摘要:
The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation, comprising detecting the presence or absence in the genome of the dog of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene that is indicative of susceptibility to liver copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a). The invention also provides a method of determining the likelihood that a dog is protected from liver copper accumulation comprising detecting the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO: 142) and (b) one or more polymorphisms in linkage disequilibrium with (a).
摘要翻译:本发明提供了确定狗对肝铜积累的敏感性的方法,其包括检测狗基因组中存在或不存在(a)GOLGA5,ATP7a或UBL5基因的多态性,其指示易感性 肝铜积聚和/或(b)与所述多态性(a)的连锁不平衡中的多态性。 本发明还提供了确定狗被保护免受肝铜积聚的可能性的方法,其包括检测狗的基因组中存在或不存在选自(a)SNP ATP7a_Reg3_F_6(SEQ ID NO:142)的一种或多种多态性 和(b)与(a)的连锁不平衡中的一个或多个多态性。
摘要:
The invention provides a method of predicting the size of a dog that will be attained in adulthood, comprising typing the nucleotide(s) present for a single nucleotide polymorphic (SNP) marker present in the genome of the dog at a position equivalent to position 201 in one or more of the sequences identified in Table 1, and/or at one or more positions which are in linkage disequilibrium with any one of these positions, and thereby predicting the size of the dog that will be attained in adulthood.
摘要:
The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).
摘要翻译:本发明提供了一种测试狗的方法,以确定狗被保护免受肝铜积聚的可能性,包括在样本中检测狗的基因组中存在或不存在选自(a)SNP的一种或多种多态性 ATP7a_Reg3_F_6(SEQ ID NO:142)和(b)与(a)的连锁不平衡中的一个或多个多态性。
摘要:
The present invention provides a method of testing a dog to determine the likelihood that the dog is protected from liver copper accumulation, comprising detecting in a sample the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO:142) and (b) one or more polymorphisms in linkage disequilibrium with (a).
摘要翻译:本发明提供了一种测试狗的方法,以确定狗被保护免受肝铜积聚的可能性,包括在样本中检测狗的基因组中存在或不存在选自(a)SNP的一种或多种多态性 ATP7a_Reg3_F_6(SEQ ID NO:142)和(b)与(a)的连锁不平衡中的一个或多个多态性。
摘要:
The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation comprising detecting the presence or absence of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene of the dog that is indicative of susceptibility to copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a), and thereby determining the susceptibility of the dog to liver copper accumulation. The invention also provides a foodstuff comprising copper at a concentration of less than 21 mg/kg dry matter for use in preventing a disease attributable to liver copper accumulation in a dog having genetic inheritance of the Labrador Retriever breed.
摘要:
A method of determining susceptibility to periodontitis in a Shih Tzu dog, Yorkshire Terrier dog or a dog of a breed that is genetically related to the Shih Tzu or Yorkshire Terrier breed, comprises: a) typing the nucleotide present in the genome of the dog at or at a position equivalent to each of the following: position 201 of SEQ ID NO: 2 (SNP_02), or a position that is in linkage disequilibrium with this position,—position 201 of SEQ ID NO: 4 (SNP_04), or a position that is in linkage disequilibrium with this position, and position 201 of SEQ ID NO: 9 (SNPJ39), or a position that is in linkage disequilibrium with this position, and b) thereby determining whether the dog is susceptible to periodontitis.
摘要翻译:在Shih Tzu狗,约克夏犬或与Shih Tzu或Yorkshire Terrier品种遗传相关的品种的狗中确定牙周炎敏感性的方法包括:a)将存在于狗的基因组中的核苷酸分型 或与下列各项相当的位置:SEQ ID NO:2的位置201(SNP_02)或与该位置连锁不平衡的位置,SEQ ID NO:4(SNP_04)的位置201或 与该位置连锁不平衡的位置,以及SEQ ID NO:9(SNPJ39)的位置201,或与该位置连锁不平衡的位置,以及b)由此确定狗是否易患牙周病。