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    Spheron component peptides and pharmaceutical compositions
    2.
    发明授权
    Spheron component peptides and pharmaceutical compositions 有权
    菠菜组分肽和药物组合物

    公开(公告)号：US07514407B2

    公开(公告)日：2009-04-07

    申请号：US10444070

    申请日：2003-05-23

    Applicant: Paul Averback

    Inventor： Paul Averback

    IPC: A61K38/10 ,  A61K38/17 ,  C07K7/02 ,  C07K7/08 ,  C07K14/47

    CPC classification number: C07K7/08 ,  A01K2217/05 ,  C07K7/06 ,  C07K14/4702 ,  C07K14/4711

    Abstract: The present invention relates to racemized proteins and racemized protein components of spherons that are useful for identifying compounds capable of preventing and/or ameliorating symptoms of Alzheimer's Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to the compounds identified by the methods, and methods of treating and/or ameliorating symptoms of Alzheimer's Disease and/or dementia associated with cerebral amyloidosis. The invention also relates to methods of making an Alzheimer's Disease or dementia associated with cerebral amyloidosis animal model or test animal, the animal model produced therefrom, and to a method of using the animal model to screen for effective therapies.

    Abstract translation: 本发明涉及可用于鉴定能够预防和/或改善阿尔茨海默氏病和/或与脑淀粉样变性相关的痴呆症状的化合物的球面的外消旋化蛋白质和外消旋化蛋白质组分。 本发明还涉及通过所述方法鉴定的化合物，以及治疗和/或改善与脑淀粉样变性相关的阿尔茨海默病和/或痴呆症状的方法。 本发明还涉及制备与脑淀粉样变性动物模型或测试动物相关的阿尔茨海默病或痴呆的方法，由其产生的动物模型，以及使用动物模型筛选有效治疗的方法。

    Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis or growth of DMS
    4.
    发明授权
    Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis or growth of DMS 有权
    通过阻碍DMS的发生或生长阻止淀粉样蛋白形成的药物活性剂

    公开(公告)号：US07270818B2

    公开(公告)日：2007-09-18

    申请号：US10186681

    申请日：2002-07-02

    Applicant: Paul Averback

    Inventor： Paul Averback

    IPC: A61K39/395

    CPC classification number: C07K14/4711

    Abstract: Methods of treating and/or prophylaxis Alzheimer's disease by preventing the formation of cerebral amyloid due to the growth and disruption of dense microspheres (DMS) are disclosed utilizing medicaments that are effective in preventing or inhibiting the growth and disruption of DMS.

    Abstract translation: 使用有效预防或抑制DMS的生长和破坏的药物，公开了通过预防由于致密微球（DMS）的生长和破坏而形成脑淀粉样蛋白来治疗和/或预防阿尔茨海默氏病的方法。

    Pharmaceutically active agents that impede amyloid formation in vivo
    6.
    发明授权
    Pharmaceutically active agents that impede amyloid formation in vivo 失效
    妨碍体内淀粉样蛋白形成的药物活性剂

    公开(公告)号：US06727278B1

    公开(公告)日：2004-04-27

    申请号：US08482768

    申请日：1995-06-07

    Applicant: Paul Averback

    Inventor： Paul Averback

    IPC: A61K31505

    CPC classification number: G01N33/6896 ,  A61K31/35 ,  A61K31/40 ,  A61K31/42 ,  A61K31/505 ,  A61K31/55 ,  A61K31/63 ,  A61K31/655 ,  A61K31/70 ,  C07H17/08 ,  C07H19/06 ,  G01N33/5088 ,  G01N2333/4709 ,  G01N2500/00

    Abstract: Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10−5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.

    Abstract translation: 密集的微球可以从哺乳动物脑组织中提取和纯化到基本上均匀性，并用于筛选治疗以阻止与阿尔茨海默病和其他形式的脑淀粉样变性相关的淀粉样蛋白原纤维形成的潜在有效性。 在组织浓度为10 -5 M以下的化合物抑制用致密微球注射脑内的试验动物中的淀粉样蛋白形成特别适用于抑制治疗脑淀粉样变性。

    Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells
    8.
    发明授权
    Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells 有权
    有效治疗肿瘤和其他需要去除或破坏细胞的条件的肽

    公开(公告)号：US08067378B2

    公开(公告)日：2011-11-29

    申请号：US11680119

    申请日：2007-02-28

    Applicant: Paul Averback ,  Jack Gemmell

    Inventor： Paul Averback ,  Jack Gemmell

    IPC: A61K38/08 ,  A61K38/16

    CPC classification number: C07K19/00 ,  A61K38/00 ,  C07K7/08

    Abstract: The embodiments include methods of treating conditions requiring removal or destruction of cellular elements, such as benign or malignant tumors in humans, using compounds based on small peptides. The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier.

    Abstract translation: 实施方案包括使用基于小肽的化合物治疗需要去除或破坏细胞元件（例如人类的良性或恶性肿瘤）的病症的方法。 该方法包括但不限于单独或与载体缀合的肌内，口服，静脉内，鞘内，肿瘤内，鼻内，局部，经皮等方式施用化合物。

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