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    Compounds exhibiting efflux inhibitor activity and composition and uses thereof
    1.
    发明申请
    Compounds exhibiting efflux inhibitor activity and composition and uses thereof 审中-公开
    表现出外排抑制剂活性的组合物及其用途的化合物

    公开(公告)号：US20070254859A1

    公开(公告)日：2007-11-01

    申请号：US11730362

    申请日：2007-03-30

    申请人： Michael Wempe ,  Kevin Edgar ,  John Hyatt ,  George Zima

    发明人： Michael Wempe ,  Kevin Edgar ,  John Hyatt ,  George Zima

    IPC分类号： A61K31/58 ,  C07J17/00

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/352 ,  A61K31/355 ,  A61K31/56 ,  C07J17/00 ,  A61K2300/00

    摘要： At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R2, R3, R4 and R5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR4—, —S—, —SO— and —SO2—, wherein R4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR4R5—, —NH—, —NR4—, —NO—, —O—, —NOR4—, —S—, —SO—, —SO2—, wherein R4 and R5 are defined as above; R1 is chosen from a tocopherol, a steroid and a flavonoid; and R6 is chosen from any R1, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.

    摘要翻译： 至少一种选自式I化合物的化合物：其药学上可接受的盐或酯，其溶剂化物，其螯合物，其非共价复合物，其前药，以及任何前述物质的混合物，其中：n为 1至900的数字，其中各个单元可以相同或不同; W选自烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; R 2，R 3，R 4和R 5中的每一个独立地选自-H，烷基， 取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基; Z'选自-O - ， - N-，-NO - ， - NR 4 - ， - S - ， - SO-和-SO 2 - ，其中 R 4如上定义; X，X'，Y和Z中的每一个独立地选自-CR 4 R 5 - ， - NH - ， - NR 4 - ，-NO - ， - O - ， - NOR 4 - ， - S - ， - SO - ， - SO 2 - ，其中R 4 和R 5定义如上; R 1选自生育酚，类固醇和类黄酮; R 6选自任何R 1，C 1，C 1，C 3，C 6烷基，取代的烷基，环烷基，取代的环烷基，芳基，取代的芳基，芳烷基和取代的芳烷基。

    Sucrose acetate isobutyrate formulation
    2.
    发明申请
    Sucrose acetate isobutyrate formulation 审中-公开
    醋酸蔗糖异丁酸酯制剂

    公开(公告)号：US20050106304A1

    公开(公告)日：2005-05-19

    申请号：US10713937

    申请日：2003-11-14

    申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

    发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

    IPC分类号： A23L1/22 ,  A23L2/385 ,  A23L2/39 ,  A23L2/40 ,  A23L2/52 ,  A23L2/56 ,  A23L2/62 ,  C12C1/00

    CPC分类号： A23L2/56 ,  A23L2/52 ,  A23L2/62 ,  A23L27/80 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/5022 ,  A23V2250/1944

    摘要： The present invention provides a solid sucrose acetate isobutyrate (SAIB) formulation, comprising sucrose acetate isobutyrate in an amount from about 1 weight percent to about 80 weight percent based on the total weight percent of the total solid formulation; and a solid substrate that is soluble in water or oil, wherein the substrate is present in an amount from about 99 weight percent to about 30 weight percent based on the weight of the formulation, wherein the formulation is pourable in less than about 20 seconds according to ASTM method D1895-96. The SAIB formulation is useful in beverage applications.

    摘要翻译： 本发明提供固体蔗糖乙酸异丁酸酯（SAIB）制剂，其包含占总固体制剂总重量百分比约1重量％至约80重量％的蔗糖乙酸异丁酸酯; 和可溶于水或油的固体基质，其中所述底物的存在量为制剂重量的约99重量％至约30重量％，其中所述制剂在少于约20秒内可倾倒，根据 根据ASTM方法D1895-96。 SAIB配方可用于饮料应用。

    Sucrose acetate isobutyrate formulation
    3.
    发明申请
    Sucrose acetate isobutyrate formulation 审中-公开
    醋酸蔗糖异丁酸酯制剂

    公开(公告)号：US20070104850A1

    公开(公告)日：2007-05-10

    申请号：US11643047

    申请日：2006-12-20

    申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

    发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

    IPC分类号： A23L2/00

    CPC分类号： A23L2/56 ,  A23L2/52 ,  A23L2/62 ,  A23L27/80 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/5022 ,  A23V2250/1944

    摘要： The present invention provides a process for producing a solid sucrose acetate isobutyrate (SAIB) formulation, by combining sucrose acetate isobutyrate in an amount from about 1 weight percent to about 80 weight percent based on the total weight percent of the total solid formulation; and a solid substrate that is soluble in water or oil, wherein the substrate is present in an amount from about 99 weight percent to about 30 weight percent based on the weight of the formulation, wherein the formulation produced is pourable in less than about 20 seconds according to ASTM method D1895-96. The solid SAIB formulation is useful in beverage applications.

    摘要翻译： 本发明提供了一种制备固体蔗糖醋酸异丁酸酯（SAIB）制剂的方法，其中以相对于总固体制剂的总重量百分数计约1％至约80％重量的蔗糖乙酸异丁酯; 和可溶于水或油的固体基质，其中基于制剂重量，基质的存在量为约99重量％至约30重量％，其中所制备的制剂在少于约20秒内是可倾倒的 根据ASTM方法D1895-96。 固体SAIB配方可用于饮料应用。