated by an unreliable data packet network
    3.
    发明授权
    Method and apparatus for aligning time references when separated by an unreliable data packet network 有权
    用于在由不可靠的数据分组网络分离时对准时间基准的方法和装置

    公开(公告)号：US07590151B2

    公开(公告)日：2009-09-15

    申请号：US11054779

    申请日：2005-02-09

    申请人： Vernon Middleton ,  David Roe ,  Paul Rushton ,  David Tonks

    发明人： Vernon Middleton ,  David Roe ,  Paul Rushton ,  David Tonks

    IPC分类号： H04J3/06

    CPC分类号： H04J3/0664 ,  H04J3/0673 ,  H04J3/0682 ,  H04J3/0697

    摘要： A time control mechanism accepts samples of time (true or otherwise) over a network, and enables dynamic compensation for random delays of the network in order to maintain the output of a slave clock that the time control mechanism controls within required bounds relative to the time of a master clock, even when the samples are randomly delayed. In one embodiment, a hardware timestamping method and apparatus is provided. The hardware timestamping method and apparatus is used to achieve the fine resolution required for timestamping both received samples and transmitted requests. In another embodiment, a delay-variation-smoothing method and apparatus is provided. The delay-variation-smoothing method and apparatus allows the time control mechanism to calculate the network delay in order to maintain the slave clock within the required time bounds. Moreover, a method and apparatus is provided that not only compensates for the random delays in the samples but also dynamically adjusts its operations to suit the changing characteristics of the delay path (typically a network).

    摘要翻译： 时间控制机制通过网络接受时间（真实或其他）的采样，并对网络的随机延迟进行动态补偿，以便保持时间控制机制在相对于时间的所需范围内控制的从时钟的输出 的时钟，即使样品随机延迟。 在一个实施例中，提供了硬件时间戳方法和装置。 硬件时间戳方法和装置用于实现对接收到的采样和发送的请求的时间戳所需的精细分辨率。 在另一个实施例中，提供了延迟变化平滑方法和装置。 延迟变化平滑方法和装置允许时间控制机制计算网络延迟，以便将从时钟保持在所需时间范围内。 此外，提供了一种方法和装置，其不仅补偿样本中的随机延迟，而且还动态地调整其操作以适应延迟路径（通常为网络）的变化特性。

    Dopamine D4 receptor ligands
    4.
    发明授权
    Dopamine D4 receptor ligands 失效
    多巴胺D4受体配体

    公开(公告)号：US5976497A

    公开(公告)日：1999-11-02

    申请号：US905546

    申请日：1997-08-04

    申请人： Alfred Pollak ,  Robert Dunn-Dufault ,  David Roe

    发明人： Alfred Pollak ,  Robert Dunn-Dufault ,  David Roe

    IPC分类号： A61K51/04 ,  C07B59/00 ,  C07D471/04 ,  C07F7/22 ,  A61K49/00

    CPC分类号： C07F7/2212 ,  A61K51/0459 ,  C07B59/002 ,  C07D471/04 ,  A61K2123/00 ,  Y02P20/55

    摘要： Described herein are D4 receptor-selective compounds of the formula: ##STR1## wherein R.sup.1 is selected from H and an acid labile protecting group; and R.sup.2 and R.sup.3 are independently selected from H, radioisotopic halo, loweralkoxy and tri(loweralkyl)tin; and salts, solvates or hydrates thereof.Also described is the use of these compounds as pharmaceuticals to treat indications for which a dopamine D4 receptor antagonist is indicated. Radiolabeled compounds are useful particularly to image localization of D4 receptor in the human brain, and can therefore aid in the diagnosis of schizophrenia and other medical conditions in which the D4 receptor is implicated.

