公开(公告)号：US5093247A

公开(公告)日：1992-03-03

申请号：US477087

申请日：1990-02-08

申请人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

发明人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/18 ,  C07H17/02 ,  C12N1/20 ,  C12P17/12 ,  C12P19/60 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07D221/18 ,  C07H17/02 ,  C12P17/12 ,  C12P19/60 ,  Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

公开(公告)号：US4939158A

公开(公告)日：1990-07-03

申请号：US230941

申请日：1988-08-11

申请人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

发明人： Gabriele Fendrich ,  Willy Zimmermann ,  Johannes Gruner ,  John A. L. Auden

IPC分类号： A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/18 ,  C07H17/02 ,  C12N1/20 ,  C12P17/12 ,  C12P19/60 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07D221/18 ,  C07H17/02 ,  C12P17/12 ,  C12P19/60 ,  Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

摘要翻译： 本发明涉及1,8-二羟基-3-甲基苯并[b]菲啶-7,12-二酮及其衍生物，其中R 1是氢或式II的基团（II） ）和化合物的盐，其中R 1是式II的基团。 这些化合物可以通过新的微生物过程获得并用于治疗肿瘤。

公开(公告)号：US4151783A

公开(公告)日：1979-05-01

申请号：US824334

申请日：1977-08-12

申请人： Willy Zimmermann

发明人： Willy Zimmermann

IPC分类号： B23C3/00 ,  B21G1/04 ,  B21G1/06 ,  B24B9/00 ,  B24B17/02 ,  B24B19/00 ,  B24B19/16 ,  D04B35/02 ,  B23C1/18 ,  B24B5/16 ,  B24B7/04 ,  B24B9/04

CPC分类号： B24B9/00 ,  B21G1/04 ,  B24B17/02 ,  Y10T409/301848 ,  Y10T409/305656 ,  Y10T409/307056

摘要： A flat, elongate workpiece such as a knitting-machine needle, stamped from sheet metal with a transverse lug whose narrow faces require precise machining, is clamped in a workpiece holder with its lug centered on an axis about which the workpiece holder and an associated tool mounting are relatively rotatable. The tool mounting includes two symmetrically positioned supports, carrying respective power-driven shaping tools such as grinding wheels or millers, which are limitedly movable in a plane including the axis and are interconnected by a tension spring drawing them toward each other. An interposed cam disk, engaged by rollers mounted on these supports, determines the extent to which the two shaping tools can approach the axis in machining respective lug faces during a relative rotation of up to 180.degree..

摘要翻译： 一个扁平细长的工件，例如针织机针，冲压有金属板，带有横向凸耳，其窄面需要精密机加工，该工件夹紧在工件保持器中，其凸耳的中心位于工件夹持器和相关工具 安装是相对可旋转的。 工具安装包括两个对称定位的支撑件，其承载相应的动力成型工具，例如砂轮或铣刀，它们在包括轴线的平面中是有限的可移动的，并且通过拉伸弹簧将它们彼此拉直而相互连接。 通过安装在这些支撑件上的滚轮啮合的插入的凸轮盘确定了在相对旋转高达180度时两个成形工具可以在加工相应凸耳面时接近轴的程度。