公开(公告)号：US08263347B2

公开(公告)日：2012-09-11

申请号：US12738684

申请日：2008-10-20

申请人： Hirohito Tsubouchi ,  Hirofumi Uto ,  Takeshi Okanoue ,  Yo-ichi Ishida ,  Yuko Sato ,  Masayuki Sudo

发明人： Hirohito Tsubouchi ,  Hirofumi Uto ,  Takeshi Okanoue ,  Yo-ichi Ishida ,  Yuko Sato ,  Masayuki Sudo

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2333/8139 ,  G01N2800/085

摘要： Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides thereof (sequence A: position-440 to position-456, sequence B: position-439 to position-456, and sequence C: position-438 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established. The use of a combination of a kininogen-based marker and a C4-based marker (the full length sequence or partial peptides thereof) enables identification of chronic hepatitis and an asymptomatic virus carrier, as well as non-alcoholic fatty liver disease.

摘要翻译： 公开了一种用于诊断肝脏疾病的标志物，其可以以简单的方式确定疾病; 针对标记的抗体; 诊断剂; 诊断方法; 以及血液或血清中标记物检测的方法。 蛋白质组分析显示，全长激肽原及其三个部分肽（序列A：位置440至位置-456，序列B：位置-439至位置-456，序列C：位置-438至位置-456） ）与非酒精性脂肪性肝病患者的血清显着不同于健康人血清; 并建立了可以方便地用于体格检查的非酒精性脂肪肝疾病的诊断剂和检测方法。 使用基于激肽原的标记物和基于C4的标记物（其全长序列或其部分肽）的组合能够鉴定慢性肝炎和无症状病毒载体以及非酒精性脂肪肝疾病。

公开(公告)号：US20110281271A1

公开(公告)日：2011-11-17

申请号：US13130673

申请日：2009-11-26

申请人： Michinori Kohara ,  Masayuki Sudo

发明人： Michinori Kohara ,  Masayuki Sudo

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12N5/071

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2320/11

摘要： The present inventors focused on siE sequences that have been thought to show RNAi activity against HCV viral RNAs, and mainly selected the D5-50 and D5-197 regions present within the IRES region, and carried on the analysis. As a result, the present inventors successfully identified siRNA sequences that exhibit a more effective RNAi activity against hepatitis C virus RNAs. Furthermore, the siRNAs were demonstrated to have a significant inhibitory effect on HCV propagation in an in vivo system.

摘要翻译： 本发明人着重于已被认为显示针对HCV病毒RNA的RNAi活性的siE序列，主要选择存在于IRES区域内的D5-50和D5-197区域，并进行分析。 结果，本发明人成功地鉴定了对丙型肝炎病毒RNA表现出更有效的RNAi活性的siRNA序列。 此外，证实siRNA在体内系统中对HCV繁殖具有显着的抑制作用。

公开(公告)号：US20110129859A1

公开(公告)日：2011-06-02

申请号：US12738684

申请日：2008-10-20

申请人： Hirohito Tsubouchi ,  Hirofumi Uto ,  Takeshi Okanoue ,  Yo-ichi Ishida ,  Yuko Sato ,  Masayuki Sudo

发明人： Hirohito Tsubouchi ,  Hirofumi Uto ,  Takeshi Okanoue ,  Yo-ichi Ishida ,  Yuko Sato ,  Masayuki Sudo

IPC分类号： G01N33/53 ,  C07K7/08 ,  C07K14/435 ,  C07K16/18

CPC分类号： G01N33/6893 ,  G01N2333/8139 ,  G01N2800/085

摘要： Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides thereof (sequence A: position-440 to position-456, sequence B: position-439 to position-456, and sequence C: position-438 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established. The use of a combination of a kininogen-based marker and a C4-based marker (the full length sequence or partial peptides thereof) enables identification of chronic hepatitis and an asymptomatic virus carrier, as well as non-alcoholic fatty liver disease.

摘要翻译： 公开了：用于诊断肝脏疾病的标志物，其可以以简单的方式确定疾病; 针对标记的抗体; 诊断剂; 诊断方法; 以及血液或血清中标记物检测的方法。 蛋白质组分析显示，全长激肽原及其三个部分肽（序列A：位置440至位置-456，序列B：位置-439至位置-456，序列C：位置-438至位置-456） ）与非酒精性脂肪性肝病患者的血清显着不同于健康人血清; 建立了可以方便地用于体格检查的非酒精性脂肪肝疾病的诊断剂和检测方法。 使用基于激肽原的标记物和基于C4的标记物（其全长序列或其部分肽）的组合能够鉴定慢性肝炎和无症状病毒载体以及非酒精性脂肪肝疾病。

