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公开(公告)号：US09982305B2
公开(公告)日：2018-05-29
申请号：US13884681
申请日：2011-11-11
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , G01N33/566 , G01N33/574 , G06F19/20
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/566 , G01N33/57407 , G01N2333/7155 , G06F19/20
摘要： This invention relates to the use of human neutrophil marker interleukin 8 receptor B (IL8Rb) for detection of bladder cancer, and more particularly to the use of EL8Rb for discriminating between transitional cell carcinoma of the bladder (TCC) and inflammatory conditions of the bladder.
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2.发明授权Medical applications of adaptive learning systems using gene expression data 有权使用基因表达数据的自适应学习系统的医学应用公开(公告)号：US07370021B2
公开(公告)日：2008-05-06
申请号：US10507737
申请日：2003-03-17
申请人： Anthony Edmund Reeve , Mathias Erwin Futschik , Michael James Sullivan , Nikola Kirilov Kasabov , Parry John Guilford
发明人： Anthony Edmund Reeve , Mathias Erwin Futschik , Michael James Sullivan , Nikola Kirilov Kasabov , Parry John Guilford
CPC分类号： G06F19/20 , G06N3/004 , G06N3/0427 , G06N3/0436
摘要： A neural network module is provided. It comprises an input layer comprising one or more input nodes configured to receive gene expression data. It also has a rule base layer comprising one or more rule nodes and an output layer comprising one or more output nodes configured to output one or more conditions. It also comprises an adaptive component configured to extract one or more rules from the rule base layer representing relationships between the gene expression data and the one or more conditions. Methods and systems using the module are disclosed as well as specific profiles utilising the system.
摘要翻译： 提供神经网络模块。 其包括输入层，其包括被配置为接收基因表达数据的一个或多个输入节点。 它还具有包括一个或多个规则节点的规则基础层和包括被配置为输出一个或多个条件的一个或多个输出节点的输出层。 它还包括被配置为从表示基因表达数据与一个或多个条件之间的关系的规则基层提取一个或多个规则的自适应组件。 公开了使用该模块的方法和系统以及利用该系统的特定简档。
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公开(公告)号：US09702009B2
公开(公告)日：2017-07-11
申请号：US12843435
申请日：2010-07-26
申请人： Parry John Guilford
发明人： Parry John Guilford
IPC分类号： C07H21/04 , C12Q1/68 , G01N33/574 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumor marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio, regression or classification analysis of the expression levels of at least one under-expressed TM, particularly an under-expressed bladder TM (BTM), and at least one over-expressed TM, particularly an over-expressed BTM. In various aspects, the invention relates to kits and devices for carrying out these methods.
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公开(公告)号：US20110151464A1
公开(公告)日：2011-06-23
申请号：US12843435
申请日：2010-07-26
申请人： Parry John Guilford
发明人： Parry John Guilford
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57407 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumour marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio, regression or classification analysis of the expression levels of at least one under-expressed TM, particularly an under-expressed bladder TM (BTM), and at least one over-expressed TM, particularly an over-expressed BTM. In various aspects, the invention telates to kits and devices for carrying out these methods.
摘要翻译： 本发明涉及基于对不足表达的肿瘤标志物（TM）和至少一种其它TM的表达水平的分析来确定受试者中癌症存在的方法。 具体地，本发明涉及通过对至少一种未表达的TM，特别是低表达的膀胱TM（BTM）的表达水平进行比例，回归或分类分析来确定癌症，特别是膀胱癌，以及 至少一个过度表达的TM，特别是过表达的BTM。 在各个方面，本发明涉及用于实施这些方法的试剂盒和装置。
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公开(公告)号：US10266902B2
公开(公告)日：2019-04-23
申请号：US15391293
申请日：2016-12-27
IPC分类号： C12Q1/68 , G06F19/00 , C12Q1/6886 , G16H50/30
摘要： The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers. In various aspects, the invention provides methods, compositions, kits, and devices based on prognostic cancer markers, specifically melanoma prognostic markers, to aid in the prognosis and treatment of cancer.
