公开(公告)号：US20050106304A1

公开(公告)日：2005-05-19

申请号：US10713937

申请日：2003-11-14

申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

IPC分类号： A23L1/22 ,  A23L2/385 ,  A23L2/39 ,  A23L2/40 ,  A23L2/52 ,  A23L2/56 ,  A23L2/62 ,  C12C1/00

CPC分类号： A23L2/56 ,  A23L2/52 ,  A23L2/62 ,  A23L27/80 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/5022 ,  A23V2250/1944

摘要： The present invention provides a solid sucrose acetate isobutyrate (SAIB) formulation, comprising sucrose acetate isobutyrate in an amount from about 1 weight percent to about 80 weight percent based on the total weight percent of the total solid formulation; and a solid substrate that is soluble in water or oil, wherein the substrate is present in an amount from about 99 weight percent to about 30 weight percent based on the weight of the formulation, wherein the formulation is pourable in less than about 20 seconds according to ASTM method D1895-96. The SAIB formulation is useful in beverage applications.

摘要翻译： 本发明提供固体蔗糖乙酸异丁酸酯（SAIB）制剂，其包含占总固体制剂总重量百分比约1重量％至约80重量％的蔗糖乙酸异丁酸酯; 和可溶于水或油的固体基质，其中所述底物的存在量为制剂重量的约99重量％至约30重量％，其中所述制剂在少于约20秒内可倾倒，根据 根据ASTM方法D1895-96。 SAIB配方可用于饮料应用。

公开(公告)号：US20070104850A1

公开(公告)日：2007-05-10

申请号：US11643047

申请日：2006-12-20

申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

IPC分类号： A23L2/00

CPC分类号： A23L2/56 ,  A23L2/52 ,  A23L2/62 ,  A23L27/80 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/5022 ,  A23V2250/1944

摘要： The present invention provides a process for producing a solid sucrose acetate isobutyrate (SAIB) formulation, by combining sucrose acetate isobutyrate in an amount from about 1 weight percent to about 80 weight percent based on the total weight percent of the total solid formulation; and a solid substrate that is soluble in water or oil, wherein the substrate is present in an amount from about 99 weight percent to about 30 weight percent based on the weight of the formulation, wherein the formulation produced is pourable in less than about 20 seconds according to ASTM method D1895-96. The solid SAIB formulation is useful in beverage applications.

摘要翻译： 本发明提供了一种制备固体蔗糖醋酸异丁酸酯（SAIB）制剂的方法，其中以相对于总固体制剂的总重量百分数计约1％至约80％重量的蔗糖乙酸异丁酯; 和可溶于水或油的固体基质，其中基于制剂重量，基质的存在量为约99重量％至约30重量％，其中所制备的制剂在少于约20秒内是可倾倒的 根据ASTM方法D1895-96。 固体SAIB配方可用于饮料应用。

公开(公告)号：US20050171052A1

公开(公告)日：2005-08-04

申请号：US10989064

申请日：2004-11-15

申请人： Phillip Cook ,  George Zima ,  Danessa Sexton

发明人： Phillip Cook ,  George Zima ,  Danessa Sexton

IPC分类号： A23L2/52 ,  A23L2/62 ,  A23L29/00 ,  A61K8/60 ,  A61K31/7024 ,  A61Q19/00

CPC分类号： A23L2/52 ,  A23L2/62 ,  A61K8/60 ,  A61Q19/00

摘要： The present invention provides a solid sucrose acetate isobutyrate formulation having improved handling characteristics.

摘要翻译： 本发明提供具有改进的处理特性的固体蔗糖醋酸酯异丁酸酯制剂。

公开(公告)号：US20050051419A1

公开(公告)日：2005-03-10

申请号：US10659620

申请日：2003-09-10

申请人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

发明人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

IPC分类号： A21D2/10 ,  A21D2/14 ,  A23D7/005 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23L1/24 ,  A23L1/30 ,  A23L2/52 ,  A61K8/92 ,  A61Q19/00 ,  B01D1/06 ,  B01D1/22 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  C07C7/04 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00

CPC分类号： C07C7/04 ,  A21D2/10 ,  A21D2/14 ,  A23D7/0053 ,  A23D7/0056 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23L2/52 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A61K8/922 ,  A61Q19/00 ,  A61Q19/001 ,  B01D1/065 ,  B01D1/22 ,  B01D1/222 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  B01D3/143 ,  B01D3/146 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00 ,  Y02W30/74

摘要： Disclosed is a process for the recovery of a phytolipid composition from a vegetable oil by-product. The phytolipid composition produced comprises squalene, phytosterols, mixed tocopherols and tocotrieneols, and vegetable wax and is useful as an emollient. The phytochemical composition may be applied directly to the skin to provide emolliency. Alternatively, the phytolipid composition may be formulated in various aqueous or anhydrous cosmetic compositions such as creams, lotions, gels, ointments, lip balms, sticks, or pencils for treatment of the skin and lips. The phytolipid composition also may be incorporated into foods, beverages, and nutraceuticals to provide health benefits.

