专利检索 ap:("Gabriele Fendrich" OR "Willy Zimmermann" OR "Johannes Gruner" OR "John A. L. Auden") AND inv:"Gabriele Fendrich" 第 1 页

1.

发明授权
Phenanthridine derivatives, process for the preparation thereof, and compositions containing them 失效
标题翻译：苯并噻吩衍生物，其制备方法及其组合物

公开(公告)号：US5093247A

公开(公告)日：1992-03-03

申请号：US477087

申请日：1990-02-08

申请人： Gabriele Fendrich , Willy Zimmermann , Johannes Gruner , John A. L. Auden

发明人： Gabriele Fendrich , Willy Zimmermann , Johannes Gruner , John A. L. Auden

IPC分类号： A61K31/47 , A61K31/473 , A61P35/00 , C07D221/18 , C07H17/02 , C12N1/20 , C12P17/12 , C12P19/60 , C12R1/465

CPC分类号： C12R1/465 , C07D221/18 , C07H17/02 , C12P17/12 , C12P19/60 , Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

2.

发明授权
Phenanthridine derivatives and compositions containing them 失效
标题翻译：苯胺衍生物和含有它们的组合物

公开(公告)号：US4939158A

公开(公告)日：1990-07-03

申请号：US230941

申请日：1988-08-11

申请人： Gabriele Fendrich , Willy Zimmermann , Johannes Gruner , John A. L. Auden

发明人： Gabriele Fendrich , Willy Zimmermann , Johannes Gruner , John A. L. Auden

IPC分类号： A61K31/47 , A61K31/473 , A61P35/00 , C07D221/18 , C07H17/02 , C12N1/20 , C12P17/12 , C12P19/60 , C12R1/465

CPC分类号： C12R1/465 , C07D221/18 , C07H17/02 , C12P17/12 , C12P19/60 , Y10S435/886

摘要： The invention relates to 1,8-dihydroxy-3-methylbenz[b]phenanthridine-7,12-dione and its derivatives of formula I ##STR1## wherein R.sup.1 is hydrogen or the radical of formula II ##STR2## and salts of the compound, wherein R.sup.1 is the radical of formula II. These compounds can be obtained by means of a novel microbiological process and used for the therapeutic treatment of tumors.

摘要翻译： 本发明涉及1,8-二羟基-3-甲基苯并[b]菲啶-7,12-二酮及其衍生物，其中R 1是氢或式II的基团（II））和化合物的盐，其中R 1是式II的基团。这些化合物可以通过新的微生物过程获得并用于治疗肿瘤。

3.

发明申请
Three-dimensional structure of c-Abl 审中-公开
标题翻译： c-Abl的三维结构

公开(公告)号：US20060030017A1

公开(公告)日：2006-02-09

申请号：US11086482

申请日：2005-03-22

申请人： Gabriele Fendrich , Sandra Jacob , Anthony Klon , Paul Manley

发明人： Gabriele Fendrich , Sandra Jacob , Anthony Klon , Paul Manley

IPC分类号： C12N9/12 , G01N33/48 , G06F19/00

CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/573 , G01N33/5748 , G01N33/6872 , G01N2500/00

摘要： The present invention concerns c-Abl, in particular, the three-dimensional structure of c-Abl containing an active DFG conformation. The atomic coordinates of c-Abl possessing this active DFG motif complexed with a specific ligand are also provided.

摘要翻译： 本发明涉及c-Ab1，特别涉及含有活性DFG构象的c-Abl的三维结构。还提供了具有与特定配体复合的该活性DFG基序的c-Abl的原子坐标。