    摘要翻译： 本文描述的是下式的D4受体选择性化合物：其中R1选自H和酸不稳定保护基; R2和R3独立地选自H，放射性同位素卤代，低级烷氧基和三（低级烷基）锡; 及其盐，溶剂合物或水合物。 还描述了这些化合物作为药物来治疗指示多巴胺D4受体拮抗剂的适应症的用途。 放射性标记的化合物特别用于人类脑中D4受体的成像定位，因此可以有助于诊断精神分裂症和其他涉及D4受体的医学病症。

    Chemotactic peptide antagonists for imaging sites of inflammation
    7.
    发明申请
    Chemotactic peptide antagonists for imaging sites of inflammation 审中-公开
    趋化肽拮抗剂用于成像炎症部位

    公开(公告)号：US20050100507A1

    公开(公告)日：2005-05-12

    申请号：US11014403

    申请日：2004-12-16

    申请人： David Roe ,  Christine Ribic ,  Betty Lawrence ,  Catherine Pollock ,  Alfred Pollack

    发明人： David Roe ,  Christine Ribic ,  Betty Lawrence ,  Catherine Pollock ,  Alfred Pollack

    IPC分类号： A61K51/08 ,  C07K7/02 ,  C07K7/06 ,  A61K51/00 ,  G01N33/53 ,  G01N33/543

    CPC分类号： C07K7/06 ,  A61K51/08 ,  A61K51/088 ,  C07K7/02

    摘要： Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucyl-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t-Butylgly-cys-gly)-glu-trp-phe-leu-nle-NHCOcyclopropyl. The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.

    摘要翻译： 描述了包含靶向白细胞上的N-甲酰基 - 甲硫氨酰 - 亮氨酰 - 苯丙氨酸（fMLF）受体以靶向用于诊断成像的炎症部位的分子的放射性药物。 靶向分子连接到使整个分子成为fMLF受体的拮抗剂或弱激动剂的封端基团，因此不引起导致中性粒细胞减少的趋化性反应。 优选的靶向分子是ReO-Gly-lys（Dimethylgly-t-Butylgly-cys-gly）-glu-trp-phe-leu-nle-NHCO环丙基。 本发明还涉及组合化学的用途以获得靶向诊断成像炎症部位的优选分子。

    Chemotactic peptide antagonists for imaging sites of inflammation
    8.
    发明授权
    Chemotactic peptide antagonists for imaging sites of inflammation 失效
    趋化肽拮抗剂用于成像炎症部位

    公开(公告)号：US06872536B1

    公开(公告)日：2005-03-29

    申请号：US09437701

    申请日：1999-11-10

    申请人： David Roe ,  Christine Maria Ribic ,  Betty Chee-Ion Lawrence ,  Catherine Michelle Pollock ,  Alfred Pollack

    发明人： David Roe ,  Christine Maria Ribic ,  Betty Chee-Ion Lawrence ,  Catherine Michelle Pollock ,  Alfred Pollack

    IPC分类号： A61K51/08 ,  C07K7/02 ,  C07K7/06 ,  A61K38/04 ,  G01N33/53

    CPC分类号： C07K7/06 ,  A61K51/08 ,  A61K51/088 ,  C07K7/02

    摘要： Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucy-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are described. The targeting molecules are attached to capping groups that make the entire molecule either antagonists or weak agonists of fMLF receptor and therefore do not elicit a chemotactic response resulting in neutropenia. The preferred targeting molecule is ReO-Gly-lys(Dimethylgly-t-Butylgly-cys-gly)glu-trp-phe-leu-nle-NHCOcyclopropyl (wherein the peptide sequence NLeu-Leu-Phe-Trp-Glu-Lys-Gly is SEQ. ID No. 1.) The invention also relates to the use of combinatorial chemistry to obtain preferred molecules that target sites of inflammation for diagnostic imaging.

    摘要翻译： 描述了包含靶向白细胞上的N-甲酰基 - 甲硫氨酰 - 亮氨酸 - 苯丙氨酸（fMLF）受体的分子，以靶向用于诊断成像的炎症部位的放射性药物。 靶向分子连接到使整个分子成为fMLF受体的拮抗剂或弱激动剂的封端基团，因此不引起导致中性粒细胞减少的趋化性反应。 优选的靶向分子是ReO-Gly-lys（Dimethylgly-t-Butylgly-cys-gly）glu-trp-phe-leu-nle-NHCO环丙基（其中肽序列NLeu-Leu-Phe-Trp-Glu-Lys-Gly 是SEQ ID NO No.1）。本发明还涉及组合化学的用途来获得靶向诊断成像炎症部位的优选分子。

    Drug delivery apparatus
    9.
    发明授权
    Drug delivery apparatus 有权
    药物输送装置

