公开(公告)号：US20240108727A1

公开(公告)日：2024-04-04

申请号：US18255289

申请日：2021-12-02

申请人： InovoBiologic, Inc.

发明人： Roland Jacques Gahler ,  Simon Wood ,  Chuck Chang ,  Yun Chai Kuo

IPC分类号： A61K47/20 ,  A61K31/352 ,  A61K47/10 ,  A61K47/14

CPC分类号： A61K47/20 ,  A61K31/352 ,  A61K47/10 ,  A61K47/14

摘要： The present disclosure describes compositions including a eutectic matrix that includes methylsulfonylmethane and a sugar alcohol and particles of a nutraceutical in the eutectic matrix. In some embodiments, the sugar alcohol:methylsulfonylmethane ratio may be from 95:5 to 20:80. Also provided herein are methods for making the compositions and methods for increasing solubility and bioavailability of a nutraceutical.

公开(公告)号：US20190105286A1

公开(公告)日：2019-04-11

申请号：US16143194

申请日：2018-09-26

申请人： InovoBiologic Inc.

发明人： Chuck Chang ,  Sangho Lee ,  Youngse Jang ,  Yoon Seok Roh

IPC分类号： A61K31/12 ,  A61K9/48

摘要： Provided herein are solid form water soluble curcuminoid compositions, including a curcuminoid; and a solubilization matrix, wherein the solubilization matrix includes methylsulfonylmethane (MSM). Also provided herein are methods for producing various curcuminoid compositions.

公开(公告)号：US09669051B2

公开(公告)日：2017-06-06

申请号：US14394337

申请日：2013-04-22

申请人： Inovobiologic Inc.

发明人： Roland Jacques Gahler ,  Michael Robert Lyon ,  Simon Wood

IPC分类号： A61K47/36 ,  A61K31/734 ,  A61K31/155 ,  A61K31/4985 ,  A61K31/723 ,  A61K31/736 ,  A61K9/16 ,  A61K9/48 ,  A23L33/00

CPC分类号： A61K31/734 ,  A23L33/40 ,  A23V2200/02 ,  A23V2200/3262 ,  A23V2200/328 ,  A23V2250/5026 ,  A23V2250/505 ,  A23V2250/5086 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/155 ,  A61K31/4985 ,  A61K31/723 ,  A61K31/736 ,  A61K2300/00

摘要： A pharmaceutical composition composed of a dietary fiber composition composed of from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate in combination with at least one of metformin or sitagliptin or a combination thereof is described. The pharmaceutical composition is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.

公开(公告)号：US11446259B2

公开(公告)日：2022-09-20

申请号：US16143194

申请日：2018-09-26

申请人： InovoBiologic Inc.

发明人： Chuck Chang ,  Sangho Lee ,  Youngse Jang ,  Yoon Seok Roh

IPC分类号： A61K31/12 ,  A61K9/14 ,  A61K9/48

摘要： Provided herein are water soluble solid form compositions including a curcuminoid; and a solubilizer selected from one or more of methylsulfonylmethane (MSM) and steviol glycoside; glycerol polyethylene glycol hydroxystearate (GPGH) and steviol glycoside; fatty acid glycerol polyglycoester (GPE); steviol glycoside and an aromatic amino acid; and steviol glycoside. Also provided herein are methods of making the water soluble solid form compositions.

公开(公告)号：US20150086621A1

公开(公告)日：2015-03-26

申请号：US14394337

申请日：2013-04-22

申请人： Inovobiologic Inc.

发明人： Roland Jacques Gahler ,  Michael Robert Lyon ,  Simon Wood

IPC分类号： A61K31/734 ,  A61K31/736 ,  A61K9/48 ,  A61K31/723 ,  A61K31/155 ,  A61K31/4985

CPC分类号： A61K31/734 ,  A23L33/40 ,  A23V2200/02 ,  A23V2200/3262 ,  A23V2200/328 ,  A23V2250/5026 ,  A23V2250/505 ,  A23V2250/5086 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/155 ,  A61K31/4985 ,  A61K31/723 ,  A61K31/736 ,  A61K2300/00

摘要： Dietary fibre compositions composed of 48-90% w/w glucomannan, 5-20% w/w xanthan gum and 5-30% w/w alginate in combination with metformin, sitagliptin or a mixture thereof for the treatment of metabolic disease are disclosed.

摘要翻译： 公开了由48-90％w / w葡甘露聚糖，5-20％w / w黄原胶和5-30％w / w藻酸盐与二甲双胍，西他列汀或其混合物组合用于治疗代谢性疾病的膳食纤维组合物 。

公开(公告)号：US11980214B2

公开(公告)日：2024-05-14

申请号：US17776539

申请日：2020-11-12

申请人： InovoBiologic Inc.

