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公开(公告)号：US10792302B2
公开(公告)日：2020-10-06
申请号：US16079498
申请日：2017-02-24
Applicant: Noster Inc.
Inventor： Ikuo Kimura , Kenji Yamamoto , Keiko Hisa
IPC: A61K31/715 , A61K35/744 , A23L33/10 , A23K10/16 , A23K20/163 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A23L29/269 , A23L33/135
Abstract: The present invention provides a prophylactic or therapeutic composition for a metabolic disorder, a composition for amplifying the amount of short-chain fatty acid in the intestine, or a composition for decreasing a ratio of bacteria belonging to the Firmicutes to bacteria belonging to the Bacteroidetes in the intestine, each containing an exopolysaccharide produced by Leuconostoc mesenteroides, and further, a food, a pharmaceutical product, a feed and the like containing the composition.
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公开(公告)号：US11337947B2
公开(公告)日：2022-05-24
申请号：US16494661
申请日：2018-02-23
Applicant: NOSTER INC.
Inventor： Hidenori Matsui , Marina Kawaguchi
IPC: A61K31/201 , C07K14/205 , A61K38/00
Abstract: The present invention provides a composition for inhibiting proliferation of a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative, which contains a fatty acid having 18 carbon atoms and a hydroxyl group at the 10-position as an active ingredient. Furthermore, the present invention provides a composition for preventing or treating a disease caused by a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative.
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公开(公告)号：US11123324B2
公开(公告)日：2021-09-21
申请号：US16326127
申请日：2017-08-17
Inventor： Reiko Shinkura , Kota Yamamoto
IPC: A61K31/365 , A61K31/407 , A61P37/08 , A61K45/00 , A61P11/06 , A61P27/02 , A61P43/00 , A61P17/00 , A61P37/02 , A61P17/04 , A61P11/02 , A61K39/39 , A61P1/04
Abstract: The present invention provides a pharmaceutical composition to be used for the treatment or prophylaxis of allergic diseases. More specifically, the present invention provides a pharmaceutical composition to be used for the treatment or prophylaxis of allergic diseases, which contains a substance that induces selective IgA class switching in B cells. As a substance that induces selective IgA class switching in B cells, a PKC activator can be used. In addition, a composition containing a substance that induces selective IgA class switching in B cells can also be useful as a mucosal adjuvant.
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公开(公告)号：US20210285020A1
公开(公告)日：2021-09-16
申请号：US17337201
申请日：2021-06-02
Applicant: Kyoto University , Noster, Inc.
Inventor： Jun OGAWA , Shigenobu KISHINO , Teruo KAWADA , Nobuyuki TAKAHASHI , Tsuyoshi GOTO , Yasunori YONEJIMA
Abstract: The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from Lactobacillus and using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.
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公开(公告)号：US11046980B2
公开(公告)日：2021-06-29
申请号：US16404241
申请日：2019-05-06
Applicant: KYOTO UNIVERSITY , Noster Inc.
Inventor： Jun Ogawa , Shigenobu Kishino , Teruo Kawada , Nobuyuki Takahashi , Tsuyoshi Goto , Yasunori Yonejima
Abstract: The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from Lactobacillus and using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.
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Patent Agency Ranking
公开(公告)号：US20230285343A1
公开(公告)日：2023-09-14
申请号：US17732057
申请日：2022-04-28
Applicant: NOSTER INC.
Inventor： Hidenori Matsui , Marina Kawaguchi
IPC: A61K31/201 , C07K14/205
CPC classification number: A61K31/201 , C07K14/205 , A61K38/00
Abstract: The present invention provides a composition for inhibiting proliferation of a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative, which contains a fatty acid having 18 carbon atoms and a hydroxyl group at the 10-position as an active ingredient. Furthermore, the present invention provides a composition for preventing or treating a disease caused by a bacterium provided with a menaquinone synthesis route via futalosine or a futalosine derivative.
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公开(公告)号：US11130974B2
公开(公告)日：2021-09-28
申请号：US16642282
申请日：2018-08-30
Applicant: KYOTO UNIVERSITY , Noster Inc.
Inventor： Jun Ogawa , Shigenobu Kishino , Kohey Kitao
IPC: C12P7/64 , C07C69/732
Abstract: The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.
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公开(公告)号：US10975397B2
公开(公告)日：2021-04-13
申请号：US16369271
申请日：2019-03-29
Applicant: KYOTO UNIVERSITY , Noster Inc.
Inventor： Jun Ogawa , Shigenobu Kishino , Sakayu Shimizu , Yasunori Yonejima
Abstract: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from Lactobacillus plantarum including lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.
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公开(公告)号：US11730772B2
公开(公告)日：2023-08-22
申请号：US16968376
申请日：2019-02-08
Applicant: NOSTER INC.
Inventor： Tomoya Yamashita , Takuo Emoto , Naofumi Yoshida
IPC: A01N63/00 , A61K35/74 , A23L33/135 , C12N1/20
CPC classification number: A61K35/74 , A23L33/135 , C12N1/20
Abstract: The present invention provides a combination containing (1) a composition containing a live bacterium of Bacteroides vulgatus isolated from nature, and (2) a composition containing a live bacterium of Bacteroides dorei isolated from nature.
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公开(公告)号：US20220367021A1
公开(公告)日：2022-11-17
申请号：US17621856
申请日：2021-07-30
Applicant: Noster Inc.
Inventor： Kohey KITAO
Abstract: A system that stores bacterial flora of donors, selects a bacterium necessary for improving bacterial flora according to the health condition of a test subject, and supplies the same in a utilizable state to the test subject is provided.
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