    公开(公告)号：US08820316B2

    公开(公告)日：2014-09-02

    申请号：US10992920

    申请日：2004-11-19

    申请人： David Roe Crockford ,  John Stanley Harold Denyer

    发明人： David Roe Crockford ,  John Stanley Harold Denyer

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M11/06 ,  A61M16/00

    CPC分类号： A61M11/06 ,  A61M11/002 ,  A61M11/005 ,  A61M15/0018 ,  A61M15/008 ,  A61M15/0086 ,  A61M15/0088 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0024 ,  A61M2016/0036 ,  A61M2205/43 ,  A61M2206/14

    摘要： A drug delivery apparatus comprising: a drug delivery device for selectively delivering drug-laden air or air not laden with the drug; a sensor for monitoring the breathing pattern of a patient; a controller arranged to control the drug delivery device to deliver drug-laden air in pulses which begin when the patient is monitored by the sensor to begin inhalation, the pulses having a duration which is adjusted by the controller on the basis of the monitored breathing pattern of the patient; a feedback indicator which indicates to a patient whether the monitored breathing pattern is effective for inhaling drug-laden air or not a dose calculator which calculates the dose delivered to the patient; and an indicator which indicates to the patient when a desired dose has been delivered, whereby the apparatus is configured to deliver the full amount of the desired dose in at least 80% of treatments.

    摘要翻译： 一种药物输送装置，包括：药物输送装置，用于选择性地输送不含药物的载药空气或空气; 用于监测患者的呼吸模式的传感器; 控制器，其布置成控制药物递送装置以脉冲传送载药的空气，当患者被传感器监测以开始吸入时，该脉冲具有由控制器基于所监测的呼吸模式调节的持续时间 的病人 反馈指示器，其向患者指示所监测的呼吸模式是否对吸入载药空气有效，而不是计算递送给患者的剂量的剂量计算器; 以及当所需剂量已经递送时向患者指示的指示器，由此该装置构造成在至少80％的治疗中递送所需剂量的全部量。

    SUSPENSION SYSTEM FOR HEAVY AND VOCATIONAL VEHICLES
    10.
    发明申请
    SUSPENSION SYSTEM FOR HEAVY AND VOCATIONAL VEHICLES 有权
    重型和职业车辆悬挂系统

    公开(公告)号：US20110115184A1

    公开(公告)日：2011-05-19

    申请号：US12778888

    申请日：2010-05-12

    申请人： Marc Johnson ,  Mark Molitor ,  Jeffrey Michael Galla ,  Jason Klein ,  David Roe ,  Daniel R. Dykstra

    发明人： Marc Johnson ,  Mark Molitor ,  Jeffrey Michael Galla ,  Jason Klein ,  David Roe ,  Daniel R. Dykstra

    IPC分类号： B60G9/02

    CPC分类号： B60G11/27 ,  B60G9/003 ,  B60G9/022 ,  B60G11/28 ,  B60G21/0551 ,  B60G2200/314 ,  B60G2200/315 ,  B60G2202/135

    摘要： A vehicle suspension system includes a first trailing arm assembly and a second trailing assembly each including a mounting bracket adapted to be secured to a vehicle frame and a trailing arm member pivotably coupled to the associated mounting bracket and adapted to be operably coupled to an axle member, wherein the trailing arm members each include an aperture extending therein, wherein the aperture has a relatively constant cross-sectional configuration along a depth thereof. The vehicle suspension system further includes a torsional member extending between the first and second trailing arm members and frictionally secured within the apertures thereof, wherein the torsional member has a relatively constant cross-sectional configuration along a length thereof that is received within the apertures of the trailing arms.

    摘要翻译： 车辆悬挂系统包括第一牵引臂组件和第二牵引组件，每个牵引臂组件包括适于固定到车辆框架的安装支架和可枢转地联接到相关联的安装支架的后臂构件，并且适于可操作地联接到轴构件 其中所述尾臂构件各自包括在其中延伸的孔，其中所述孔沿其深度具有相对恒定的横截面构型。 车辆悬架系统还包括在第一和第二牵引臂构件之间延伸并摩擦地固定在其孔内的扭转构件，其中扭转构件具有沿其长度的相对恒定的横截面构造，该横截面构造被容纳在 拖尾臂。