公开(公告)号：US08785503B2

公开(公告)日：2014-07-22

申请号：US13816402

申请日：2011-08-11

申请人： Jin Sook Kim ,  Young Sook Kim ,  Jung Hyun Kim ,  Eun Jin Shon ,  Ki Mo Kim ,  Chan-Sik Kim ,  Dong Ho Jung ,  Yun Mi Lee ,  Kyu Hyung Jo ,  Ohn Soon Kim ,  Nam-Hee Yoo

发明人： Jin Sook Kim ,  Young Sook Kim ,  Jung Hyun Kim ,  Eun Jin Shon ,  Ki Mo Kim ,  Chan-Sik Kim ,  Dong Ho Jung ,  Yun Mi Lee ,  Kyu Hyung Jo ,  Ohn Soon Kim ,  Nam-Hee Yoo

IPC分类号： A01N31/14 ,  A61K31/075

CPC分类号： C07C43/23 ,  A21D2/24 ,  A23C2240/15 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/73 ,  C07C41/38 ,  A23V2200/328 ,  A23V2250/156 ,  A23V2250/70

摘要： The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.

摘要翻译： 本发明提供了一种新的联苯化合物或其药学上可接受的盐，其制备方法，以及用于预防或治疗含有其作为活性成分的糖尿病并发症的药物组合物。 根据本发明的新型联苯化合物有效地抑制了引起糖尿病并发症的晚期糖基化终产物的产生活性，并且是评价治疗剂对糖尿病并发症的有效性的标准，对视网膜血管显示出优异的治疗效果 ，增加闭合蛋白，并减少血管生成生长因子在实际糖尿病视网膜病变诱导的视网膜。 因此，根据本发明的新型联苯化合物可以有效地用作用于预防或治疗糖尿病性视网膜病变的糖尿病并发症的组合物中的活性成分。

公开(公告)号：US09446081B2

公开(公告)日：2016-09-20

申请号：US13983802

申请日：2011-03-07

申请人： Jin Sook Kim, I ,  Jung Hyun Kim ,  Young Sook Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Eun Jin Shon ,  Nam-Hee Yoo ,  Yun Mi Lee ,  Dong Ho Jung

发明人： Jin Sook Kim, I ,  Jung Hyun Kim ,  Young Sook Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Eun Jin Shon ,  Nam-Hee Yoo ,  Yun Mi Lee ,  Dong Ho Jung

IPC分类号： A61K36/47 ,  A61K36/00 ,  A23L1/30 ,  A23L1/314 ,  A23L1/39 ,  A23L2/52 ,  A23K1/16 ,  A23K1/18

CPC分类号： A61K36/00 ,  A23C2240/15 ,  A23K20/10 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L2/52 ,  A23L13/426 ,  A23L23/00 ,  A23L29/03 ,  A23L33/105 ,  A61K36/47

摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.

摘要翻译： 本发明涉及一种用于预防和治疗糖尿病并发症的药物组合物，其包含同源鬣蜥的提取物。 或其部分作为活性成分。 更具体地说，是茉莉花的提取物。 或者其本发明的级分可以抑制醛糖还原酶的活性和产生晚期糖基化终末产物，糖尿病并发症的指标，并且具有强大的抑制糖尿病并发症的活性，同时具有抗白内障，抗视网膜病变和 抗神经病变作用，并且具有抗氧化的活性，因此它们可以有效地用作预防和治疗糖尿病并发症的药物组合物的活性成分。

公开(公告)号：US20130316030A1

公开(公告)日：2013-11-28

申请号：US13983802

申请日：2011-03-07

申请人： Jin Sook Kim ,  Jung Hyun Kim ,  Young Sook Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Eun Jin Shon ,  Nam-Hee Yoo ,  Yun Mi Lee ,  Dong Ho Jung

发明人： Jin Sook Kim ,  Jung Hyun Kim ,  Young Sook Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Eun Jin Shon ,  Nam-Hee Yoo ,  Yun Mi Lee ,  Dong Ho Jung

IPC分类号： A61K36/00

CPC分类号： A61K36/00 ,  A23C2240/15 ,  A23K20/10 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L2/52 ,  A23L13/426 ,  A23L23/00 ,  A23L29/03 ,  A23L33/105 ,  A61K36/47

摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.

