GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS AND LOW COPPER PET DIET
    1.
    发明申请
    GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS AND LOW COPPER PET DIET 审中-公开
    在狗和低铜饮料中肝脏铜累积的遗传测试

    公开(公告)号:US20120208182A1

    公开(公告)日:2012-08-16

    申请号:US13122070

    申请日:2009-10-05

    摘要: The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation, comprising detecting the presence or absence in the genome of the dog of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene that is indicative of susceptibility to liver copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a). The invention also provides a method of determining the likelihood that a dog is protected from liver copper accumulation comprising detecting the presence or absence in the genome of the dog of one or more polymorphisms selected from (a) SNP ATP7a_Reg3_F_6 (SEQ ID NO: 142) and (b) one or more polymorphisms in linkage disequilibrium with (a).

    摘要翻译: 本发明提供了确定狗对肝铜积累的敏感性的方法,其包括检测狗基因组中存在或不存在(a)GOLGA5,ATP7a或UBL5基因的多态性,其指示易感性 肝铜积聚和/或(b)与所述多态性(a)的连锁不平衡中的多态性。 本发明还提供了确定狗被保护免受肝铜积聚的可能性的方法,其包括检测狗的基因组中存在或不存在选自(a)SNP ATP7a_Reg3_F_6(SEQ ID NO:142)的一种或多种多态性 和(b)与(a)的连锁不平衡中的一个或多个多态性。

    PREDICTIVE TEST FOR ADULT DOG BODY SIZE
    2.
    发明申请
    PREDICTIVE TEST FOR ADULT DOG BODY SIZE 审中-公开
    成年犬身体尺寸的预测性测试

    公开(公告)号:US20110021364A1

    公开(公告)日:2011-01-27

    申请号:US12741961

    申请日:2008-11-07

    摘要: The invention provides a method of predicting the size of a dog that will be attained in adulthood, comprising typing the nucleotide(s) present for a single nucleotide polymorphic (SNP) marker present in the genome of the dog at a position equivalent to position 201 in one or more of the sequences identified in Table 1, and/or at one or more positions which are in linkage disequilibrium with any one of these positions, and thereby predicting the size of the dog that will be attained in adulthood.

    摘要翻译: 本发明提供了一种预测在成年期将达到的狗的大小的方法,其包括将存在于狗基因组中的单核苷酸多态性(SNP)标记的核苷酸分类在等同于位置201的位置 在表1中鉴定的一个或多个序列中,和/或与这些位置中的任何一个处于连锁不平衡的一个或多个位置,从而预测在成年期将达到的狗的大小。

    GENETIC TEST AND PET DIET
    5.
    发明申请
    GENETIC TEST AND PET DIET 审中-公开
    遗传测试和PET饮料

    公开(公告)号:US20100278938A1

    公开(公告)日:2010-11-04

    申请号:US12680853

    申请日:2008-10-03

    IPC分类号: A61K33/34 A61P1/16

    摘要: The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation comprising detecting the presence or absence of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene of the dog that is indicative of susceptibility to copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a), and thereby determining the susceptibility of the dog to liver copper accumulation. The invention also provides a foodstuff comprising copper at a concentration of less than 21 mg/kg dry matter for use in preventing a disease attributable to liver copper accumulation in a dog having genetic inheritance of the Labrador Retriever breed.

    摘要翻译: 本发明提供了一种确定狗对肝铜沉积的易感性的方法,其包括检测狗的GOLGA5,ATP7a或UBL5基因中是否存在(a)多态性,其表示对铜积累的敏感性和/ 或(b)与所述多态性(a)的连锁不平衡中的多态性,从而确定狗对肝铜积聚的敏感性。 本发明还提供了一种含有浓度小于21mg / kg干物质的铜的食品,用于防止属于拉布拉多猎犬品种遗传遗传的狗的肝铜积聚的疾病。

    Dog Periodontitis
    6.
    发明申请
    Dog Periodontitis 审中-公开
    狗牙周炎

    公开(公告)号:US20080226766A1

    公开(公告)日:2008-09-18

    申请号:US12067072

    申请日:2006-09-18

    摘要: A method of determining susceptibility to periodontitis in a Shih Tzu dog, Yorkshire Terrier dog or a dog of a breed that is genetically related to the Shih Tzu or Yorkshire Terrier breed, comprises: a) typing the nucleotide present in the genome of the dog at or at a position equivalent to each of the following: position 201 of SEQ ID NO: 2 (SNP_02), or a position that is in linkage disequilibrium with this position,—position 201 of SEQ ID NO: 4 (SNP_04), or a position that is in linkage disequilibrium with this position, and position 201 of SEQ ID NO: 9 (SNPJ39), or a position that is in linkage disequilibrium with this position, and b) thereby determining whether the dog is susceptible to periodontitis.

    摘要翻译: 在Shih Tzu狗,约克夏犬或与Shih Tzu或Yorkshire Terrier品种遗传相关的品种的狗中确定牙周炎敏感性的方法包括:a)将存在于狗的基因组中的核苷酸分型 或与下列各项相当的位置:SEQ ID NO:2的位置201(SNP_02)或与该位置连锁不平衡的位置,SEQ ID NO:4(SNP_04)的位置201或 与该位置连锁不平衡的位置,以及SEQ ID NO:9(SNPJ39)的位置201,或与该位置连锁不平衡的位置,以及b)由此确定狗是否易患牙周病。