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1.发明授权Biphenyl compound or pharmaceutically acceptable salt thereof, method for preparing novel biphenyl compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient for preventing or treating diabetes complications 有权联苯化合物或其药学上可接受的盐，制备新型联苯化合物或其药学上可接受的盐的方法和含有其作为预防或治疗糖尿病并发症的活性成分的药物组合物公开(公告)号：US08785503B2
公开(公告)日：2014-07-22
申请号：US13816402
申请日：2011-08-11
申请人： Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-Sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
发明人： Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-Sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
IPC分类号： A01N31/14 , A61K31/075
CPC分类号： C07C43/23 , A21D2/24 , A23C2240/15 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K36/73 , C07C41/38 , A23V2200/328 , A23V2250/156 , A23V2250/70
摘要： The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
摘要翻译： 本发明提供了一种新的联苯化合物或其药学上可接受的盐，其制备方法，以及用于预防或治疗含有其作为活性成分的糖尿病并发症的药物组合物。 根据本发明的新型联苯化合物有效地抑制了引起糖尿病并发症的晚期糖基化终产物的产生活性，并且是评价治疗剂对糖尿病并发症的有效性的标准，对视网膜血管显示出优异的治疗效果 ，增加闭合蛋白，并减少血管生成生长因子在实际糖尿病视网膜病变诱导的视网膜。 因此，根据本发明的新型联苯化合物可以有效地用作用于预防或治疗糖尿病性视网膜病变的糖尿病并发症的组合物中的活性成分。
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2.发明申请NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING DIABETES COMPLICATIONS 有权新型联苯化合物或其药学上可接受的盐，制备新型联苯化合物或其药学上可接受的盐的方法，以及含有作为活性成分的药物组合物，用于预防或治疗糖尿病并发症公开(公告)号：US20130210928A1
公开(公告)日：2013-08-15
申请号：US13816402
申请日：2011-08-11
申请人： Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
发明人： Jin Sook Kim , Young Sook Kim , Jung Hyun Kim , Eun Jin Shon , Ki Mo Kim , Chan-sik Kim , Dong Ho Jung , Yun Mi Lee , Kyu Hyung Jo , Ohn Soon Kim , Nam-Hee Yoo
CPC分类号： C07C43/23 , A21D2/24 , A23C2240/15 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K36/73 , C07C41/38 , A23V2200/328 , A23V2250/156 , A23V2250/70
摘要： The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
摘要翻译： 本发明提供了一种新的联苯化合物或其药学上可接受的盐，其制备方法，以及用于预防或治疗含有其作为活性成分的糖尿病并发症的药物组合物。 根据本发明的新型联苯化合物有效地抑制了引起糖尿病并发症的晚期糖基化终产物的产生活性，并且是评价治疗剂对糖尿病并发症的有效性的标准，对视网膜血管显示出优异的治疗效果 ，增加闭合蛋白，并减少血管生成生长因子在实际糖尿病视网膜病变诱导的视网膜。 因此，根据本发明的新型联苯化合物可以有效地用作用于预防或治疗糖尿病性视网膜病变的糖尿病并发症的组合物中的活性成分。
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3.发明申请COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 失效用OSTEOMEL SCHWERINAE治疗和预防糖尿病并发症的组合物公开(公告)号：US20120100233A1
公开(公告)日：2012-04-26
申请号：US13381493
申请日：2009-11-05
申请人： Jin Sook Kim , Dae Sik Jang , Young Sook Kim , Yun Mi Lee , Joo-Hwan Kim , Eunjin Shon , Junghyun Kim , Chan-Sik Kim , Ohn Soon Kim , Dong Ho Jung , Nan Hee Kim , Nam-Hee Yoo , Jun Lee
发明人： Jin Sook Kim , Dae Sik Jang , Young Sook Kim , Yun Mi Lee , Joo-Hwan Kim , Eunjin Shon , Junghyun Kim , Chan-Sik Kim , Ohn Soon Kim , Dong Ho Jung , Nan Hee Kim , Nam-Hee Yoo , Jun Lee
CPC分类号： A61K36/73 , A23L33/105
摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles schwerinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles schwerinae extract and its fraction as an active ingredient.