公开(公告)号：US20050053712A1

公开(公告)日：2005-03-10

申请号：US10844074

申请日：2004-05-12

申请人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

发明人： George Zima ,  Terry Oldfield ,  Suzanne Dobbs ,  Phillip Cook ,  Charles Kelly ,  Mary Crow ,  Craig Hoyme

IPC分类号： A21D2/10 ,  A21D2/14 ,  A23D7/005 ,  A23D7/01 ,  A23D7/015 ,  A23D9/013 ,  A23L1/24 ,  A23L1/30 ,  A23L2/52 ,  A61K8/92 ,  A61Q19/00 ,  B01D1/06 ,  B01D1/22 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  C07C7/04 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00 ,  C07D311/04

CPC分类号： C07C7/04 ,  A21D2/10 ,  A21D2/14 ,  A23D7/0053 ,  A23D7/0056 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23L2/52 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A61K8/922 ,  A61Q19/00 ,  A61Q19/001 ,  B01D1/065 ,  B01D1/22 ,  B01D1/222 ,  B01D1/26 ,  B01D3/10 ,  B01D3/12 ,  B01D3/14 ,  B01D3/143 ,  B01D3/146 ,  C07J9/00 ,  C11B11/00 ,  C11B13/00 ,  Y02W30/74

摘要： Disclosed is a process for the recovery of a phytolipid composition from a vegetable oil by-product. The phytolipid composition produced comprises squalene, phytosterols, mixed tocopherols and tocotrieneols, and vegetable wax and is useful as an emollient. The phytochemical composition may be applied directly to the skin to provide emolliency. Alternatively, the phytolipid composition may be formulated in various aqueous or anhydrous cosmetic compositions such as creams, lotions, gels, ointments, lip balms, sticks, or pencils for treatment of the skin and lips. The phytolipid composition also may be incorporated into foods, beverages, and nutraceuticals to provide health benefits.

摘要翻译： 公开了从植物油副产物中回收植脂油组合物的方法。 所生产的植物油脂组合物包括角鲨烯，植物甾醇，混合生育酚和邻苯三酚，以及植物蜡，并且可用作润肤剂。 植物化学成分可以直接施用于皮肤以提供润肤性。 或者，植物油脂组合物可以配制成各种水性或无水化妆品组合物，例如乳膏，洗剂，凝胶，软膏，唇膏，棒或铅笔，用于治疗皮肤和嘴唇。 植物油脂组合物还可以并入食品，饮料和营养品中以提供健康益处。

公开(公告)号：US20060205686A1

公开(公告)日：2006-09-14

申请号：US11236224

申请日：2005-09-27

申请人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Steven Carroll ,  Malcolm MacCoss ,  David Olsen

发明人： Balkrishen Bhat ,  Anne Eldrup ,  Thazha Prakash ,  Phillip Cook ,  Steven Carroll ,  Malcolm MacCoss ,  David Olsen

IPC分类号： A61K31/7056 ,  A61K31/7076

CPC分类号： C07H19/16 ,  A61K9/4858 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  C07D473/00 ,  C07D487/04 ,  C07H19/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/12 ,  C07H19/14 ,  C07H19/20 ,  Y02P20/582 ,  A61K2300/00

摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

公开(公告)号：USD491874S1

公开(公告)日：2004-06-22

申请号：US29196342

申请日：2003-12-29

申请人： Phillip Cook

设计人： Phillip Cook

公开(公告)号：US20080032945A1

公开(公告)日：2008-02-07

申请号：US11764086

申请日：2007-06-15

申请人： Phillip Cook ,  Andrew Kawasaki

发明人： Phillip Cook ,  Andrew Kawasaki

IPC分类号： A61K31/7125

CPC分类号： C07H21/04 ,  A61K31/7125 ,  A61K38/00 ,  A61K48/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H23/00 ,  C07J43/003 ,  C12N9/0069 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/333 ,  C12N2310/336 ,  C12N2310/3521 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12Q1/68 ,  C12Y113/11012

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

摘要翻译： 提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。 提供了治疗各种病毒和其他致病因素引起的疾病。

公开(公告)号：US20070135363A1

公开(公告)日：2007-06-14

申请号：US11674954

申请日：2007-02-14

申请人： Phillip Cook ,  Gregory Ewing ,  Deborah Ewing ,  Yi Jin ,  John Lambert ,  Marija Prhavc ,  Vasanthankumar Rajappan ,  Vivek Rajwanshi ,  Kandasamy Sakthivel

发明人： Phillip Cook ,  Gregory Ewing ,  Deborah Ewing ,  Yi Jin ,  John Lambert ,  Marija Prhavc ,  Vasanthankumar Rajappan ,  Vivek Rajwanshi ,  Kandasamy Sakthivel

IPC分类号： A61K31/7052 ,  C07H19/04

CPC分类号： C07H19/04 ,  C07H19/23

摘要： Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.

摘要翻译： 含有三环碱基的核苷和核苷酸分别用于治疗感染性疾病和增殖性疾病，例如病毒感染或癌症。

公开(公告)号：US20060052589A1

公开(公告)日：2006-03-09

申请号：US11249578

申请日：2005-10-13

申请人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

发明人： Michael Cyr ,  Max Weaver ,  Gerry Rhodes ,  Jason Pearson ,  Phillip Cook

IPC分类号： C09B29/32 ,  C07D221/18

CPC分类号： C09B69/109 ,  C08F246/00 ,  C08F290/06 ,  C08F290/14 ,  C09B69/101 ,  C09B69/105 ,  C09B69/106

摘要： Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.