公开(公告)号：US4278665A

公开(公告)日：1981-07-14

申请号：US844412

申请日：1977-10-21

申请人： Peter Traxler ,  Johannes Gruner ,  Jakob Nuesch

发明人： Peter Traxler ,  Johannes Gruner ,  Jakob Nuesch

IPC分类号： A01N63/02 ,  A61K31/70 ,  A61K31/7024 ,  A61P31/04 ,  C07H7/04 ,  C07H13/04 ,  C07H19/01 ,  C12P1/02 ,  C12P19/12 ,  C12P19/44 ,  C12P19/60 ,  C12R1/645 ,  A61K31/71 ,  C07H17/04

CPC分类号： C07H19/01 ,  C12P19/12 ,  C12R1/645

摘要： The new antibiotic "Papulacandin" is obtained by the cultivation of the microorganism Papularia sphaerosperma (Pers.) Hohnel, especially of the strain NRRL 8086, under aerobic conditions in an aqueous nutrient medium. There can also be used mutants of said microorganisms. Papulacandin consists of various components A, B, C, D and E, the more important of which are A and B, whose structures have been elucidated to a great extent: they contain only carbon, hydrogen and oxygen. Papulacandin and its components have a strong anti-fungal action, for instance against Candida albicans, and can be used for combating infections caused by pathogenic fungi.

摘要翻译： 新的抗生素“Papulacandin”是通过在有氧条件下在含水营养培养基中培养微生物Papularia spherersperma（Pers。）Höhnel，特别是NRRL 8086菌株获得的。 还可以使用所述微生物的突变体。 帕拉坎卡因由各种组分A，B，C，D和E组成，其中更重要的是A和B，其结构在很大程度上被阐明：它们仅含有碳，氢和氧。 Papulacandin及其组分具有强烈的抗真菌作用，例如对抗白色念珠菌，并且可用于对抗致病真菌引起的感染。

公开(公告)号：US5093247A

公开(公告)日：1992-03-03

申请号：US477087

申请日：1990-02-08

申请人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

发明人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/18 ,  C07H17/02 ,  C12N1/20 ,  C12P17/12 ,  C12P19/60 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07D221/18 ,  C07H17/02 ,  C12P17/12 ,  C12P19/60 ,  Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

公开(公告)号：US4939158A

公开(公告)日：1990-07-03

申请号：US230941

申请日：1988-08-11

申请人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

发明人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/18 ,  C07H17/02 ,  C12N1/20 ,  C12P17/12 ,  C12P19/60 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07D221/18 ,  C07H17/02 ,  C12P17/12 ,  C12P19/60 ,  Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

摘要翻译： 本发明涉及1,8-二羟基-3-甲基苯并[b]菲啶-7,12-二酮及其衍生物，其中R 1是氢或式II的基团（II） ）和化合物的盐，其中R 1是式II的基团。 这些化合物可以通过新的微生物过程获得并用于治疗肿瘤。