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15 条记录 (耗时 0.019 秒)

    5,6-dimethylthieno[2,3-di] pyrimidine derivatives, the preparation method thereof and the pharmaceutical composition comprising the same for anti-virus
    3.
    发明授权
    5,6-dimethylthieno[2,3-di] pyrimidine derivatives, the preparation method thereof and the pharmaceutical composition comprising the same for anti-virus 有权
    5,6-二甲基噻吩并[2,3-d]嘧啶衍生物，其制备方法和包含其的药物组合物用于抗病毒

    公开(公告)号：US07816351B2

    公开(公告)日：2010-10-19

    申请号：US12067246

    申请日：2005-09-23

    申请人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

    发明人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

    IPC分类号： A61K31/5377 ,  C07D413/14

    CPC分类号： C07D495/04

    摘要： Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C.

    摘要翻译： 本文公开了可用作抗病毒剂的5'，bgr-二甲基噻吩并[2,3-d]嘧啶衍生物。 更具体地，公开了具有对丙型肝炎病毒（HCV）增殖具有优异抑制作用的式1表示的5α-二甲基噻吩并[2,3-d]嘧啶衍生物，其药学上可接受的盐，其制备方法和 用于预防和治疗丙型肝炎病毒（HCV）的药物组合物，其含有这些化合物作为活性成分。 由式1表示的5,6-二甲基噻吩并[2,3-d]嘧啶衍生物具有抑制丙型肝炎病毒增殖并且毒性低的优异效果。 因此，这些化合物可用作预防和治疗丙型肝炎的药剂。

    5,6-Dimethylthieno[2,3-Di] Pyrimidine Derivatives, the Preparation Method Thereof and the Pharmaceutical Composition Comprising the Same for Anti-Virus
    4.
    发明申请
    5,6-Dimethylthieno[2,3-Di] Pyrimidine Derivatives, the Preparation Method Thereof and the Pharmaceutical Composition Comprising the Same for Anti-Virus 有权
    5,6-二甲基噻吩并[2,3-d]嘧啶衍生物及其制备方法和包含其的药物组合物

    公开(公告)号：US20080234482A1

    公开(公告)日：2008-09-25

    申请号：US12067246

    申请日：2005-09-23

    申请人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

    发明人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C.

    摘要翻译： 本文公开了可用作抗病毒剂的5β-二甲基噻吩并[2,3-d]嘧啶衍生物。 更具体地，公开了5种由式1表示的β-二甲基噻吩并[2,3-d]嘧啶衍生物，其对丙型肝炎病毒（HCV）的增殖具有优异的抑制作用，其药学上可接受的盐，其制备方法和 用于预防和治疗丙型肝炎病毒（HCV）的药物组合物，其含有作为活性成分的这些化合物。 由式1表示的5,6-二甲基噻吩并[2,3-d]嘧啶衍生物具有抑制丙型肝炎病毒增殖并且毒性低的优异效果。 因此，这些化合物可用作预防和治疗丙型肝炎的药剂。

    Quinolone carboxylic acid derivatives
    9.
    发明授权
    Quinolone carboxylic acid derivatives 有权
    喹诺酮羧酸衍生物

    公开(公告)号：US06313299B1

    公开(公告)日：2001-11-06

    申请号：US09446697

    申请日：1999-12-23

    申请人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

    发明人： Sung-Joon Yoon ,  Yong-Ho Chung ,  Chi-Woo Lee ,  Yoon-Seok Oh ,  Nam-Doo Kim ,  Jae-Kyung Lim ,  Yoon-Ho Jin

    IPC分类号： C07D48710

    CPC分类号： C07D487/10

    摘要： The present invention relates to quinolonecarboxylic acid derivatives having more excellent and broad antibacterial activities than the existing quinolone-series antibiotics. More specifically, it pertains to novel quinolonecarboxylic acid derivatives represented by following formula 1, which have a derivative of 7-[8-(alkoxyimino)-2,6-diazaspiro[3.4]oct-6-yl] as a substituent, and pharmaceutically acceptable salts and isomers thereof: Wherein, A is C—H, C—F, C—Cl, C—O—CH3 or N; Y is H or amino; R1 is cyclopropyl or 2,4-difluorophenyl; R2 is C1-4 alkyl; and R3 is H or C1-4 alkyl.

    摘要翻译： 本发明涉及具有比现有的喹诺酮系列抗生素更优异和更广泛的抗菌活性的喹诺酮羧酸衍生物。 更具体地说，涉及具有7- [8-（烷氧基亚氨基）-2,6-二氮杂螺[3.4]辛-6-基]作为取代基的衍生物的下式1所示的新型喹诺酮羧酸衍生物， 其中A为CH，CF，C-Cl，CO-CH 3或N; Y是H或氨基; R1是环丙基或2,4-二氟苯基; R2是C1-4烷基; 且R 3为H或C 1-4烷基。