利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.012 秒)

    Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids
    1.
    发明授权
    Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids 失效
    烷氧基羰基烷基磷脂和烷基氨基羰基烷基磷脂

    公开(公告)号：US4888328A

    公开(公告)日：1989-12-19

    申请号：US166285

    申请日：1988-03-10

    申请人： Nicholas J. Hrib ,  Kirk D. Shoger ,  John J. Tegeler

    发明人： Nicholas J. Hrib ,  Kirk D. Shoger ,  John J. Tegeler

    IPC分类号： A61K31/685 ,  A61P29/00 ,  C07F9/09 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6509 ,  C07F9/6533 ,  C07F9/6544

    CPC分类号： C07F9/6544 ,  C07F9/091 ,  C07F9/5721 ,  C07F9/591 ,  C07F9/650958 ,  C07F9/6533

    摘要： Novel alkoxycarbonylalkylalkylphospholipids and alkylaminocarbonylalkylphospholipids of the formula ##STR1## wherein A.sup.1 is a bivalent radical of the formula --C.sub.m H.sub.2m --wherein m is an integer having a value from 0 to 20, inclusive; A.sup.2 is a bivalent radical of the formula --C.sub.p H.sub.2p --wherein p is an integer having a value from 2 to 6, inclusive; X is a bivalent radial of the formula --O--or --N(R)--wherein R is selected from the group consisting of hydrogen, alkyl radicals having up to 6 carbon atoms, inclusive and phenyl radicals of the formula: ##STR2## where Z and a are as difined in the specification; Y is ##STR3## wherein R.sup.1 is an anlkyl radicals having up to 6 carbon atoms, inclusive and R.sup.2 and R.sup.3 are independently alkyl radicals having up to 6 carbon atoms, inclusive, or taken together with R.sup.1 and the nitrogen atom to which they are attached form a group of the formula ##STR4## wherein r is 0 or 1, and W is oxygen, CH.sub.2, sulfur or N(R.sup.4) wherein R.sup.4 is an alkyl radical having up to 6 carbon atoms, inclusive and aryl; and n is an integer having a value of 3 or 4; processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.

    1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions
    5.
    发明授权
    1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions 失效
    1H-吲哚并[3,2-c]喹啉衍生物，含有它们的组合物，可用于治疗疼痛，精神病或抽搐

    公开(公告)号：US5045539A

    公开(公告)日：1991-09-03

    申请号：US654113

    申请日：1991-02-06

    申请人： Grover C. Helsley ,  John J. Tegeler ,  Kirk D. Shoger

    发明人： Grover C. Helsley ,  John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D471/20

    CPC分类号： C07D471/20

    摘要： There are disclosed compounds having the formula ##STR1## where n is 0, 1, or 2;p and q are each independently 1, 2 or 3;each X and each Y are independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio;R.sub.1 and R.sub.2 are each independently hydrogen or loweralkyl; andR.sub.3 is hydrogen, loweralkyl, loweralkylcarbonyl, arylloweralkyl or aminocarbonyl;which are useful as analgesic, antipsychotic and anticonvulsant agents.

    摘要翻译： 公开了具有式（I）的化合物，其中n为0,1或2; p和q各自独立地为1,2或3; 每个X和每个Y独立地是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，氨基，低级烷基氨基，二低级烷基氨基，三氟甲基或低级烷硫基。 R1和R2各自独立地为氢或低级烷基; 并且R 3是氢，低级烷基，低级烷基羰基，芳基低级烷基或氨基羰基; 其可用作止痛剂，抗精神病药和抗惊厥剂。

    Arylthiadiazolylsulfonamides and derivatives
    6.
    发明授权
    Arylthiadiazolylsulfonamides and derivatives 失效
    芳基噻二唑磺酰胺及其衍生物

    公开(公告)号：US4985450A

    公开(公告)日：1991-01-15

    申请号：US393494

    申请日：1989-08-14

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/08

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; x and y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5, R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.

    摘要翻译： 描述了式为“IMAGE”的化合物，其中n为0,1或2; x和y独立地是氢，低级烷基，低级烷氧基，芳基低级烷基，芳氧基，卤素，-CF 3，-NO 2，-OH，-OCOR 1，其中R 1是低级烷基，芳基低级烷基，芳基或低级烷氧基，R 2是氢，低级烷基或低级烷基羰基 ，R 3为氢或低级烷基，或基团-NR 2 R 3全部为0,1或2，R 4为氢，低级烷基或芳基; 其中R 5和R 6各自独立地为氢或低级烷基，R 7为低级烷基，R 8为氢，低级烷基或芳基，R 9和R 10各自为低级烷基或基团-NR 9 R 10为整体。 R12为氢，低级烷基或芳基，R11为氢，低级烷基或芳基; 其可用于治疗青光眼。

    Arylthiadiazolylsulfonamides and derivatives
    7.
    发明授权
    Arylthiadiazolylsulfonamides and derivatives 失效
    芳基噻二唑磺酰胺及其衍生物

    公开(公告)号：US4873239A

    公开(公告)日：1989-10-10

    申请号：US189919

    申请日：1988-05-03

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/08

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; X and Y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 as a whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5,R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 is loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.

    摘要翻译： 描述了式为“IMAGE”的化合物，其中n为0,1或2; X和Y独立地是氢，低级烷基，低级烷氧基，芳基低级烷基，芳氧基，卤素，-CF 3，-NO 2，-OH，-OCOR 1，其中R 1是低级烷基，芳基低级烷基，芳基或低级烷氧基，R 2是氢，低级烷基或低级烷基羰基 R 3是氢或低级烷基，或者基团-NR 2 R 3整体上是0,1或2，R 4是氢，低级烷基或芳基; 其中R 5和R 6各自独立地为氢或低级烷基，R 7为低级烷基，R 8为氢，低级烷基或芳基，R 9和R 10各自独立地为低级烷基或-NR 9 R 10基团 R12为氢，低级烷基或芳基，R11为氢，低级烷基或芳基; 其可用于治疗青光眼。

    Arylthiadiazolylsulfonamides, pharmaceutical compositions and use
    9.
    发明授权
    Arylthiadiazolylsulfonamides, pharmaceutical compositions and use 失效
    芳基噻二唑磺酰胺，药物组合物和用途

    公开(公告)号：US4758578A

    公开(公告)日：1988-07-19

    申请号：US8225

    申请日：1987-01-29

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/10 ,  A61K31/41 ,  A61K31/433 ,  A61P27/02 ,  A61P27/06 ,  C07D285/08 ,  A61K31/445 ,  C07D413/10

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; X and Y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 as a whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5,R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 is loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.