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    Process for purifying and stabilizing catechol-containing proteins and materials obtained thereby
    1.
    发明授权
    Process for purifying and stabilizing catechol-containing proteins and materials obtained thereby 失效
    用于纯化和稳定含儿茶酚的蛋白质和由此得到的材料的方法

    公开(公告)号：US4496397A

    公开(公告)日：1985-01-29

    申请号：US587181

    申请日：1984-03-07

    申请人： J. Herbert Waite

    发明人： J. Herbert Waite

    IPC分类号： A23J1/04 ,  C09J189/00 ,  C07G7/00 ,  C08L89/00 ,  C09J3/20

    CPC分类号： C09J189/00 ,  A23J1/04 ,  Y10S530/857

    摘要： A process is provided for purifying and stabilizing marine mussel polyphenolic proteins rich in 3,4-dihydroxyphenylalanine (dopa) and hydroxyproline (hyp) while obtaining high yields thereof. The process includes the steps of providing an acid soluble extract of the dopa-containing proteins, removing the low molecular weight material from the extract and reacting the remaining proteinaceous material with a water soluble borate at a pH of 7.0-9.0 to provide a soluble borate complex of the dopa-containing protein while precipitating impurities. The complex is separated from the precipitate and may be concentrated for storage or treated with an acetic acid solution and either concentrated or lyophilized and stored under an inert atmosphere. The purified proteins exhibit a dopa:protein index of purity ratio of at least about 0.10.

    摘要翻译： 提供了一种纯化和稳定富含3,4-二羟基苯丙氨酸（多巴）和羟脯氨酸（hyp）的海洋贻贝多酚蛋白的方法，同时获得高产率。 该方法包括以下步骤：提供含多巴蛋白质的酸溶性提取物，从提取物中除去低分子量物质，并将剩余的蛋白质物质与pH9.0-9.0的水溶性硼酸盐反应，得到可溶性硼酸盐 含多巴的蛋白质的复合物同时沉淀杂质。 将复合物与沉淀物分离，并且可以浓缩用于储存或用乙酸溶液处理，并将其浓缩或冻干并在惰性气氛下储存。 纯化的蛋白质显示出多巴：蛋白质的纯度比指数至少约为0.10。

    Polypeptide monomers, linearly extended and/or crosslinked forms thereof, and applications thereof
    4.
    发明授权
    Polypeptide monomers, linearly extended and/or crosslinked forms thereof, and applications thereof 失效
    多肽单体，其线性延伸和/或交联形式及其应用

    公开(公告)号：US5574134A

    公开(公告)日：1996-11-12

    申请号：US839745

    申请日：1992-02-19

    申请人： J. Herbert Waite

    发明人： J. Herbert Waite

    IPC分类号： C07K14/435 ,  A61K38/04

    CPC分类号： C07K14/43504

    摘要： A water-resistant polyphenolic protein adhesive has been obtained from the Atlantic ribbed mussel, Geukensia (Modiolus) demissa. This protein provides a natural model for synthetic or bioengineered adhesives and is characterized by a Gly-Tyr-Lys or, more frequently, Gly-Dop-Lys "tail" fragment of a repeating octapeptide or nonapeptide unit. A complete octapeptide or nonapeptide unit (including both the 5- or 6-amino acid residue "head" as well as the 3-residue "tail") can be represented as follows:[Gln]Glu].sub.x -Thr/Ala-Gly-Dop/Tyr-Y.sup.1 -Y.sup.2 -Gly-Tyr/Dop-Lyswhere x is zero or one,Y.sup.1 is Val, Leu, Asp or Ser, andY.sup.2 is Ala, Pro, Hyp, or Leu.The tripeptide "tail" and/or the 5- or 6-residue "head" of the polypeptide is useful as a single unit (curable with difunctional crosslinkers or the like) or as a repeating unit.

    摘要翻译： 已经从大西洋罗纹贻贝（Geusensia（Modiolus）demissa）获得了耐水多酚蛋白粘合剂。 该蛋白提供了合成或生物工程化粘合剂的天然模型，其特征在于重复八肽或单肽单元的Gly-Tyr-Lys或更频繁的Gly-Dop-Lys“尾”片段。 完整的八肽或非肽单元（包括5-或6-氨基酸残基“头”以及3-残基“尾”）可以表示如下：[Gln] Glu] x-Thr / Ala-Gly -Dop / Tyr-Y1-Y2-Gly-Tyr / Dop-Lys，其中x为0或1，Y1为Val，Leu，Asp或Ser，Y2为Ala，Pro，Hyp或Leu。 多肽“尾”和/或该多肽的5-或6-残基“头”可用作单一单元（可用双功能交联剂等固化）或作为重复单元。

    Integrated task management systems and methods for executing rule-based operations
    6.
    发明申请
    Integrated task management systems and methods for executing rule-based operations 有权
    用于执行基于规则的操作的集成任务管理系统和方法

    公开(公告)号：US20050248806A1

    公开(公告)日：2005-11-10

    申请号：US11097578

    申请日：2005-04-01

    申请人： Kenneth Klein ,  Herbert Waite ,  George Starr ,  Nathan Warmbrod

    发明人： Kenneth Klein ,  Herbert Waite ,  George Starr ,  Nathan Warmbrod

    IPC分类号： G06F3/12 ,  G06F15/00 ,  G06F17/00 ,  G06K1/00 ,  G06N5/00 ,  G06N5/02 ,  G06Q10/00 ,  G06F17/60

    CPC分类号： G06F3/126 ,  G06N5/02 ,  G06Q10/10 ,  G06Q50/184

    摘要： A system for integrating multiple software modules configured to produce output according to established business rules is provided. The system in one embodiment coordinates the printing of a variety of labels and reports according to a set of complex business rules. Complex output tasks may be distributed to remote computers in a network for optimum efficiency. The system may be configured to comply with one or more standard database connectivity standards in order to provide a generic interface with foreign systems. The method in one embodiment includes acquiring an input, sending a query to a database, retrieving business rules and associated tasks, and building scripts or commands for each task. This Abstract is provided to comply with the rules, which require an abstract to quickly inform a searcher or other reader about the subject matter of the application. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

