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    Capture and release assay system and method
    1.
    发明申请
    Capture and release assay system and method 审中-公开
    捕获和释放测定系统和方法

    公开(公告)号：US20060211055A1

    公开(公告)日：2006-09-21

    申请号：US11440615

    申请日：2006-05-24

    申请人： Dean Hafeman ,  H. Wada ,  Anton Simeonov

    发明人： Dean Hafeman ,  H. Wada ,  Anton Simeonov

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/54306

    摘要： A method for detecting one or more components of interest in a fluid-borne sample in a microchannel of a microfluidic device includes flowing the fluid-borne sample, in which the one or more components of interest are bound to a first labeled component binding moiety to form a first labeled complex, through a binding channel region of the microchannel. The binding channel region includes a second component-binding moiety reversibly bound to a wall surface of the binding channel region. At least a portion of the one or more components of interest is bound to the second component-binding moiety to form a second labeled complex. The second labeled complex is released from the binding channel region and flowed through a detection channel region of the microchannel, where the second labeled complex is detected.

    摘要翻译： 用于检测微流体装置的微通道中的流体样品中的一种或多种感兴趣组分的方法包括使流体传播的样品流动，其中所述一种或多种感兴趣的组分与第一标记的组分结合部分结合， 通过微通道的结合通道区形成第一标记的复合物。 结合通道区域包括可逆结合到结合通道区域的壁表面的第二组分结合部分。 感兴趣的一种或多种组分的至少一部分与第二组分结合部分结合以形成第二标记复合物。 第二标记的复合物从结合通道区域释放并流过微通道的检测通道区域，其中检测到第二标记复合物。

    Reduction of migration shift assay interference
    2.
    发明申请
    Reduction of migration shift assay interference 有权
    减少迁移移位测定干扰

    公开(公告)号：US20050170362A1

    公开(公告)日：2005-08-04

    申请号：US10821657

    申请日：2004-04-08

    申请人： H. Wada ,  Irina Kazakova ,  Miki Yutaka ,  Toshinari Ohashi ,  Futoshi Kanke

    发明人： H. Wada ,  Irina Kazakova ,  Miki Yutaka ,  Toshinari Ohashi ,  Futoshi Kanke

    IPC分类号： B01L3/00 ,  C12Q1/68 ,  G01N30/02 ,  G01N30/34 ,  G01N30/86 ,  G01N33/53 ,  G01N33/538 ,  G01N33/561

    CPC分类号： G01N30/8644 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N30/02 ,  G01N30/34 ,  G01N33/5306 ,  G01N33/538 ,  G01N33/561 ,  B01D15/34

    摘要： This invention provides methods and compositions, e.g., to reduce interference from non-specific binding sample constituents in a migration shift assay. Interference due to non-specific binding of sample constituents to an affinity substance (e.g., an affinity molecule or a conjugate of an affinity molecule and a charged carrier molecule) is prevented by, e.g., binding the constituents to charged polymers such as heparin sulfate. The present invention also provides methods to concentrate an analyte of interest with high concentration and to detect the analyte with high sensitivity, and further to optimize the reaction conditions for easily concentrating the analyte. Such objects of the present invention are attained, for example, by concentrating a complex of the analyte and a conjugate which is formed by contacting the analyte in a sample with an affinity molecule bound to a charged carrier molecule such as DNA.

    摘要翻译： 本发明提供了方法和组合物，例如在迁移移位测定中减少非特异性结合样品组分的干扰。 通过例如将成分与带电​​聚合物如硫酸肝素结合来防止由于样品成分对亲和性物质（例如亲和分子或亲和分子和带电载体分子的结合物）的非特异性结合的干扰。 本发明还提供了高浓度浓缩目的分析物并以高灵敏度检测分析物的方法，并进一步优化用于容易地浓缩分析物的反应条件。 本发明的这些目的可以通过例如浓缩分析物和通过将样品中的分析物与结合到带电荷的载体分子如DNA的亲和分子接触而形成的缀合物进行浓缩来实现。

