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64 条记录 (耗时 0.018 秒)

    Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids
    2.
    发明授权
    Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids 失效
    烷氧基羰基烷基磷脂和烷基氨基羰基烷基磷脂

    公开(公告)号：US4888328A

    公开(公告)日：1989-12-19

    申请号：US166285

    申请日：1988-03-10

    申请人： Nicholas J. Hrib ,  Kirk D. Shoger ,  John J. Tegeler

    发明人： Nicholas J. Hrib ,  Kirk D. Shoger ,  John J. Tegeler

    IPC分类号： A61K31/685 ,  A61P29/00 ,  C07F9/09 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6509 ,  C07F9/6533 ,  C07F9/6544

    CPC分类号： C07F9/6544 ,  C07F9/091 ,  C07F9/5721 ,  C07F9/591 ,  C07F9/650958 ,  C07F9/6533

    摘要： Novel alkoxycarbonylalkylalkylphospholipids and alkylaminocarbonylalkylphospholipids of the formula ##STR1## wherein A.sup.1 is a bivalent radical of the formula --C.sub.m H.sub.2m --wherein m is an integer having a value from 0 to 20, inclusive; A.sup.2 is a bivalent radical of the formula --C.sub.p H.sub.2p --wherein p is an integer having a value from 2 to 6, inclusive; X is a bivalent radial of the formula --O--or --N(R)--wherein R is selected from the group consisting of hydrogen, alkyl radicals having up to 6 carbon atoms, inclusive and phenyl radicals of the formula: ##STR2## where Z and a are as difined in the specification; Y is ##STR3## wherein R.sup.1 is an anlkyl radicals having up to 6 carbon atoms, inclusive and R.sup.2 and R.sup.3 are independently alkyl radicals having up to 6 carbon atoms, inclusive, or taken together with R.sup.1 and the nitrogen atom to which they are attached form a group of the formula ##STR4## wherein r is 0 or 1, and W is oxygen, CH.sub.2, sulfur or N(R.sup.4) wherein R.sup.4 is an alkyl radical having up to 6 carbon atoms, inclusive and aryl; and n is an integer having a value of 3 or 4; processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.

    Arylthiadiazolylsulfonamides, pharmaceutical compositions and use
    4.
    发明授权
    Arylthiadiazolylsulfonamides, pharmaceutical compositions and use 失效
    芳基噻二唑磺酰胺，药物组合物和用途

    公开(公告)号：US4758578A

    公开(公告)日：1988-07-19

    申请号：US8225

    申请日：1987-01-29

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/10 ,  A61K31/41 ,  A61K31/433 ,  A61P27/02 ,  A61P27/06 ,  C07D285/08 ,  A61K31/445 ,  C07D413/10

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; X and Y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 as a whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5,R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 is loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.

    1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions
    5.
    发明授权
    1H-indolo[3,2-c]quinoline-derivatives, compositions containing same, useful for treating pain, psychosis or convulsions 失效
    1H-吲哚并[3,2-c]喹啉衍生物，含有它们的组合物，可用于治疗疼痛，精神病或抽搐

    公开(公告)号：US5045539A

    公开(公告)日：1991-09-03

    申请号：US654113

    申请日：1991-02-06

    申请人： Grover C. Helsley ,  John J. Tegeler ,  Kirk D. Shoger

    发明人： Grover C. Helsley ,  John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D471/20

    CPC分类号： C07D471/20

    摘要： There are disclosed compounds having the formula ##STR1## where n is 0, 1, or 2;p and q are each independently 1, 2 or 3;each X and each Y are independently hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, amino, loweralkylamino, diloweralkylamino, trifluoromethyl or loweralkylthio;R.sub.1 and R.sub.2 are each independently hydrogen or loweralkyl; andR.sub.3 is hydrogen, loweralkyl, loweralkylcarbonyl, arylloweralkyl or aminocarbonyl;which are useful as analgesic, antipsychotic and anticonvulsant agents.