摘要翻译： 本发明涉及糖尿病并发症的治疗剂，以及使用其治疗糖尿病并发症的方法。 本发明证实，石脑油提取物及其成分抑制AGEs的产生，糖尿病并发症的指标，抑制醛糖还原酶的活化，具有抗白内障活性，具有抗氧化活性。 因此，本发明涉及包含所述骨髓提取物及其部分作为活性成分的糖尿病并发症的预防和治疗剂。
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4.发明授权Pharmaceutical composition for preventing and treating complications of diabetes containing a traditional oriental medicine extract or a fraction thereof as an active ingredient 有权用于预防和治疗含有传统东方医药提取物或其部分的糖尿病并发症的药物组合物作为活性成分公开(公告)号：US09446081B2
公开(公告)日：2016-09-20
申请号：US13983802
申请日：2011-03-07
申请人： Jin Sook Kim, I , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
发明人： Jin Sook Kim, I , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
CPC分类号： A61K36/00 , A23C2240/15 , A23K20/10 , A23K50/10 , A23K50/30 , A23K50/75 , A23L2/52 , A23L13/426 , A23L23/00 , A23L29/03 , A23L33/105 , A61K36/47
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.
摘要翻译： 本发明涉及一种用于预防和治疗糖尿病并发症的药物组合物，其包含同源鬣蜥的提取物。 或其部分作为活性成分。 更具体地说，是茉莉花的提取物。 或者其本发明的级分可以抑制醛糖还原酶的活性和产生晚期糖基化终末产物，糖尿病并发症的指标，并且具有强大的抑制糖尿病并发症的活性，同时具有抗白内障，抗视网膜病变和 抗神经病变作用，并且具有抗氧化的活性，因此它们可以有效地用作预防和治疗糖尿病并发症的药物组合物的活性成分。
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5.发明授权Compositions for treatment and prevention of diabetic complications using Osteomeles schwerinae 失效用于治疗和预防使用骨质疏松症的糖尿病并发症的组合物公开(公告)号：US08784911B2
公开(公告)日：2014-07-22
申请号：US13381493
申请日：2009-11-05
申请人： Jin Sook Kim , Dae Sik Jang , Young Sook Kim , Yun Mi Lee , Joo-Hwan Kim , Eunjin Shon , Junghyun Kim , Chan-Sik Kim , Dong Ho Jung , Nan Hee Kim , Nam-Hee Yoo , Jun Lee
发明人： Jin Sook Kim , Dae Sik Jang , Young Sook Kim , Yun Mi Lee , Joo-Hwan Kim , Eunjin Shon , Junghyun Kim , Chan-Sik Kim , Dong Ho Jung , Nan Hee Kim , Nam-Hee Yoo , Jun Lee
IPC分类号： A61K36/73
CPC分类号： A61K36/73 , A23L33/105
摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles schwerinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles schwerinae extract and its fraction as an active ingredient.
摘要翻译： 本发明涉及糖尿病并发症的治疗剂，以及使用其治疗糖尿病并发症的方法。 本发明证实，石脑油提取物及其成分抑制AGEs的产生，糖尿病并发症的指标，抑制醛糖还原酶的活化，具有抗白内障活性，具有抗氧化活性。 因此，本发明涉及包含所述骨髓提取物及其部分作为活性成分的糖尿病并发症的预防和治疗剂。
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6.发明申请公开(公告)号：US20130316030A1
公开(公告)日：2013-11-28
申请号：US13983802
申请日：2011-03-07
申请人： Jin Sook Kim , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
发明人： Jin Sook Kim , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
IPC分类号： A61K36/00
CPC分类号： A61K36/00 , A23C2240/15 , A23K20/10 , A23K50/10 , A23K50/30 , A23K50/75 , A23L2/52 , A23L13/426 , A23L23/00 , A23L29/03 , A23L33/105 , A61K36/47
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.
摘要翻译： 本发明涉及一种用于预防和治疗糖尿病并发症的药物组合物，其包含同源鬣蜥的提取物。 或其部分作为活性成分。 更具体地说，是茉莉花的提取物。 或者其本发明的级分可以抑制醛糖还原酶的活性和产生晚期糖基化终末产物，糖尿病并发症的指标，并且具有强大的抑制糖尿病并发症的活性，同时具有抗白内障，抗视网膜病变和 抗神经病变作用，并且具有抗氧化的活性，因此它们可以有效地用作预防和治疗糖尿病并发症的药物组合物的活性成分。
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