    Multi-function travel case
    8.
    发明授权
    Multi-function travel case 有权
    多功能旅行箱

    公开(公告)号：US07503440B2

    公开(公告)日：2009-03-17

    申请号：US10939346

    申请日：2004-09-14

    申请人： Todd M. Gormick ,  Stanley H. Wada ,  Hrag Nassanian ,  Grace Chang ,  Hing Yeung ,  Alex Rochat

    发明人： Todd M. Gormick ,  Stanley H. Wada ,  Hrag Nassanian ,  Grace Chang ,  Hing Yeung ,  Alex Rochat

    IPC分类号： A45C13/18 ,  A45C13/42 ,  A45C13/02

    CPC分类号： A45C15/06 ,  A45C3/02 ,  A45C5/06 ,  A45C13/02 ,  A45C13/36 ,  A45C13/42

    摘要： A multi-function travel case includes a plurality of features for facilitating ease of travel, including a retractable document sleeve for storing important travel-related documents in a manner that allows for quick, secure and easy access, viewing and storage of same during travel. The travel case further includes a retractable bottle holder extendable from a side pocket thereof, a side storage compartment adapted for storing eyeglasses in a manner that prevents scratching of same, a front interior storage compartment that houses a retractable light source, a key holder, and integrated pockets adapted for the storage of optical media without scratching the same, a central interior storage compartment having an adjustable top restraint and first and second user-positionable, impact resistant, adjustable cushions for securing portable computer devices of different sizes, a rear interior storage compartment having a removable file folder housed therein, ergonomically-designed rubber handles, and anti-tip feet.

    摘要翻译： 多功能旅行箱包括用于便于行驶的多个特征，包括用于以允许在旅行期间快速，安全和容易地访问，观察和存储重要旅行相关文件的可伸缩文件套筒。 旅行箱还包括可从其侧袋延伸的可伸缩瓶保持架，适于以防止刮擦的方式存放眼镜的侧储存室，容纳可伸缩光源的前内部储存室，钥匙架和 集成的口袋，适用于光学介质的存储而不会刮擦光学介质;具有可调节的顶部约束的中央内部存储隔间以及用于固定不同尺寸的便携式计算机设备的第一和第二用户可定位，抗冲击，可调节的衬垫，后部内部存储 隔间具有容纳在其中的可移动的文件夹，符合人体工程学设计的橡胶手柄和反尖端脚。

    Multi-function travel case
    9.
    发明授权
    Multi-function travel case 有权
    多功能旅行箱

    公开(公告)号：US07467695B2

    公开(公告)日：2008-12-23

    申请号：US10939333

    申请日：2004-09-14

    申请人： Todd M. Gormick ,  Stanley H. Wada ,  Hrag Nassanian ,  Grace Chang ,  Hing Yeung ,  Alex Rochat

    发明人： Todd M. Gormick ,  Stanley H. Wada ,  Hrag Nassanian ,  Grace Chang ,  Hing Yeung ,  Alex Rochat

    IPC分类号： A45C13/02 ,  A45C13/42

    CPC分类号： A45C3/02 ,  A45C5/06 ,  A45C13/02 ,  A45C13/023 ,  A45C13/103 ,  A45C13/1046 ,  A45C13/18 ,  A45C13/26 ,  A45C13/262 ,  A45C13/36 ,  A45C13/42 ,  A45C15/06 ,  A45C2013/025 ,  A45C2013/306 ,  A45F5/004 ,  A45F2200/0583

    摘要： A multi-function travel case includes a plurality of features for facilitating ease of travel, including a retractable document sleeve for storing important travel-related documents in a manner that allows for quick, secure and easy access, viewing and storage of same during travel. The travel case further includes a retractable bottle holder extendable from a side pocket thereof, a side storage compartment adapted for storing eyeglasses in a manner that prevents scratching of same, a front interior storage compartment that houses a retractable light source, a key holder, and integrated pockets adapted for the storage of optical media without scratching the same, a central interior storage compartment having an adjustable top restraint and first and second user-positionable, impact resistant, adjustable cushions for securing portable computer devices of different sizes, a rear interior storage compartment having a removable file folder housed therein, ergonomically-designed rubber handles, and anti-tip feet.