发明人： Roland Jacques Gahler ,  Simon Wood

IPC分类号： A61K36/00 ,  A23L29/244 ,  A23L29/256 ,  A23L29/269 ,  A23L33/22 ,  A61P3/04

CPC分类号： A23L33/22 ,  A23L29/244 ,  A23L29/256 ,  A23L29/27 ,  A61P3/04

摘要： A dietary composition comprising (i) from about 40% to about 80% (w/w) of a fiber composition comprising glucomannan, xanthan gum, and alginate; and (ii) from about 10% to about 60% (w/w) psyllium is provided, along with a method and a food product for promoting satiety, promoting weight loss, lowering blood cholesterol levels or lowering blood glucose levels in a mammal.

公开(公告)号：US20220346428A1

公开(公告)日：2022-11-03

申请号：US17776539

申请日：2020-11-12

申请人： InovoBiologic Inc.

发明人： Roland Jacques Gahler ,  Simon Wood

IPC分类号： A23L33/22 ,  A23L29/244 ,  A23L29/256 ,  A23L29/269 ,  A61P3/04

摘要： A dietary composition comprising (i) from about 40% to about 80% (w/w) of a fiber composition comprising glucomannan, xanthan gum, and alginate; and (ii) from about 10% to about 60% (w/w) psyllium is provided, along with a method and a food product for promoting satiety, promoting weight loss, lowering blood cholesterol levels or lowering blood glucose levels in a mammal.

公开(公告)号：US20190105285A1

公开(公告)日：2019-04-11

申请号：US16143188

申请日：2018-09-26

申请人： InovoBiologic Inc.

发明人： Chuck Chang ,  Sangho Lee ,  Youngse Jang ,  Yoon Seok Roh

IPC分类号： A61K31/12 ,  A61K9/48

摘要： Provided herein are solid form water soluble curcuminoid compositions, including a curcuminoid; and a solubilization matrix, wherein the solubilization matrix is selected from one or more of the following: (i) chlorophyllin (CHL); (ii) green tea extract; (iii) epigallocatechin gallate (EGCG); (iv) Rutin; and (v) an aromatic amino acid. Alternatively, the solubilization matrix may include methylsulfonylmethane (MSM). Also provided herein are methods for producing curcuminoid compositions.

公开(公告)号：US10010102B2

公开(公告)日：2018-07-03

申请号：US14068139

申请日：2013-10-31

申请人： InovoBiologic Inc.

发明人： Roland Gahler ,  Michael Lyon

IPC分类号： A23L29/244 ,  A61K31/723 ,  A23L29/256 ,  A23L29/269 ,  A23L33/115 ,  A23L33/12 ,  A23L33/21 ,  A23L33/22

CPC分类号： A23L29/244 ,  A23L29/256 ,  A23L29/27 ,  A23L33/115 ,  A23L33/12 ,  A23L33/21 ,  A23L33/22 ,  A61K31/723

摘要： One aspect of the invention provides dietary fiber compositions comprising effective amounts of glucomannan, xanthan gum, and alginate to produce a desired viscosity. The invention also provides food products comprising an effective amount of a dietary fiber composition. In other aspects, the invention provides methods for preparing a dietary fiber composition or a food product comprising a dietary fiber composition and methods for promoting satiety, promoting weight loss, lowering blood glucose levels, or lowering blood cholesterol levels in a mammal.

公开(公告)号：US20140120239A1

公开(公告)日：2014-05-01

申请号：US14068139

申请日：2013-10-31

申请人： InovoBiologic Inc.

发明人： Roland Gahler ,  Michael Lyon ,  Nicole Lee

IPC分类号： A23L1/308

CPC分类号： A23L29/244 ,  A23L29/256 ,  A23L29/27 ,  A23L33/115 ,  A23L33/12 ,  A23L33/21 ,  A23L33/22 ,  A61K31/723

摘要： One aspect of the invention provides dietary fiber compositions comprising effective amounts of glucomannan, xanthan gum, and alginate to produce a desired viscosity. The invention also provides food products comprising an effective amount of a dietary fiber composition. In other aspects, the invention provides methods for preparing a dietary fiber composition or a food product comprising a dietary fiber composition and methods for promoting satiety, promoting weight loss, lowering blood glucose levels, or lowering blood cholesterol levels in a mammal.

摘要翻译： 本发明的一个方面提供包含有效量的葡甘露聚糖，黄原胶和藻酸盐以产生所需粘度的膳食纤维组合物。 本发明还提供了包含有效量的膳食纤维组合物的食品。 在其他方面，本发明提供了制备膳食纤维组合物或食品的方法，其包含膳食纤维组合物和用于促进哺乳动物的饱腹感，促进体重减轻，降低血糖水平或降低血液胆固醇水平的方法。