摘要翻译： 本发明涉及一种用于预防和治疗糖尿病并发症的药物组合物，其包含同源鬣蜥的提取物。 或其部分作为活性成分。 更具体地说，是茉莉花的提取物。 或者其本发明的级分可以抑制醛糖还原酶的活性和产生晚期糖基化终末产物，糖尿病并发症的指标，并且具有强大的抑制糖尿病并发症的活性，同时具有抗白内障，抗视网膜病变和 抗神经病变作用，并且具有抗氧化的活性，因此它们可以有效地用作预防和治疗糖尿病并发症的药物组合物的活性成分。

公开(公告)号：US20120100233A1

公开(公告)日：2012-04-26

申请号：US13381493

申请日：2009-11-05

申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Yun Mi Lee ,  Joo-Hwan Kim ,  Eunjin Shon ,  Junghyun Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Dong Ho Jung ,  Nan Hee Kim ,  Nam-Hee Yoo ,  Jun Lee

发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Yun Mi Lee ,  Joo-Hwan Kim ,  Eunjin Shon ,  Junghyun Kim ,  Chan-Sik Kim ,  Ohn Soon Kim ,  Dong Ho Jung ,  Nan Hee Kim ,  Nam-Hee Yoo ,  Jun Lee

IPC分类号： A61K36/73 ,  A61P43/00 ,  A61P35/00 ,  A61P3/10

CPC分类号： A61K36/73 ,  A23L33/105

摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles schwerinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles schwerinae extract and its fraction as an active ingredient.

摘要翻译： 本发明涉及糖尿病并发症的治疗剂，以及使用其治疗糖尿病并发症的方法。 本发明证实，石脑油提取物及其成分抑制AGEs的产生，糖尿病并发症的指标，抑制醛糖还原酶的活化，具有抗白内障活性，具有抗氧化活性。 因此，本发明涉及包含所述骨髓提取物及其部分作为活性成分的糖尿病并发症的预防和治疗剂。

公开(公告)号：US08784911B2

公开(公告)日：2014-07-22

申请号：US13381493

申请日：2009-11-05

申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Yun Mi Lee ,  Joo-Hwan Kim ,  Eunjin Shon ,  Junghyun Kim ,  Chan-Sik Kim ,  Dong Ho Jung ,  Nan Hee Kim ,  Nam-Hee Yoo ,  Jun Lee

发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Yun Mi Lee ,  Joo-Hwan Kim ,  Eunjin Shon ,  Junghyun Kim ,  Chan-Sik Kim ,  Dong Ho Jung ,  Nan Hee Kim ,  Nam-Hee Yoo ,  Jun Lee

IPC分类号： A61K36/73

CPC分类号： A61K36/73 ,  A23L33/105

摘要： The present invention relates to a treatment agent for diabetic complications, and a method for the treatment of diabetic complications using the same. The present invention confirmed that Osteomeles schwerinae extract and its fractions inhibited the generation of AGEs, the index for diabetic complications, inhibited the activation of aldose reductase, had anti-cataract activity, and had anti-oxidative activity. Thus, the present invention relates to a preventive and therapeutic agent for diabetic complications containing the said Osteomeles schwerinae extract and its fraction as an active ingredient.

摘要翻译： 本发明涉及糖尿病并发症的治疗剂，以及使用其治疗糖尿病并发症的方法。 本发明证实，石脑油提取物及其成分抑制AGEs的产生，糖尿病并发症的指标，抑制醛糖还原酶的活化，具有抗白内障活性，具有抗氧化活性。 因此，本发明涉及包含所述骨髓提取物及其部分作为活性成分的糖尿病并发症的预防和治疗剂。

公开(公告)号：US20120183633A1

公开(公告)日：2012-07-19

申请号：US13498247

申请日：2009-12-29

申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

IPC分类号： A61K36/704 ,  A61P3/06 ,  A61P3/00 ,  A61P3/04

CPC分类号： A61K36/704 ,  A23L33/105

摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.

摘要翻译： 本发明涉及枸杞子枸杞子和枸杞子乙酸乙酯级分的肥胖治疗或肥胖预防效果，更具体地说，涉及用于治疗肥胖症的药物组合物和功能性食品，药物组合物和功能性食品 包括枸杞子丁醇级分（POCU-1b）和乙酸乙酯级分作为活性成分，其中枸杞子丁醇级分和乙酸乙酯级分有效地抑制了胰脂肪酶的活性，胰脂肪酶是涉及活体脂肪吸收的重要酶， 在使用脂质乳剂的短期脂肪吸收抑制动物实验中对脂肪吸收具有优异的抑制作用。

公开(公告)号：US09504725B2

公开(公告)日：2016-11-29

申请号：US13498247

申请日：2009-12-29

申请人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

发明人： Jin Sook Kim ,  Dae Sik Jang ,  Young Sook Kim ,  Junghyun Kim ,  Chan-Sik Kim