    摘要翻译： 多功能旅行箱包括用于便于行驶的多个特征，包括用于以允许在旅行期间快速，安全和容易地访问，观察和存储重要旅行相关文件的可伸缩文件套筒。 旅行箱还包括可从其侧袋延伸的可伸缩瓶保持架，适于以防止刮擦的方式存放眼镜的侧储存室，容纳可伸缩光源的前内部储存室，钥匙架和 集成的口袋，适用于光学介质的存储而不会刮擦光学介质;具有可调节的顶部约束的中央内部存储隔间以及用于固定不同尺寸的便携式计算机设备的第一和第二用户可定位，抗冲击，可调节的衬垫，后部内部存储 隔间具有容纳在其中的可移动的文件夹，符合人体工程学设计的橡胶手柄和反尖端脚。

    Deflectable catheter with ergonomic handle
    10.
    发明授权
    Deflectable catheter with ergonomic handle 失效
    具有人体工程学手柄的可折叠导管

    公开(公告)号：US06203507B1

    公开(公告)日：2001-03-20

    申请号：US09262136

    申请日：1999-03-03

    申请人： John F. Wadsworth ,  J. Kevin Clay ,  Stanley H. Wada ,  Edward V. Cruz

    发明人： John F. Wadsworth ,  J. Kevin Clay ,  Stanley H. Wada ,  Edward V. Cruz

    IPC分类号： A61B500

    CPC分类号： A61M25/0147 ,  A61B5/042 ,  A61B18/1492 ,  A61M25/0136 ,  A61M2025/015

    摘要： A deflectable catheter comprises a catheter body, a tip section and a control handle. The Control handle, which is preferably curved, comprises a housing having a generally hollow interior, a piston receiving assembly at least partially within the interior of the housing, and a piston. The piston receiving assembly is afforded rotational movement but not longitudinal movement relative to the housing and comprises a generally tubular member defining a piston chamber. The piston is fixedly attached to the proximal end of the catheter body and extends into the piston chamber of the piston receiving assembly, wherein the piston is afforded longitudinal movement but not rotational movement relative to the piston receiving assembly. Rotation of the piston relative to the housing correspondingly rotates the piston receiving assembly, catheter body and tip section. A puller wire extends from the control handle, through a lumen in the catheter body and into a lumen in the tip section. The proximal end of the puller wire is anchored in the control handle, whereby distal movement of the piston relative to the piston receiving assembly results in distal movement of the catheter body relative to the puller wire. The puller wire is anchored in the tip section so that to distal movement of the catheter body relative to the puller wire deflects the tip section.

    摘要翻译： 可挠性导管包括导管主体，尖端部分和控制手柄。 优选弯曲的控制手柄包括具有大致中空的内部的壳体，至少部分地在壳体内部的活塞接收组件和活塞。 活塞接收组件相对于壳体提供旋转运动而不是纵向运动，并且包括限定活塞室的大致管状构件。 活塞固定地附接到导管主体的近端并延伸到活塞接收组件的活塞室中，其中活塞被提供纵向运动，但不是相对于活塞接收组件的旋转运动。 活塞相对于壳体的旋转相应地使活塞接收组件，导管主体和尖端部分旋转。 拉线从控制手柄延伸通过导管主体中的内腔并进入尖端部分的内腔。 牵引线的近端锚定在控制手柄中，由此活塞相对于活塞接收组件的远端运动导致导管主体相对于拉线的远端移动。 牵引线锚定在尖端部分中，使得导管主体相对于牵引线的远端运动使尖端部分偏转。