公开(公告)号：US07753168B2

公开(公告)日：2010-07-13

申请号：US12227117

申请日：2007-05-16

申请人： Takeshi Hara ,  Hideyuki Komitsu ,  Masayuki Sudo

发明人： Takeshi Hara ,  Hideyuki Komitsu ,  Masayuki Sudo

IPC分类号： F01N1/00 ,  F01N1/08 ,  F01N1/16

CPC分类号： F01N1/166 ,  F01N1/084 ,  F01N1/089 ,  F01N2490/06

摘要： A muffler has a casing with a plurality of sound-muffling chambers, exhaust pipes that pass through at least two sound-muffling chambers and to pass through exhaust from an engine, a plurality of apertures provided in each exhaust pipe, and a plurality of valves provided in each of the apertures. In this muffler, the plurality of apertures are provided at the locations at which an exhaust flow from one aperture and an exhaust flow from another aperture do not interfere with each other. When there are two apertures, the apertures are provided at positions in the exhaust pipes at which the apertures do not face each other. For this reason, by avoiding interference between exhaust flows from the two apertures, it is possible to suppress an abnormal sound caused by the interference.

摘要翻译： 消声器具有壳体，该壳体具有多个声音消音室，排气管通过至少两个声音消声室并且通过来自发动机的排气，设置在每个排气管中的多个孔，以及多个阀 设置在每个孔中。 在这种消音器中，多个孔设置在来自一个孔的排出流和来自另一个孔的排出流不彼此干涉的位置处。 当存在两个孔时，孔被设置在排气管中的孔不彼此面对的位置处。 为此，通过避免来自两个孔的排出流之间的干扰，可以抑制由干涉引起的异常声音。

公开(公告)号：US20060128617A1

公开(公告)日：2006-06-15

申请号：US10543078

申请日：2004-01-23

申请人： Michinori Kohara ,  Tsunamasa Watanabe ,  Kazunari Taira ,  Makoto Miyagishi ,  Masayuki Sudo

发明人： Michinori Kohara ,  Tsunamasa Watanabe ,  Kazunari Taira ,  Makoto Miyagishi ,  Masayuki Sudo

IPC分类号： A61K38/16 ,  A61K48/00 ,  C07H21/02 ,  C12Q1/70 ,  C12N15/86 ,  C07K14/18

CPC分类号： C12N15/1131 ,  A61K31/7105 ,  A61K38/00 ,  C12N2310/3181

摘要： A method of inhibiting the replication ability of a hepatitis C virus (HCV) is provided. An oligoribonucleotide or a peptide nucleic acid which sequence-specifically binds to the HCV-RNA, and a therapeutic agent for hepatitis C which contains any of these components as an active ingredient are provided.

摘要翻译： 提供了抑制丙型肝炎病毒（HCV）的复制能力的方法。 提供了序列特异性结合HCV-RNA的寡核糖核苷酸或肽核酸，以及含有任何这些成分作为活性成分的丙型肝炎治疗剂。

公开(公告)号：US4857796A

公开(公告)日：1989-08-15

申请号：US137577

申请日：1987-12-24

申请人： Yasunobu Amano ,  Masayuki Sudo

发明人： Yasunobu Amano ,  Masayuki Sudo

IPC分类号： H01J29/50 ,  H01J29/51 ,  H01J29/56 ,  H01J29/70

CPC分类号： H01J29/707

摘要： A cathode-ray tube which has an electron gun and a correcting unit with a magnetic device electrically coupled to a final electrode of the electron gun so as to selectively apply a uniform magnetic field to required ones of a plurality of electron beams, so as to thereby correct the path of a selected electron beam without causing distortion in the shape of the beam spot.

摘要翻译： 一种阴极射线管，其具有电子枪和具有与电子枪的最终电极电耦合的磁性装置的校正单元，以选择性地对多个电子束中的所需电子束施加均匀的磁场，以便 从而校正所选择的电子束的路径，而不会造成束斑形状的变形。

公开(公告)号：US08183005B1

公开(公告)日：2012-05-22

申请号：US11659779

申请日：2005-08-11

申请人： Masayuki Sudo ,  Hiroshi Sakamoto

发明人： Masayuki Sudo ,  Hiroshi Sakamoto

IPC分类号： C12Q1/48 ,  C12Q1/00

CPC分类号： C07D307/54 ,  A61K31/00 ,  A61K31/137 ,  A61K31/165 ,  A61K31/198 ,  A61K31/225 ,  A61K31/381 ,  A61K31/405 ,  A61K31/7088 ,  C07D209/20 ,  C07D213/55 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2770/24211 ,  C12Y203/0105

摘要： The present inventors examined the inhibitory activity against HCV replicon of myriocin, fumonisin B1, and ceramide trafficking inhibitor HPA-12, which are compounds derived from microorganisms such as those of the genus Aureobasidium, and found that these compounds have the effect of inhibiting the replication of HCV replicon RNAs or inhibiting the expression of HCV proteins. The present inventors further performed serine palmitoyltransferase knockdown experiments using siRNAs, and results showed that HCV replicon activity and HCV protein expression were significantly inhibited in cells with suppressed LCB1 expression. Thus, sphingolipid biosynthesis was found to be involved in HCV infection. This showed that HCV infection can be treated or prevented by inhibiting enzyme activities involved in the process of sphingolipid biosynthesis by adding compounds or knocking down a gene.