IPC分类号： A61K36/704

CPC分类号： A61K36/704 ,  A23L33/105

摘要： The present invention relates to the obesity-curative or obesity-preventive effect of a Polygonum cuspidatum butanol fraction and a Polygonum cuspidatum ethylacetate fraction, and more particularly, to a pharmaceutical composition and a functional food for treating obesity, the pharmaceutical composition and the functional food comprising a Polygonum cuspidatum butanol fraction (POCU-1b) and an ethylacetate fraction as active ingredients, wherein the Polygonum cuspidatum butanol fraction and the ethylacetate fraction inhibit effectively the activity of pancreatic lipase, an important enzyme involving in fat absorption in a living body, and have excellent inhibitory effect on fat absorption in the short term fat absorption-inhibitory animal experiments using lipid emulsions.

摘要翻译： 本发明涉及枸杞子枸杞子和枸杞子乙酸乙酯级分的肥胖治疗或肥胖预防效果，更具体地说，涉及用于治疗肥胖症的药物组合物和功能性食品，药物组合物和功能性食品 包括枸杞子丁醇级分（POCU-1b）和乙酸乙酯级分作为活性成分，其中枸杞子丁醇级分和乙酸乙酯级分有效地抑制了胰脂肪酶的活性，胰脂肪酶是涉及活体脂肪吸收的重要酶， 在使用脂质乳剂的短期脂肪吸收抑制动物实验中对脂肪吸收具有优异的抑制作用。

公开(公告)号：US09248409B2

公开(公告)日：2016-02-02

申请号：US13575362

申请日：2011-01-27

申请人： Soo-Hong Noh ,  Oh-Sung Kwon ,  Young-Keun Choi ,  Chan-Sik Kim ,  Seung-Il Lee ,  Woo-Seung Choi

发明人： Soo-Hong Noh ,  Oh-Sung Kwon ,  Young-Keun Choi ,  Chan-Sik Kim ,  Seung-Il Lee ,  Woo-Seung Choi

IPC分类号： B01D69/08 ,  B01D63/02 ,  B01D63/04 ,  B01D65/10 ,  B01D65/02 ,  B01D61/18 ,  C02F1/44

CPC分类号： B01D63/04 ,  B01D61/18 ,  B01D63/024 ,  B01D65/02 ,  B01D65/10 ,  B01D2313/08 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/16 ,  B01D2313/18 ,  B01D2313/20 ,  B01D2313/26 ,  B01D2321/185 ,  C02F1/444

摘要： Provided is a hollow-fiber membrane module comprising a submodule inside which raw water is circulated and water treatment is carried out, and a piping unit which is connected to the submodule and through which the raw water and air and treated water flow, such that flow rates can be increased and energy consumption can be minimized through the circulation of a fluid.

摘要翻译： 提供一种中空纤维膜组件，其包括在其内循环原水并进行水处理的子模块，以及连接到子模块并且原水和空气以及经处理的水流过的管道单元，使得流 可以通过流体的循环来提高速率并且能够最小化能量消耗。

公开(公告)号：US20120292248A1

公开(公告)日：2012-11-22

申请号：US13575362

申请日：2011-01-27

申请人： Soo-Hong Noh ,  Oh-Sung Kwon ,  Young-Keun Choi ,  Chan-Sik Kim ,  Seung-Il Lee ,  Woo-Seung Choi

发明人： Soo-Hong Noh ,  Oh-Sung Kwon ,  Young-Keun Choi ,  Chan-Sik Kim ,  Seung-Il Lee ,  Woo-Seung Choi

IPC分类号： B01D69/04

CPC分类号： B01D63/04 ,  B01D61/18 ,  B01D63/024 ,  B01D65/02 ,  B01D65/10 ,  B01D2313/08 ,  B01D2313/10 ,  B01D2313/12 ,  B01D2313/16 ,  B01D2313/18 ,  B01D2313/20 ,  B01D2313/26 ,  B01D2321/185 ,  C02F1/444

摘要： Provided is a hollow-fibre membrane module comprising a submodule inside which raw water is circulated and water treatment is carried out, and a piping unit which is connected to the submodule and through which the raw water and air and treated water flow, such that flow rates can be increased and energy consumption can be minimised through the circulation of a fluid, and the advantages of internal-pressure type and external-pressure type systems can be incorporated in a composite fashion.

摘要翻译： 提供一种中空纤维膜组件，其包括在其内循环原水并进行水处理的子模块，以及连接到子模块并且原水和空气以及经处理的水流过的管道单元，使得流 可以通过流体的循环来提高速率并且可以最小化能量消耗，并且可以以复合方式并入内压型和外压型系统的优点。