    摘要翻译： 公开了具有式（I）的化合物，其中n为0,1或2; p和q各自独立地为1,2或3; 每个X和每个Y独立地是氢，低级烷基，低级烷氧基，卤素，羟基，硝基，氨基，低级烷基氨基，二低级烷基氨基，三氟甲基或低级烷硫基。 R1和R2各自独立地为氢或低级烷基; 并且R 3是氢，低级烷基，低级烷基羰基，芳基低级烷基或氨基羰基; 其可用作止痛剂，抗精神病药和抗惊厥剂。

    Arylthiadiazolylsulfonamides and derivatives
    6.
    发明授权
    Arylthiadiazolylsulfonamides and derivatives 失效
    芳基噻二唑磺酰胺及其衍生物

    公开(公告)号：US4985450A

    公开(公告)日：1991-01-15

    申请号：US393494

    申请日：1989-08-14

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/08

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; x and y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5, R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.

    摘要翻译： 描述了式为“IMAGE”的化合物，其中n为0,1或2; x和y独立地是氢，低级烷基，低级烷氧基，芳基低级烷基，芳氧基，卤素，-CF 3，-NO 2，-OH，-OCOR 1，其中R 1是低级烷基，芳基低级烷基，芳基或低级烷氧基，R 2是氢，低级烷基或低级烷基羰基 ，R 3为氢或低级烷基，或基团-NR 2 R 3全部为0,1或2，R 4为氢，低级烷基或芳基; 其中R 5和R 6各自独立地为氢或低级烷基，R 7为低级烷基，R 8为氢，低级烷基或芳基，R 9和R 10各自为低级烷基或基团-NR 9 R 10为整体。 R12为氢，低级烷基或芳基，R11为氢，低级烷基或芳基; 其可用于治疗青光眼。

    Arylthiadiazolylsulfonamides and derivatives
    7.
    发明授权
    Arylthiadiazolylsulfonamides and derivatives 失效
    芳基噻二唑磺酰胺及其衍生物

    公开(公告)号：US4873239A

    公开(公告)日：1989-10-10

    申请号：US189919

    申请日：1988-05-03

    申请人： John J. Tegeler ,  Kirk D. Shoger

    发明人： John J. Tegeler ,  Kirk D. Shoger

    IPC分类号： C07D285/08

    CPC分类号： C07D285/08

    摘要： There are described compounds of the formula ##STR1## where n is 0, 1 or 2; X and Y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF.sub.3, --NO.sub.2, --OH, --OCOR.sub.1, ##STR2## where R.sub.1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R.sub.2 is hydrogen, loweralkyl or loweralkylcarbonyl, R.sub.3 is hydrogen or loweralkyl, or the group --NR.sub.2 R.sub.3 as a whole is ##STR3## m is 0, 1 or 2, and R.sub.4 is hydrogen, loweralkyl or aryl; and Z is (R.sub.5,R.sub.6), ##STR4## where R.sub.5 and R.sub.6 are each independently hydrogen or loweralkyl, R.sub.7 is loweralkyl, R.sub.8 is hydrogen, loweralkyl or aryl, R.sub.9 and R.sub.10 are each independently loweralkyl or the group --NR.sub.9 R.sub.10 as a whole is ##STR5## R.sub.12 being hydrogen, loweralkyl or aryl, and R.sub.11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.

    摘要翻译： 描述了式为“IMAGE”的化合物，其中n为0,1或2; X和Y独立地是氢，低级烷基，低级烷氧基，芳基低级烷基，芳氧基，卤素，-CF 3，-NO 2，-OH，-OCOR 1，其中R 1是低级烷基，芳基低级烷基，芳基或低级烷氧基，R 2是氢，低级烷基或低级烷基羰基 R 3是氢或低级烷基，或者基团-NR 2 R 3整体上是0,1或2，R 4是氢，低级烷基或芳基; 其中R 5和R 6各自独立地为氢或低级烷基，R 7为低级烷基，R 8为氢，低级烷基或芳基，R 9和R 10各自独立地为低级烷基或-NR 9 R 10基团 R12为氢，低级烷基或芳基，R11为氢，低级烷基或芳基; 其可用于治疗青光眼。