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公开(公告)号：US07776910B2
公开(公告)日：2010-08-17
申请号：US11983347
申请日：2007-11-08
IPC分类号： A61K31/40 , A61K31/404 , C07D207/04 , C07D403/12
CPC分类号： C07D207/36 , C07D207/08 , C07D207/48 , C07D403/12
摘要： Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.
摘要翻译： 式I化合物：其中m，n，Ar，R 1和R 2如本文所定义。 公开了制备化合物和使用该化合物的方法。
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公开(公告)号：US07056903B2
公开(公告)日：2006-06-06
申请号：US10434809
申请日：2003-05-09
申请人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
发明人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
IPC分类号： A61K31/60 , A01N37/36 , C07C315/00 , C07C229/00 , C07C205/00
CPC分类号： C07D263/56 , C07C271/22 , C07C311/08 , C07C311/21 , C07D209/08 , C07D215/14 , C07D235/18 , C07D307/12 , C07D307/80 , C07D405/14 , C07D409/04
摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3， 各自独立地为芳基或杂芳基; R 4是-COOH或四唑基; A，B，m，n和r如说明书中所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。
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公开(公告)号：US20120252777A1
公开(公告)日：2012-10-04
申请号：US13429484
申请日：2012-03-26
申请人： Johannes Cornelius Hermann , Lee Edwin Lowrie, JR. , Matthew C. Lucas , Kin-Chun Thomas Luk , Fernando Padilla , Jutta Wanner , Wenwei Xie , Xiaohu Zhang
发明人： Johannes Cornelius Hermann , Lee Edwin Lowrie, JR. , Matthew C. Lucas , Kin-Chun Thomas Luk , Fernando Padilla , Jutta Wanner , Wenwei Xie , Xiaohu Zhang
IPC分类号： A61K31/519 , A61K31/551 , A61K31/5386 , A61P29/00 , A61P37/00 , A61P19/04 , A61P25/00 , A61P17/06 , A61P3/10 , A61P37/06 , A61P35/00 , A61P11/06 , A61P17/00 , A61P1/04 , A61P1/00 , A61P25/28 , A61P35/02 , C07D513/04
CPC分类号： C07D513/04 , A61K45/06
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型吡咯并吡嗪衍生物的用途：其中所有可变取代基如本文所述定义，其是SYK抑制剂，并且可用于治疗自身免疫和炎性疾病。
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公开(公告)号：US07754759B2
公开(公告)日：2010-07-13
申请号：US11592685
申请日：2006-11-03
申请人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Lee Edwin Lowrie, Jr. , Dov Nitzan , Shu-Hai Zhao
发明人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Lee Edwin Lowrie, Jr. , Dov Nitzan , Shu-Hai Zhao
IPC分类号： A61K31/353 , C07D311/22 , C07D311/58
CPC分类号： C07D311/22 , C07D311/58 , C07D405/06
摘要： Compounds of the formula I: wherein m, n, p, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Methods of making the compounds and using the compounds for treatment of 5-HT6 receptor-mediated diseases are disclosed.
摘要翻译： 式I化合物：其中m，n，p，X，Ar，R 1，R 2，R 3，R 4和R 5如本文所定义。 公开了制备化合物和使用该化合物治疗5-HT6受体介导的疾病的方法。
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公开(公告)号：US07312230B2
公开(公告)日：2007-12-25
申请号：US11240547
申请日：2005-09-30
申请人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
发明人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
IPC分类号： A61K31/44 , A61K31/435 , C07D215/38 , C07D215/00 , C07D215/02
CPC分类号： C07D263/56 , C07C271/22 , C07C311/08 , C07C311/21 , C07D209/08 , C07D215/14 , C07D235/18 , C07D307/12 , C07D307/80 , C07D405/14 , C07D409/04
摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3， 各自独立地为芳基或杂芳基; R 4是-COOH或四唑基; A，B，m，n和r如说明书中所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。
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公开(公告)号：US06693098B2
公开(公告)日：2004-02-17
申请号：US09810436
申请日：2001-03-14
申请人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
发明人： Richard Leo Cournoyer , Paul Francis Keitz , Lee Edwin Lowrie, Jr. , Alexander Victor Muehldorf , Counde O'Yang , Dennis Mitsugu Yasuda
IPC分类号： A61K31495
CPC分类号： C07D263/56 , C07C271/22 , C07C311/08 , C07C311/21 , C07D209/08 , C07D215/14 , C07D235/18 , C07D307/12 , C07D307/80 , C07D405/14 , C07D409/04
摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3各自独立地在每个出现的芳基或杂芳基中; R 4， 是-COOH或四唑基; A，B，m，n和r如说明书中所定义;或各异构体，异构体的外消旋或非外消旋混合物或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。
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公开(公告)号：US08921383B2
公开(公告)日：2014-12-30
申请号：US13429484
申请日：2012-03-26
申请人： Johannes Cornelius Hermann , Lee Edwin Lowrie, Jr. , Matthew C. Lucas , Kin-Chun Thomas Luk , Fernando Padilla , Jutta Wanner , Wenwei Xie , Xiaohu Zhang
发明人： Johannes Cornelius Hermann , Lee Edwin Lowrie, Jr. , Matthew C. Lucas , Kin-Chun Thomas Luk , Fernando Padilla , Jutta Wanner , Wenwei Xie , Xiaohu Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D471/00 , C07D487/00 , C07D513/04 , A61K45/06
CPC分类号： C07D513/04 , A61K45/06
摘要： The present invention relates to the use of novel thiazolopyrimidine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译： 本发明涉及式I的新型噻唑并嘧啶衍生物的用途：其中所有可变取代基如本文所述定义，其为SYK抑制剂，并且可用于治疗自身免疫和炎性疾病。
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