Argon-based inhalable gaseous medicinal product for the treatment of neurointoxications
    6.
    发明申请
    Argon-based inhalable gaseous medicinal product for the treatment of neurointoxications 审中-公开
    氩气可吸入气体药物治疗神经毒素

    公开(公告)号:US20050152988A1

    公开(公告)日:2005-07-14

    申请号:US11007684

    申请日:2004-12-08

    CPC classification number: A61K33/00

    Abstract: The invention relates to the use of argon (Ar) gas for producing all or part of an inhalable medicinal product intended to prevent or treat a neurointoxication in humans. The medicinal product contains argon in an effective proportion and acts on at least one brain receptor in order to regulate the functioning of dopamine-, glutamate-, serotonin-, acetylcholine-, taurine-, GABA- and/or noradrenalin-mediated neuro-transmission systems. Preferably, the proportion by volume of argon in the gaseous medicinal product is between 15 and 80%. The neurointoxication is chosen from excitotoxicities engendering a state of addiction, acute cerebral accidents, neurodegenerative diseases, and psychiatric or neurological pathologies, in particular anxiety conditions, psychotic conditions, in particular schizophrenia, and epilepsy in its various forms.

    Abstract translation: 本发明涉及氩(Ar)气用于生产旨在预防或治疗人类神经毒素的全部或部分可吸入药物的用途。 药用产品含有有效比例的氩气,作用于至少一种脑受体,以调节多巴胺,谷氨酸,5-羟色胺,乙酰胆碱,牛磺酸,GABA和/或去甲肾上腺素介导的神经传递的功能 系统。 优选地,气态医药产品中的氩气体积比例为15-80%。 神经排毒选自产生成瘾状态,急性脑意外,神经变性疾病,精神病学或神经病理学,特别是焦虑症,精神病状况,特别是精神分裂症和各种形式的癫痫的兴奋性毒性。

    Method of separating isomers of a crown ether compound to recover
cis-syn-cis isomer from dicyclohexyl 18-crown 6.
    10.
    发明授权
    Method of separating isomers of a crown ether compound to recover cis-syn-cis isomer from dicyclohexyl 18-crown 6. 失效
    分离异氰酸酯化合物的异构体从DICYCLOHEXYL 18-CROWN 6中回收CIS-SYN-CIS异构体的方法。

    公开(公告)号:US5082955A

    公开(公告)日:1992-01-21

    申请号:US625552

    申请日:1990-12-11

    CPC classification number: C07D323/00

    Abstract: A method for separating the isomers of a crown ether compound and making it possible to recover in particular the pure cis-syn-cis isomer from DCH 18C6 includes:a) dissolving in an organic solvent a mixture of the isomers of said crown compound including the cis-anti-cis isomer and the cis-syn-cis isomer,b) adding uranyl nitrate to the solution obtained in stage a) in sufficient quantities so that virtually all of the isomers, except the cis-syn-cis isomer, are precipitated in the form of complexes with the uranyl nitrate,c) separating the formed precipitate,d) recovering the cis-syn-cis isomer from the solution, ande) recovering the cis-anti-cis isomer from the precipitate.

    Abstract translation: 用于分离冠醚化合物的异构体并且使得有可能特别从DCH 18C6中回收纯顺式顺式顺式异构体的方法包括:a)将有机溶剂的所述冠化合物的异构体的混合物溶解在包含 顺式 - 顺式 - 顺式异构体和顺 - 顺 - 顺式异构体,b)将足够量的a)中得到的溶液中加入硝酸铀,使得实际上所有异构体(顺式 - 顺 - 顺式异构体除外)均沉淀 以与硝酸铀酰的络合物形式,c)分离所形成的沉淀物,d)从溶液中回收顺式 - 顺 - 顺式异构体,和e)从沉淀物中回收顺 - 顺 - 顺式异构体。

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