公开(公告)号：US20250134989A1

公开(公告)日：2025-05-01

申请号：US18931284

申请日：2024-10-30

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  Korea National Institute of Health

Inventor： Won Jong KIM ,  Hong Lyun KIM ,  So Hee PARK ,  Soo-Min KIM ,  Jung-Ah LEE ,  Eunkyung SHIN ,  You-Jin KIM ,  Hye Sook JEONG ,  Dokeun KIM

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61K45/06 ,  A61P31/14 ,  C12N7/00

Abstract: The present invention relates to a novel vaccine composition for coronavirus infection-19 comprising a polymer-based mRNA carrier. Specifically, the present invention provides a vaccine composition comprising an mRNA carrier using a novel polymer capable of delivering a negatively charged genetic material such as mRNA, and the vaccine composition has excellent effects of enhanced in vivo immune activity such as high antibody formation ability and increased interferon-gamma production.

公开(公告)号：US20250027057A1

公开(公告)日：2025-01-23

申请号：US18712093

申请日：2023-04-18

Applicant: KOREA NATIONAL INSTITUTE OF HEALTH

Inventor： Sang Mu SHIM ,  Jung Min LEE ,  Joo Yeon LEE ,  Jungsang RYOU

IPC: C12N7/00 ,  A61K39/12 ,  A61P31/14

Abstract: Provided are high titer Japanese encephalitis virus genotype 5 and uses thereof, specifically a high titer virus produced using subculture and mouse cerebral inoculation method and a vaccine composition comprising the same.

公开(公告)号：US20240316180A1

公开(公告)日：2024-09-26

申请号：US18516257

申请日：2023-11-21

Applicant: Korea National Institute of Health

Inventor： Tae-young LEE ,  Seo Yeon KIM ,  Hyeran WON ,  You-Jin KIM ,  Dokeun KIM

IPC: A61K39/165 ,  A61P31/14 ,  A61P37/04 ,  C12N7/00 ,  G01N33/569

CPC classification number: A61K39/165 ,  A61P31/14 ,  A61P37/04 ,  C12N7/00 ,  G01N33/56983 ,  A61K2039/5254 ,  C12N2760/18721 ,  C12N2760/18722 ,  C12N2760/18734 ,  G01N2333/12

Abstract: The present invention relates to an attenuated mumps virus and a live vaccine comprising the same. The attenuated mumps virus vaccine of the present invention can be effectively used for additional vaccination to control the occurrence of breakthrough infection and the epidemic of mumps due to differences in genotypes of existing vaccine strains and epidemic strains and decreased immunity.

公开(公告)号：US20240417733A1

公开(公告)日：2024-12-19

申请号：US18744136

申请日：2024-06-14

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  Korea University Research and Business Foundation ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Korea National Institute of Health

Inventor： Daehyun BAEK ,  Hee Ryung CHANG ,  Jeong-Sun YANG ,  Hansaem LEE ,  Man-Seong PARK ,  Heedo PARK ,  Yoon Ki KIM ,  Jeeyoon CHANG ,  Joori PARK ,  Joo-Yeon LEE ,  Kyung-Chang KIM

IPC: C12N15/113 ,  A61P31/14

Abstract: The present disclosure relates to a TIS-L targeting antisense oligonucleotide that inhibits the viral replication of SARS-COV-2 and antiviral use thereof. Since the TIS-L targeting antisense oligonucleotide according to the present disclosure has a simple structure, it is easy to mass produce, and as it exhibits antiviral efficacy of 90% or more even at low doses against the original strain and various modified strains of the virus, it can be advantageously utilized in the development of COVID-19 treatment.

公开(公告)号：US20230203101A1

公开(公告)日：2023-06-29

申请号：US17920526

申请日：2021-04-22

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  KOREA NATIONAL INSTITUTE OF HEALTH ,  BIOAPPLICATIONS INC

Inventor： In Hwan HWANG ,  Shijian SONG ,  Rezaul Islam Khan MD ,  Haiping DIAO ,  Eun Ju SOHN ,  Bo Hwa CHOI ,  Jang Hoon CHOI ,  Eun Young JANG ,  Young Jae LEE

IPC: C07K14/005 ,  C12N15/82

CPC classification number: C07K14/005 ,  C12N15/8258 ,  C12N2770/20022 ,  C12N2770/20071 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2770/20051 ,  C12N2511/00

Abstract: The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants.

公开(公告)号：US20250144037A1

公开(公告)日：2025-05-08

申请号：US18941843

申请日：2024-11-08

Applicant: Hongik University Industry-Academia Cooperation Foundation ,  LUCA AICELL, INC. ,  KOREA NATIONAL INSTITUTE OF HEALTH

Inventor： Minsub CHUNG ,  Kyongman AN ,  Taehoon KIM ,  Minjeong KIM ,  Hyunjin KIM ,  Taekyoung LEE ,  Dokeun KIM ,  Hye Sook JEONG ,  Hyeon Guk KIM ,  Jin-Seung YUN

IPC: A61K9/51 ,  A61K39/00 ,  A61K47/10

Abstract: Provided are a mRNA vaccine composition with improved storage stability and a method of improving storage stability of the vaccine composition.