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公开(公告)号：US11130789B2
公开(公告)日：2021-09-28
申请号：US11658220
申请日：2005-07-22
IPC分类号： C07K14/47 , G01N33/574 , C12Q1/6886
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
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公开(公告)号：US20220064235A1
公开(公告)日：2022-03-03
申请号：US17485020
申请日：2021-09-24
IPC分类号： C07K14/47 , G01N33/574 , C12Q1/6886
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, suffering from these cancers, including bladder tumors. Genetic markers can be highly and consistently accumulated in bladder tumor tissue, other tumor tissue, and/or in urine of patients having bladder cancer. Detection of these markers can be an effective diagnostic tool to guide therapy. Detection and quantification of a plurality of bladder tumor markers using polymerase chain reaction methods can increase the sensitivity and specificity of detection of bladder cancer, provide methods for determining the stage and type of bladder cancer, and provide specific methods for treatment.
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公开(公告)号：US10179935B2
公开(公告)日：2019-01-15
申请号：US10565068
申请日：2004-07-16
IPC分类号： C12Q1/6886 , G01N33/574 , C12Q1/6837
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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公开(公告)号：US20170107583A1
公开(公告)日：2017-04-20
申请号：US15391293
申请日：2016-12-27
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
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公开(公告)号：US08822149B2
公开(公告)日：2014-09-02
申请号：US12592385
申请日：2009-11-23
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是对于黑素瘤。 具体而言，本发明涉及遗传和蛋白质标记物用于基于标记物和标记物的标记来预测癌症进展风险（例如黑素瘤）的用途。 在各个方面，本发明提供了基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以帮助癌症的预后和治疗。
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公开(公告)号：US20100136553A1
公开(公告)日：2010-06-03
申请号：US12592385
申请日：2009-11-23
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/00 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
摘要翻译： 本发明涉及预后标志物和预后特征，以及用于确定患者中癌症预后的组合物和方法，特别是对于黑素瘤。 具体而言，本发明涉及遗传和蛋白质标记物用于基于标记物和标记物的标记来预测癌症进展风险（例如黑素瘤）的用途。 在各个方面，本发明提供了基于预后癌症标志物，特别是黑素瘤预后标志物的方法，组合物，试剂盒和装置，以帮助癌症的预后和治疗。
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公开(公告)号：US20090098553A1
公开(公告)日：2009-04-16
申请号：US12221626
申请日：2008-08-05
申请人： Parry John Guilford
发明人： Parry John Guilford
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G16H50/20 , Y02A90/26
摘要： This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumour marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio, regression or classification analysis of the expression levels of at least one under-expressed TM, particularly an under-expressed bladder TM (BTM), and at least one over-expressed TM, particularly an over-expressed BTM. In various aspects, the invention telates to kits and devices for carrying out these methods.
摘要翻译： 本发明涉及基于对不足表达的肿瘤标志物（TM）和至少一种其它TM的表达水平的分析来确定受试者中癌症存在的方法。 具体地，本发明涉及通过对至少一种未表达的TM，特别是低表达的膀胱TM（BTM）的表达水平进行比例，回归或分类分析来确定癌症，特别是膀胱癌，以及 至少一个过度表达的TM，特别是过表达的BTM。 在各个方面，本发明涉及用于实施这些方法的试剂盒和装置。
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公开(公告)号：US09982305B2
公开(公告)日：2018-05-29
申请号：US13884681
申请日：2011-11-11
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , G01N33/566 , G01N33/574 , G06F19/20
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57407 , G01N2333/7155 , G06F19/20
摘要： This invention relates to the use of human neutrophil marker interleukin 8 receptor B (IL8Rb) for detection of bladder cancer, and more particularly to the use of EL8Rb for discriminating between transitional cell carcinoma of the bladder (TCC) and inflammatory conditions of the bladder.
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9.发明申请NOVEL MARKER FOR DETECTION OF BLADDER CANCER AND/OR INFLAMMATORY CONDITIONS OF THE BLADDER 有权用于检测刀片癌和/或乳头状病毒的新标志公开(公告)号：US20170002420A1
公开(公告)日：2017-01-05
申请号：US13884681
申请日：2011-11-11
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57407 , G01N2333/7155 , G06F19/20
摘要： This invention relates to the use of human neutrophil marker interleukin 8 receptor B (IL8Rb) for detection of bladder cancer, and more particularly to the use of EL8Rb for discriminating between transitional cell carcinoma of the bladder (TCC) and inflammatory conditions of the bladder.
摘要翻译： 本发明涉及人嗜中性粒细胞标志物白细胞介素8受体B（IL8Rb）用于膀胱癌的检测，更具体地说，涉及使用EL8Rb来区分膀胱移行细胞癌（TCC）和膀胱炎症状况。
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10.发明授权Medical applications of adaptive learning systems using gene expression data 有权使用基因表达数据的自适应学习系统的医学应用公开(公告)号：US07370021B2
公开(公告)日：2008-05-06
申请号：US10507737
申请日：2003-03-17
申请人： Anthony Edmund Reeve , Mathias Erwin Futschik , Michael James Sullivan , Nikola Kirilov Kasabov , Parry John Guilford
发明人： Anthony Edmund Reeve , Mathias Erwin Futschik , Michael James Sullivan , Nikola Kirilov Kasabov , Parry John Guilford
CPC分类号： G06F19/20 , G06N3/004 , G06N3/0427 , G06N3/0436
摘要： A neural network module is provided. It comprises an input layer comprising one or more input nodes configured to receive gene expression data. It also has a rule base layer comprising one or more rule nodes and an output layer comprising one or more output nodes configured to output one or more conditions. It also comprises an adaptive component configured to extract one or more rules from the rule base layer representing relationships between the gene expression data and the one or more conditions. Methods and systems using the module are disclosed as well as specific profiles utilising the system.
摘要翻译： 提供神经网络模块。 其包括输入层，其包括被配置为接收基因表达数据的一个或多个输入节点。 它还具有包括一个或多个规则节点的规则基础层和包括被配置为输出一个或多个条件的一个或多个输出节点的输出层。 它还包括被配置为从表示基因表达数据与一个或多个条件之间的关系的规则基层提取一个或多个规则的自适应组件。 公开了使用该模块的方法和系统以及利用该系统的特定简档。
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