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公开(公告)号：US20210275472A1
公开(公告)日：2021-09-09
申请号：US17324738
申请日：2021-05-19
申请人： Pathak Holdings LLC
IPC分类号： A61K31/155 , A61K31/7036 , A61K31/496 , A61K9/00 , A61K47/34 , A61K41/00 , A61K9/16 , A61L27/50 , A61K31/727 , A61K31/337 , A61M37/00 , A61K31/573 , A61K31/37 , A61L27/38 , A61K47/32 , A61K9/06 , A61L27/22 , A61K9/50 , A61M5/32 , A61K47/02
摘要： This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
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公开(公告)号：US11045433B2
公开(公告)日：2021-06-29
申请号：US16818944
申请日：2020-03-13
申请人： Pathak Holdings LLC
IPC分类号： A61K31/155 , A61K31/7036 , A61K31/496 , A61K9/00 , A61K47/34 , A61K41/00 , A61K9/16 , A61L27/50 , A61K31/727 , A61K31/337 , A61M37/00 , A61K31/573 , A61K31/37 , A61L27/38 , A61K47/32 , A61K9/06 , A61L27/22 , A61K9/50 , A61M5/32 , A61K47/02 , A61L27/54 , A61M5/30
摘要： This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
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公开(公告)号：US20210128497A1
公开(公告)日：2021-05-06
申请号：US17141656
申请日：2021-01-05
申请人： Pathak Holdings LLC
IPC分类号： A61K31/155 , A61K9/00 , A61K31/496 , A61K31/7036 , A61K47/34 , A61M37/00 , A61K9/16 , A61K31/337 , A61K31/727 , A61L27/50 , A61L27/54 , A61K41/00 , A61K31/37 , A61K31/573
摘要： A method of forming an implant in tissue can include: providing a polymer solution having an effective amount of polymer dissolved in a biocompatible, water-soluble organic solvent; injecting a plurality of droplets of the polymer solution in the tissue; fusing the injected droplets together; dissipating the biocompatible, water-soluble organic solvent in the tissue; and precipitating the polymer from the injected polymer solution so as to form the implant.
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公开(公告)号：US10123980B2
公开(公告)日：2018-11-13
申请号：US15704792
申请日：2017-09-14
申请人： Pathak Holdings, LLC
IPC分类号： A61L31/16 , A61K31/155 , A61K9/00 , A61K31/496 , A61K31/7036 , A61K47/34 , A61M37/00 , A61K9/16 , A61K31/337 , A61K31/727 , A61L27/50 , A61L27/54 , A61K41/00 , A61K31/37 , A61K31/573 , A61M5/30
摘要： A method of forming an implant in the tissue can include: providing an injectable composition having a neat liquid carrier, wherein the neat liquid carrier is substantially liquid at room temperature and/or about body temperature; and injecting the neat liquid solution into the tissue at the rate of 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per needle per injection. The neat liquid carrier can be polymeric or non-polymeric. The neat liquid carrier can be biodegradable. The neat liquid carrier can include a viscosity-modifying agent. The injecting can form an implant with area greater than or equal to 5 mm2. The neat liquid carrier can be injected at a depth of 10 microns to 5 mm. The neat liquid solution can include a drug or other agent.
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公开(公告)号：US20180000756A1
公开(公告)日：2018-01-04
申请号：US15704792
申请日：2017-09-14
申请人： Pathak Holdings, LLC
IPC分类号： A61K31/155 , A61K9/00 , A61K9/16 , A61K31/337 , A61M37/00 , A61L27/50 , A61K41/00 , A61K31/727 , A61K31/7036 , A61K31/496 , A61K47/34 , A61L27/54 , A61M5/30
CPC分类号： A61K31/155 , A61K9/0021 , A61K9/0024 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/337 , A61K31/37 , A61K31/496 , A61K31/573 , A61K31/7036 , A61K31/727 , A61K41/0028 , A61K47/34 , A61L27/50 , A61L27/54 , A61L2400/06 , A61M5/3015 , A61M37/0015 , A61M37/0076 , A61M2037/0023 , A61M2205/3606 , A61M2205/3653 , C12Y304/21068 , C12Y304/24069
摘要： A method of forming an implant in the tissue can include: providing an injectable composition having a neat liquid carrier, wherein the neat liquid carrier is substantially liquid at room temperature and/or about body temperature; and injecting the neat liquid solution into the tissue at the rate of 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per needle per injection. The neat liquid carrier can be polymeric or non-polymeric. The neat liquid carrier can be biodegradable. The neat liquid carrier can include a viscosity-modifying agent. The injecting can form an implant with area greater than or equal to 5 mm2. The neat liquid carrier can be injected at a depth of 10 microns to 5 mm. The neat liquid solution can include a drug or other agent.