摘要翻译： 本发明人检测了对来自微生物（Aureobasidium）的微生物衍生的化合物的Myriocin，伏马菌素B1和神经酰胺运送抑制剂HPA-12的HCV复制子的抑制活性，发现这些化合物具有抑制复制的作用 的HCV复制子RNA或抑制HCV蛋白的表达。 本发明人进一步使用siRNA进行丝氨酸棕榈酰转移酶敲除实验，结果表明，在具有抑制的LCB1表达的细胞中HCV复制子活性和HCV蛋白表达被显着抑制。 因此，发现鞘脂生物合成涉及HCV感染。 这表明通过添加化合物或敲低基因，可以通过抑制鞘脂生物合成过程中涉及的酶活性来治疗或预防HCV感染。

公开(公告)号：US4933598A

公开(公告)日：1990-06-12

申请号：US439004

申请日：1989-11-21

申请人： Masayuki Sudo ,  Tomohisa Uba ,  Yasunobu Amano ,  Kazuo Omae ,  Akira Nakayama ,  Yoshiro Ishikawa ,  Ichiro Iwaki

发明人： Masayuki Sudo ,  Tomohisa Uba ,  Yasunobu Amano ,  Kazuo Omae ,  Akira Nakayama ,  Yoshiro Ishikawa ,  Ichiro Iwaki

IPC分类号： H01J29/51 ,  H01J29/92

CPC分类号： H01J29/92 ,  H01J29/51

摘要： A cathode-ray tube in which outer convergence plates as constituents of the convergence plate assembly in the electron gun are supplied with individual voltages so that the horizontal misconvergence at the center portion and at the peripheral portions of the screen are positively corrected and in the arrangement the anode button is provided with a plurality of voltage supply pins. Further, the end portions of the two lead wires which are introduced form the anode button are opened outwardly so that the lead wires are prevented from coming in contact with the bead glass.

摘要翻译： 作为电子枪中的会聚板组件的组成的外侧会聚板被提供有各自的电压的阴极射线管，使得屏幕的中央部分和周边部分处的水平失会聚积极校正，并且在布置 阳极按钮设置有多个电压供给销。 此外，从阳极按钮引入的两根引线的端部向外打开，从而防止引线与珠缘玻璃接触。

公开(公告)号：US08957199B2

公开(公告)日：2015-02-17

申请号：US13130673

申请日：2009-11-26

申请人： Michinori Kohara ,  Masayuki Sudo

发明人： Michinori Kohara ,  Masayuki Sudo

IPC分类号： C07H21/04 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2320/11

摘要： The present inventors focused on siE sequences that have been thought to show RNAi activity against HCV viral RNAs, and mainly selected the D5-50 and D5-197 regions present within the IRES region, and carried on the analysis. As a result, the present inventors successfully identified siRNA sequences that exhibit a more effective RNAi activity against hepatitis C virus RNAs. Furthermore, the siRNAs were demonstrated to have a significant inhibitory effect on HCV propagation in an in vivo system.

摘要翻译： 本发明人着重于已被认为显示针对HCV病毒RNA的RNAi活性的siE序列，主要选择存在于IRES区域内的D5-50和D5-197区域，并进行分析。 结果，本发明人成功地鉴定了对丙型肝炎病毒RNA表现出更有效的RNAi活性的siRNA序列。 此外，证实siRNA在体内系统中对HCV繁殖具有显着的抑制作用。

公开(公告)号：US20090229912A1

公开(公告)日：2009-09-17

申请号：US12227117

申请日：2007-05-16

申请人： Takeshi Hara ,  Hideyuki Komitsu ,  Masayuki Sudo

发明人： Takeshi Hara ,  Hideyuki Komitsu ,  Masayuki Sudo

IPC分类号： F01N1/00

CPC分类号： F01N1/166 ,  F01N1/084 ,  F01N1/089 ,  F01N2490/06

摘要： A muffler has a casing with a plurality of sound-muffling chambers, exhaust pipes that pass through at least two sound-muffling chambers and to pass through exhaust from an engine, a plurality of apertures provided in each exhaust pipe, and a plurality of valves provided in each of the apertures. In this muffler, the plurality of apertures are provided at the locations at which an exhaust flow from one aperture and an exhaust flow from another aperture do not interfere with each other. When there are two apertures, the apertures are provided at positions in the exhaust pipes at which the apertures do not face each other. For this reason, by avoiding interference between exhaust flows from the two apertures, it is possible to suppress an abnormal sound caused by the interference.

摘要翻译： 消声器具有壳体，该壳体具有多个声音消音室，排气管通过至少两个声音消声室并且通过来自发动机的排气，设置在每个排气管中的多个孔，以及多个阀 设置在每个孔中。 在这种消音器中，多个孔设置在来自一个孔的排出流和来自另一个孔的排出流不彼此干涉的位置处。 当存在两个孔时，孔被设置在排气管中的孔不彼此面对的位置处。 为此，通过避免来自两个孔的排出流之间的干扰，可以抑制由干涉引起的异常声音。