BUILDING RESILIENCE TO COVID-19 AND ITS VARIANTS

    公开(公告)号:US20210337854A1

    公开(公告)日:2021-11-04

    申请号:US17236990

    申请日:2021-04-21

    Applicant: Kaplesh Kumar

    Inventor: Kaplesh Kumar

    Abstract: Method of building resistance to Covid-19 disease development. The strong link between the distribution of Covid-19 disease (CV) severity across the United States population and that of systemic inflammation, as indicated in the individual's C-reactive protein (CRP) level, explains the widely varied symptomatic responses of individuals afflicted with the virus. The data are consistent with the fewer infections and deaths reported for the Asian countries. The disease pathologies of CV and non-specific interstitial pneumonia (NSIP) patients bear close similarities. Modeling the disease as a chemically reactive process indicates that the virus catalyzes the inflammation driven reaction, causing lung infiltration and injury, up to and including patient death. Prevention methods involving exercise and diet successfully applied for lung stabilization in NSIP also apply to CV mitigation, the goal of which is to achieve pre-disease CRP levels of

    Dynamically balanced microelectromechanical devices
    2.
    发明授权
    Dynamically balanced microelectromechanical devices 有权
    动平衡微机电装置

    公开(公告)号:US06571630B1

    公开(公告)日:2003-06-03

    申请号:US09937268

    申请日:2002-07-09

    Abstract: Dynamic balancing reduces quadrature bias in microfabricated vibrating instruments such as tuning fork gyros so that a purity of motion is achieved in the absence of any angular rate input. Balancing is achieved by ablating (74) or depositing (72) onto support structure (62) for a tuning fork gyroscope rather than the proof mass (60) itself by melting and moving material on a tuning fork beam (62). Such adjusting is advantageously done during actual operation of the gyro by laser beam application through an encapsulating transparent cover which can be either part of the chip die or an external package.

    Abstract translation: 动态平衡可减少微型振动仪器(如音叉陀螺仪)中的正交偏差,从而在没有任何角速率输入的情况下实现运动的纯度。 平衡是通过在音叉(62)上熔化和移动材料来消融(74)或沉积(72)到用于音叉陀螺仪而不是证明物质(60)本身的支撑结构(62)上。 这种调整有利地在陀螺仪的实际操作期间通过激光束施加穿过可以是芯片管芯或外部封装的一部分的封装透明盖来完成。

    INFLAMMATORY DISEASE MODEL AND METHOD OF TREATMENT
    4.
    发明申请
    INFLAMMATORY DISEASE MODEL AND METHOD OF TREATMENT 审中-公开
    炎症疾病模型和治疗方法

    公开(公告)号:US20150313916A1

    公开(公告)日:2015-11-05

    申请号:US14455605

    申请日:2014-08-08

    Applicant: Kaplesh Kumar

    Inventor: Kaplesh Kumar

    CPC classification number: A61K31/573 A61K31/366 A61K31/616

    Abstract: Model and method of treating inflammatory diseases. Traditional treatments for such diseases include administering to the patient toxic anti-inflammatory drugs. Following stabilization of the symptoms, the drug doses are tapered down to minimize side effects, as a result of which inflammation remains high and the disease is rarely cured. A chemistry-based disease model concludes that irrespective of the role that inflammation plays in the disease, inflammation reduction will impede disease initiation and progression. Managing and controlling inflammatory diseases requires reducing inflammation to acceptable normal values. Non-toxic ways such as non-steroidal anti-inflammatory drugs, anti-inflammatory diets, and regular exercise allow such reduction in inflammation to normal values, thereby slowing down or arresting disease progression and allowing the discontinuation or reduction of toxic anti-inflammatory therapy while maintaining low inflammation using non-toxic therapy.

    Abstract translation: 治疗炎性疾病的模型和方法。 用于这种疾病的传统疗法包括向患者施用有毒的抗炎药物。 在症状稳定之后,药物剂量逐渐减小,以尽量减少副作用,其结果是炎症仍然很高并且疾病很少被治愈。 基于化学的疾病模型得出结论,不管炎症在疾病中的作用如何,减少炎症将阻碍疾病的发生和发展。 治疗和控制炎性疾病需要将炎症减少到可接受的正常值。 无毒方法如非甾体抗炎药,抗炎饮食和定期运动可使炎症减少到正常值,从而减缓或阻止疾病进展,并允许中止或减少有毒的抗炎治疗 同时使用无毒疗法维持低炎症。