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公开(公告)号：US09789073B2
公开(公告)日：2017-10-17
申请号：US15099456
申请日：2016-04-14
申请人： Pathak Holdings, LLC
IPC分类号： A61K9/16 , A61K31/155 , A61K9/00 , A61K31/496 , A61K31/7036 , A61K47/34 , A61M37/00 , A61K31/337 , A61K31/727 , A61L27/50 , A61L27/54 , A61K41/00 , A61M5/30
CPC分类号： A61K31/155 , A61K9/0021 , A61K9/0024 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/337 , A61K31/37 , A61K31/496 , A61K31/573 , A61K31/7036 , A61K31/727 , A61K41/0028 , A61K47/34 , A61L27/50 , A61L27/54 , A61L2400/06 , A61M5/3015 , A61M37/0015 , A61M37/0076 , A61M2037/0023 , A61M2205/3606 , A61M2205/3653 , C12Y304/21068 , C12Y304/24069
摘要： This invention provide novel compositions, methods and devices for sustained drug delivery. The compositions can include a fluid carrier; a plurality of first polymeric microparticles having a bioactive agent dispersed in the fluid carrier; and a plurality of second polymeric microparticles having a visualization agent dispersed in the fluid carrier with the first microparticles. Alternative compositions can include: a fluid carrier; and a plurality of polymeric microparticles having a bioactive agent encapsulated therein and a visualization agent on a surface of the polymeric microparticles, the plurality of polymeric microparticles being dispersed in the fluid carrier. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle apparatus oscillating at 10-12000 minutes per minutes at an amount of 1.0E-03 mL to 1.0E-16 mL per injection.
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公开(公告)号：US20160243026A1
公开(公告)日：2016-08-25
申请号：US15099456
申请日：2016-04-14
申请人： Pathak Holdings, LLC
IPC分类号： A61K9/00 , A61K31/496 , A61K31/7036 , A61K9/50 , A61K38/48 , A61K47/22 , A61K47/26 , A61K47/48 , A61K31/155 , A61K9/06 , A61K47/34
CPC分类号： A61K31/155 , A61K9/0021 , A61K9/0024 , A61K9/0048 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K31/337 , A61K31/37 , A61K31/496 , A61K31/573 , A61K31/7036 , A61K31/727 , A61K41/0028 , A61K47/34 , A61L27/50 , A61L27/54 , A61L2400/06 , A61M5/3015 , A61M37/0015 , A61M37/0076 , A61M2037/0023 , A61M2205/3606 , A61M2205/3653 , C12Y304/21068 , C12Y304/24069
摘要： This invention provide novel compositions, methods and devices for sustained drug delivery. The compositions can include a fluid carrier; a plurality of first polymeric microparticles having a bioactive agent dispersed in the fluid carrier; and a plurality of second polymeric microparticles having a visualization agent dispersed in the fluid carrier with the first microparticles. Alternative compositions can include: a fluid carrier; and a plurality of polymeric microparticles having a bioactive agent encapsulated therein and a visualization agent on a surface of the polymeric microparticles, the plurality of polymeric microparticles being dispersed in the fluid carrier. The microencapsulated sustained drug delivery compositions are deposited using oscillating needle apparatus oscillating at 10-12000 minutes per minutes at an amount of 1.0E-03 mL to 1.0E-16 mL per injection.
摘要翻译： 本发明提供用于持续给药的新型组合物，方法和装置。 组合物可以包括流体载体; 多个具有分散在流体载体中的生物活性剂的第一聚合物微粒; 以及具有分散在流体载体中的可视化试剂与第一微粒的多个第二聚合物微粒。 替代组合物可以包括：流体载体; 以及多个聚合物微粒，其具有包封在其中的生物活性剂和在所述聚合物微粒的表面上的可视化剂，所述多个聚合物微粒分散在所述流体载体中。 使用以每分钟10-12000分钟振荡的振荡针装置，以每次注射1.0E-03mL至1.0E-16mL的量沉积微囊化的持续药物递送组合物。
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公开(公告)号：US20220118416A1
公开(公告)日：2022-04-21
申请号：US17503063
申请日：2021-10-15
申请人： Pathak Holdings LLC
摘要： Novel composite materials and their methods of preparation comprising a crosslinked biodegradable polymer and non-crosslinked biodegradable polymers are disclosed. The composite materials can be formed into injectable compositions comprising composite microparticles or microspheres. The non-crosslinked biodegradable polymer in the composite material is synthesized or precipitated in situ inside the particle. The non-crosslinked biodegradable polymer in the composite may be liquid, low melting solid or polymer with thermosensitive or pH sensitive gelation properties. Also disclosed are injectable compositions comprising microparticles or microspheres for controlled drug delivery wherein such particles are delivered using organic solvents. Also disclosed are methods and compositions for making two or more layered particles for medical and industrial use.
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公开(公告)号：US10918611B2
公开(公告)日：2021-02-16
申请号：US16719642
申请日：2019-12-18
申请人： Pathak Holdings LLC
IPC分类号： A61K31/155 , A61K9/00 , A61K31/496 , A61K31/7036 , A61K47/34 , A61M37/00 , A61K9/16 , A61K31/337 , A61K31/727 , A61L27/50 , A61L27/54 , A61K41/00 , A61K31/37 , A61K31/573 , A61M5/30
摘要： A method of forming an implant in a tissue can include: providing an injectable liquid composition comprising one or more precursors of a crosslinkable composition; injecting the injectable composition into the tissue at the rate of about 10-12000 injections per minute and/or at an amount of 1.0E-02 ml to 1.0E-16 ml per injection; and crosslinking the one or more precursors of the crosslinkable composition so as to form a crosslinked composition.
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公开(公告)号：US20200230081A1
公开(公告)日：2020-07-23
申请号：US16818944
申请日：2020-03-13
申请人： Pathak Holdings LLC
IPC分类号： A61K31/155 , A61M37/00 , A61K31/37 , A61K31/573 , A61K9/00 , A61K9/16 , A61K31/337 , A61K31/727 , A61L27/50 , A61K41/00 , A61K47/34 , A61K31/496 , A61K31/7036 , A61K47/02 , A61K9/50 , A61M5/32 , A61L27/22 , A61K9/06 , A61K47/32 , A61L27/38
摘要： This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
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