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公开(公告)号：US09310370B2
公开(公告)日：2016-04-12
申请号：US13320392
申请日：2010-05-14
申请人： Parry John Guilford
发明人： Parry John Guilford
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N2333/47 , G01N2333/4725 , G06F19/20
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.
摘要翻译： 肿瘤的早期检测是肿瘤患者（包括胃肿瘤）存活的主要决定因素。 GTM基因家族的成员可以在胃肿瘤组织中差异表达，因此可用作检测胃癌和其他类型癌症的标志物。 本发明提供用于检测肿瘤的新型GTM，包括胃肿瘤，特别是人酶原颗粒蛋白16（ZG16）。 GTM可以分离使用或与其他已知的GTM一起使用，以提供用于检测肿瘤（包括胃肿瘤）的新颖特征。
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公开(公告)号：US20120135881A1
公开(公告)日：2012-05-31
申请号：US13320392
申请日：2010-05-14
申请人： Parry John Guilford
发明人： Parry John Guilford
IPC分类号： C40B30/04 , C12M1/34 , G01N33/566 , G01N33/577 , C12Q1/68 , G01N33/573
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N2333/47 , G01N2333/4725 , G06F19/20
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be differentially expressed in gastric tumor tissue, and thus can be used as markers for the detection of gastric and other types of cancer. The present invention provides for novel GTMs for the detection of tumors, including gastric tumors, and in particular human zymogen granule protein 16 (ZG16). The GTMs can be used in isolation or together with other known GTMs to provide for novel signatures to be used in the detection of tumors, including gastric tumors.
摘要翻译： 肿瘤的早期检测是肿瘤患者（包括胃肿瘤）存活的主要决定因素。 GTM基因家族的成员可以在胃肿瘤组织中差异表达，因此可用作检测胃癌和其他类型癌症的标志物。 本发明提供用于检测肿瘤的新型GTM，包括胃肿瘤，特别是人酶原颗粒蛋白16（ZG16）。 GTM可以分离使用或与其他已知的GTM一起使用，以提供用于检测肿瘤（包括胃肿瘤）的新颖特征。
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公开(公告)号：US20100273148A1
公开(公告)日：2010-10-28
申请号：US11658220
申请日：2005-07-22
IPC分类号： C12Q1/68 , G01N33/68 , C12Q1/26 , C40B30/00 , G01N33/566 , G01N33/573 , C12M1/00
CPC分类号： C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N2800/52
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
摘要翻译： 肿瘤的早期检测是患有肿瘤的患者（包括膀胱肿瘤）的主要决定因素。 BTM或UBTM家族的成员可以高度一致地积聚在膀胱肿瘤组织和其他肿瘤组织中，和/或可以积聚在患者的尿液中，因此是膀胱癌和其他类型癌症的标志物。 在某些实施方案中，BTM或UBTM可以积聚在尿液中，并且UBTM家族成员的检测可以是有效的诊断方法。 在一些实施方案中，定量PCR方法优于微阵列方法。 在其他实施方案中，多个BTM或UBTM的检测和定量可以增加膀胱癌检测的灵敏度和特异性，因此提供了确定膀胱癌的阶段和类型的方法。 试剂盒提供方便实施本发明方法的方便。
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公开(公告)号：US11130789B2
公开(公告)日：2021-09-28
申请号：US11658220
申请日：2005-07-22
IPC分类号： C07K14/47 , G01N33/574 , C12Q1/6886
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.
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公开(公告)号：US10179935B2
公开(公告)日：2019-01-15
申请号：US10565068
申请日：2004-07-16
IPC分类号： C12Q1/6886 , G01N33/574 , C12Q1/6837
摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including gastric tumors. Members of the GTM gene family can be over-expressed in gastric tumor tissue and other tumor tissue, and thus can be used as markers for gastric and other types of cancer. GTM proteins can be released from cancer cells, and can reach sufficiently high concentrations in the serum and/or other fluids to permit their detection. Thus, methods and test kits for detection and quantification of GTM can provide a valuable tool for diagnosis of gastric cancer.
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