    Radial orientation rare earth-cobalt magnet rings
    5.
    发明授权
    Radial orientation rare earth-cobalt magnet rings 失效
    径向取向稀土钴磁体环

    公开(公告)号:US4533407A

    公开(公告)日:1985-08-06

    申请号:US248798

    申请日:1981-03-30

    CPC classification number: H01F41/026 Y10T29/49076

    Abstract: Apparatus and method for forming radial orientation rare earth-transition metal magnets in continuous arc rings by hot isostatic pressing. A method includes the steps of compacting rare earth-transition metal powders having a particle size up to 40 microns into radially oriented rings in a mold provided with a radially aligning field, stacking a plurality of compacted radially oriented rings within an annular cavity within a sealed, evacuated cannister to form a cylinder of a predetermined height, subjecting the cannister to temperatures in the range of 900.degree. to 1150.degree. C. under a gas pressure of 15 kpsi to densify the compacts, and cooling the cannister and the compacts to room temperature. An apparatus for performing the above-described method, includes a mold for forming green compacts having a central iron core or mandrel, an outer housing forming an annular space between it and the iron mandrel, plungers for compacting into a ring rare earth-transition metal powder within the annular space, and means for forming a radially oriented magnetic field. The magnetic field forming means includes a pair of electromagnetic coils with bucking fields disposed on opposite axial ends of the annular space. Ferromagnetic paths guide the flux through the inner and outer walls of the mold and through the powder to form a radial field for powder alignment. A cannister is used for forming magnets from the green compacts and the cannister is typically composed of a soft iron that will collapse around the magnets and transmit compressive forces to the green compacts for densification thereof. The cannister includes an annular space for stacking green compacts bounded by inner and outer walls and an evacuation tube. A central mandrel may be provided if a ring magnet having a predetermined inner diameter is desired.

    Abstract translation: 通过热等静压法在连续弧环中形成径向定向稀土 - 过渡金属磁体的装置和方法。 一种方法包括以下步骤:在具有径向对准场的模具中将粒径达40微米的稀土过渡金属粉末压实成径向取向的环,将多个压实的径向取向的环在密封的环形空腔内堆叠 ,抽真空的罐以形成预定高度的圆筒,在15kpsi的气体压力下对罐进行900至1150℃范围内的温度,以使压实体致密化,并将罐和压块冷却至室温 。 一种用于执行上述方法的设备,包括用于形成具有中心铁芯或心轴的生坯的模具,在其与铁芯之间形成环形空间的外壳体,用于压实成环状稀土 - 过渡金属的柱塞 在环形空间内的粉末,以及用于形成径向取向的磁场的装置。 磁场形成装置包括一对电磁线圈,其具有设置在环形空间的相对轴向端部上的屈曲磁场。 铁磁路径引导焊剂通过模具的内壁和外壁,并通过粉末形成用于粉末对准的径向场。 罐用于从生坯中形成磁体,并且罐通常由软铁组成,其将围绕磁体塌陷并将压缩力传递到生坯以使其致密化。 食筒包括用于堆叠由内壁和外壁界定的绿色压块的环形空间和排气管。 如果期望具有预定内径的环形磁体,则可以提供中心心轴。

    Apparatus for differential expansion volume compaction
    6.
    发明授权
    Apparatus for differential expansion volume compaction 失效
    差分膨胀体积压实装置

    公开(公告)号:US4441874A

    公开(公告)日:1984-04-10

    申请号:US206877

    申请日:1980-11-05

    CPC classification number: H01F1/08 B22F3/14 B30B1/005 H01F41/0266

    Abstract: Apparatus for the formation of a molded article from powders and powder compacts of a material by pressure compaction of the powders under the influence of a thermally driven differential volume expansion of first and second elements constraining the powders. The volume expansion achieves a trippling of the compaction effect.

    Abstract translation: 用于通过在受限制粉末的第一和第二元件的热驱动差动体积膨胀的影响下粉末的压力压制来从材料的粉末和粉末压块形成模制品的装置。 体积膨胀实现了压实效应的跳闸。

    Thermal isostatic densifying method and apparatus
    7.
    发明授权
    Thermal isostatic densifying method and apparatus 失效
    热等静压密封方法和装置

    公开(公告)号:US4264556A

    公开(公告)日:1981-04-28

    申请号:US70147

    申请日:1979-08-27

    CPC classification number: B29C43/32 B22F3/04 B22F3/15 B30B11/001

    Abstract: A method and apparatus for thermally isostatically densifying a sample, including placing the sample to be densified into a pressure vessel filled with a thermally expansive pressurizing medium with the medium intermediate the vessel and sample; and varying the thermal energy of the medium to cause it to expand and exert increased pressure to densify the sample.

