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公开(公告)号：US20070054336A1
公开(公告)日：2007-03-08
申请号：US11476254
申请日：2006-06-27
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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公开(公告)号：US20160222070A1
公开(公告)日：2016-08-04
申请号：US14849531
申请日：2015-09-09
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07927610B2
公开(公告)日：2011-04-19
申请号：US11929022
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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4.发明申请Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method 审中-公开基于微阵列的单核苷酸多态性，测序和基因表达测定方法公开(公告)号：US20060240443A1
公开(公告)日：2006-10-26
申请号：US11110630
申请日：2005-04-20
申请人： Michael Lodes , Dominic Suciu , Andy McShea
发明人： Michael Lodes , Dominic Suciu , Andy McShea
CPC分类号： C12Q1/6874
摘要： There is disclosed a microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method. Specifically, there is disclosed a method using a microarray device wherein a plurality of hybridized structures is formed by contacting the microarray under a hybridizing condition to a hybridizing solution comprising a plurality of tagged targets and a plurality of detection sequences. The detection sequences of each hybridized structure is extended using an extension-ligation solution and an extension-ligation condition. After extension, ligation of the extended sequence occurs to a probe if the terminal nucleotide of a probe is complementary to the hybridized tagged targets. Non-bound material is removed by using a washing solution and a washing method. The target nucleotide and the target sequence of the tagged targets is determined by which probe is ligated to the detection sequences.
摘要翻译： 公开了基于微阵列的单核苷酸多态性，测序和基因表达测定方法。 具体地，公开了使用微阵列装置的方法，其中通过在杂交条件下将微阵列与包含多个标记的靶和多个检测序列的杂交溶液接触而形成多个杂交结构。 使用延伸连接溶液和延伸连接条件扩展每个杂交结构的检测序列。 延伸后，如果探针的末端核苷酸与杂交标记的靶标互补，则延伸序列的连接发生在探针上。 通过使用洗涤溶液和洗涤方法除去未结合的物质。 通过将哪个探针连接到检测序列来确定标记的靶标的靶核苷酸和靶序列。
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公开(公告)号：US07087713B2
公开(公告)日：2006-08-08
申请号：US09793306
申请日：2001-02-26
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US07935353B2
公开(公告)日：2011-05-03
申请号：US11476254
申请日：2006-06-27
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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公开(公告)号：US20070059742A1
公开(公告)日：2007-03-15
申请号：US11499230
申请日：2006-08-03
申请人： Axel Stover , Andy McShea , Michael Lodes , Kristian Roth , Kevin Schwarzkopf
发明人： Axel Stover , Andy McShea , Michael Lodes , Kristian Roth , Kevin Schwarzkopf
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00693 , B01J2219/00722 , C40B50/14
摘要： Disclosed herein is a process for stripping oligonucleotide target from a microarray to allow reuse of the microarray. The process comprises providing a microarray having probe oligonucleotides attached thereto and target oligonucleotides hybridized to the probe oligonucleotides. The microarray is then incubated with a formulation comprising an organic solvent and an organic base. The target oligonucleotides are substantially removed from the microarray by the formulation. Alternatively, prior to or after incubation of the microarray with the formulation, the microarray may be contacted to an aqueous solution of a base to improve the efficiency of removal of the target oligonucleotides.
摘要翻译： 本文公开了一种从微阵列中剥离寡核苷酸靶标以允许重新利用微阵列的方法。 该方法包括提供具有与其连接的探针寡核苷酸的微阵列和与探针寡核苷酸杂交的靶寡核苷酸。 然后将微阵列与包含有机溶剂和有机碱的制剂一起温育。 目标寡核苷酸通过制剂基本上从微阵列中除去。 或者，在微阵列与制剂孵育之前或之后，微阵列可以与碱的水溶液接触以提高靶寡核苷酸的去除效率。
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公开(公告)号：US20110142871A1
公开(公告)日：2011-06-16
申请号：US11928957
申请日：2007-10-30
IPC分类号： A61K39/04 , C07K14/35 , C07H21/04 , C12N15/75 , C12N1/21 , A61K38/16 , A61K31/711 , C12P21/02 , A61P31/06 , A61P37/04
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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公开(公告)号：US20090022742A1
公开(公告)日：2009-01-22
申请号：US11929022
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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公开(公告)号：US20070141087A1
公开(公告)日：2007-06-21
申请号：US11505569
申请日：2006-08-16
申请人： Steven Reed , Yasir Skeiky , Davin Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas Vedvick , Daniel Twardzik , Michael Lodes , Ronald Hendrickson
发明人： Steven Reed , Yasir Skeiky , Davin Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas Vedvick , Daniel Twardzik , Michael Lodes , Ronald Hendrickson
CPC分类号： C12Q1/6883 , A61K39/00 , C07K14/35 , C07K16/1289 , C07K2319/00 , C12Q1/689 , G01N33/5695
摘要： Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断结核病的化合物和方法。 提供的化合物包括含有一种或多种结核分枝杆菌蛋白质的至少一个抗原部分的多肽和编码这种多肽的DNA序列。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的结核分枝杆菌感染。 还提供了针对这种多肽的抗体。
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