    摘要翻译： 提供了一种用于集成多个软件模块的系统，用于根据既定的业务规则配置产生输出。 一个实施例中的系统根据一组复杂的业务规则协调各种标签和报告的打印。 复杂的输出任务可以被分发到网络中的远程计算机以获得最佳效率。 该系统可以被配置为符合一个或多个标准数据库连接标准，以提供与外部系统的通用接口。 在一个实施例中的方法包括获取输入，向数据库发送查询，检索业务规则和相关联的任务，以及为每个任务构建脚本或命令。 提供本摘要以符合规则，这些规则需要一个摘要来快速通知搜索者或其他读者关于申请的主题。 提交本摘要的理解是，它不会用于解释或限制权利要求的范围或含义。

    Decapeptides produced from bioadhesive polyphenolic proteins
    7.
    发明授权
    Decapeptides produced from bioadhesive polyphenolic proteins 失效
    从生物粘附多酚蛋白产生的十肽

    公开(公告)号：US4808702A

    公开(公告)日：1989-02-28

    申请号：US55450

    申请日：1987-06-01

    申请人： J. Herbert Waite

    发明人： J. Herbert Waite

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C07C103/52 ,  C12P21/06

    CPC分类号： C07K14/435 ,  A61K38/00 ,  Y10S930/29

    摘要： Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the group comprising hydrogen and methyl, from bioadhesive polyphenolic proteins which comprise: ##STR2## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently sselected from the group comprising hydrogen and methyl.Such decapeptides may be used to construct large polyphenolic molecules comprising from about 1 to about 1000 decapeptide repeating units and wherein the linking group is selected from the group comprising amino acid, oligopeptide and bifunctional spacer.

    摘要翻译： 描述了用于制备和分离下式的新型十肽的方法：其中每个X独立地选自羟基和氢，其中每个R独立地选自包括以下的基团： 氢和甲基，来自生物粘附多酚蛋白，其包含：其中n为约60至约100的整数，其中每个X独立地选自羟基和氢，以及 其中每个R独立地选自氢和甲基的基团。 这种十肽可用于构建包含约1至约1000个十肽重复单元的大多酚分子，并且其中该连接基团选自氨基酸，寡肽和双功能间隔基。

    Decapeptides produced from bioadhesive polyphenolic proteins
    8.
    发明授权
    Decapeptides produced from bioadhesive polyphenolic proteins 失效
    从生物粘附多酚蛋白产生的十肽

    公开(公告)号：US4687740A

    公开(公告)日：1987-08-18

    申请号：US820143

    申请日：1986-01-21

    申请人： J. Herbert Waite

    发明人： J. Herbert Waite

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12P21/06

    CPC分类号： C07K14/435 ,  A61K38/00

    摘要： Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the group containing hydrogen and methyl, from bioadhesive polyphenolic proteins which comprise: ##STR2## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently selected from the group comprising hydrogen and methyl.Such decapeptides may be used to construct large polyphenolic molecules comprising from about 1 to about 1000 decapeptide repeating units and wherein the linking group is selected from the group comprising amino acid, oligopeptide and bifunctional spacer.

    摘要翻译： 描述了用于制备和分离下式的新型十肽的方法：其中每个X独立地选自羟基和氢，其中每个R独立地选自含有（C 1 -C 6） 氢和甲基，来自生物粘附多酚蛋白，其包含：其中n为约60至约100的整数，其中每个X独立地选自羟基和氢，以及 其中每个R独立地选自氢和甲基。 这种十肽可用于构建包含约1至约1000个十肽重复单元的大多酚分子，并且其中该连接基团选自氨基酸，寡肽和双功能间隔基。

    Decapeptides produced from bioadhesive polyphenolic proteins
    9.
    发明授权
    Decapeptides produced from bioadhesive polyphenolic proteins 失效
    从生物粘附多酚蛋白产生的十肽

    公开(公告)号：US4585585A

    公开(公告)日：1986-04-29

    申请号：US587132

    申请日：1984-03-07

    申请人： J. Herbert Waite

    发明人： J. Herbert Waite

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C12P21/06

    CPC分类号： C07K14/435 ,  A61K38/00

    摘要： Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the group comprising hydrogen and methyl, from bioadhesive polyphenolic proteins which comprise: ##STR2## wherein n is a whole number from about 60 to about 100, wherein each X is independently selected from the group comprising hydroxyl and hydrogen, and wherein each R is independently selected from the group comprising hydrogen and methyl.Such decapeptides may be used to construct large polyphenolic molecules comprising from about 1 to about 1000 decapeptide repeating units and wherein the linking group is selected from the group comprising amino acid, oligopeptide and bifunctional spacer.

    摘要翻译： 描述了用于制备和分离下式的新型十肽的方法：其中每个X独立地选自羟基和氢，其中每个R独立地选自包括以下的基团： 氢和甲基，来自生物粘附多酚蛋白，其包含：其中n为约60至约100的整数，其中每个X独立地选自羟基和氢，以及 其中每个R独立地选自氢和甲基。 这种十肽可用于构建包含约1至约1000个十肽重复单元的大多酚分子，并且其中该连接基团选自氨基酸，寡肽和双功能间隔基。