    Abstract translation: 一种用于热等静化样品的方法和装置,包括将待致密化的样品放置在填充有热膨胀的加压介质的压力容器中,介质介于容器和样品之间; 并改变介质的热能使其膨胀并施加增加的压力以使样品致密化。

    Inflammatory disease model and method of treatment

    公开(公告)号:US09603857B2

    公开(公告)日:2017-03-28

    申请号:US14455605

    申请日:2014-08-08

    Applicant: Kaplesh Kumar

    Inventor: Kaplesh Kumar

    CPC classification number: A61K31/573 A61K31/366 A61K31/616

    Abstract: Model and method of treating inflammatory diseases. Traditional treatments for such diseases include administering to the patient toxic anti-inflammatory drugs. Following stabilization of the symptoms, the drug doses are tapered down to minimize side effects, as a result of which inflammation remains high and the disease is rarely cured. A chemistry-based disease model concludes that irrespective of the role that inflammation plays in the disease, inflammation reduction will impede disease initiation and progression. Managing and controlling inflammatory diseases requires reducing inflammation to acceptable normal values. Non-toxic ways such as non-steroidal anti-inflammatory drugs, anti-inflammatory diets, and regular exercise allow such reduction in inflammation to normal values, thereby slowing down or arresting disease progression and allowing the discontinuation or reduction of toxic anti-inflammatory therapy while maintaining low inflammation using non-toxic therapy.

    Synthesis process for advanced ceramics
    9.
    发明授权
    Synthesis process for advanced ceramics 失效
    先进陶瓷的合成工艺

    公开(公告)号:US5505865A

    公开(公告)日:1996-04-09

    申请号:US869887

    申请日:1992-04-14

    CPC classification number: C04B35/64 C04B35/2658

    Abstract: A process for synthesizing advanced ceramics having superior microstructures and properties. Metal oxide powder particles are produced from solutions of soluble salts of the respective metals by a spray decomposition process. The as-formed powders are heated in an inert atmosphere at a temperature below their sintering temperature and for a time sufficient to cause the oxide powder particles to densify without sintering, and the densified powder is then compacted under high pressure and finally sintered at a temperature above that employed in the initial heating step. Products of this process possess superior magnetic and structural uniformity, excellent grain structure, and very high mechanical strength relative to ceramics prepared without using a heat treatment for densification prior to the compacting step.

    Abstract translation: 一种合成具有优良微结构和性能的先进陶瓷的方法。 金属氧化物粉末颗粒是通过喷雾分解过程由各种金属的可溶性盐的溶液制成的。 将形成的粉末在惰性气氛中在低于其烧结温度的温度下加热足够长的时间,使得氧化物粉末颗粒在不烧结的情况下致密化,然后将致密粉末在高压下压实,最后在温度下烧结 高于在初始加热步骤中使用的。 相对于在压实步骤之前不使用热处理致密化制备的陶瓷,该方法的产品具有优异的磁性和结构均匀性,优异的晶粒结构和非常高的机械强度。

    Samarium-transition metal magnet formation
    10.
    发明授权
    Samarium-transition metal magnet formation 失效
    钐过渡金属磁体形成

    公开(公告)号:US5007972A

    公开(公告)日:1991-04-16

    申请号:US204633

    申请日:1988-06-09

    CPC classification number: H01F1/0556

    Abstract: A process for fabricating high strength Sm.sub.2 TM.sub.17 (TM=transition metal) magnets is disclosed. An alloy is crushed and pulverized to a very fine powder. The powder is aligned in a magnetic field, cold pressed to substantially immobilize the powder particles and then compacted by hot isostatic pressing. The material is either homogenized at this time or prior to crushing. Thereafter, the powder is optimized by an aging heat treatment which includes isothermal exposure followed by controlled cooling. When aging is complete, the compact is magnetized.

    Abstract translation: 公开了制造高强度Sm2TM17(TM =过渡金属)磁体的方法。 将合金粉碎并粉碎成非常细的粉末。 粉末在磁场中排列,冷压以基本上固定粉末颗粒,然后通过热等静压进行压实。 材料在此时或破碎前均匀化。 此后,通过包括等温暴露随后受控冷却的时效热处理来优化粉末。 老化完成后,压实胶被磁化。

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